Method for preparing chitosan in situ gel agent

Abstract

The invention discloses a preparation method of chitosan in situ gel preparation, which belongs to the medicine technical field. The invention comprises the steps as follows: first, dissolving chitosan into water solution and / or water solution with cosolvent; second, adding medicine into the chitosan solution and stirring sufficiently; third, adding strong base-weak acid salt into the chitosan solution slowly in CO2 atmosphere and under the stirring condition, and keeping stirring; fourth, distributing the evenly mixed chitosan collosol into sterile bottles with stoppers for sealing or filling chitosan collosol into an atomizing device under the protection by CO2 and then obtaining the chitosan in situ gel preparation. The invention not only avoids using organic solvent in the cause of preparation production but also simplifies the preparation production flow and widens the preparation application ways.

Description

technical field

[0001] The invention relates to a preparation method in the technical field of medicine, in particular to a preparation method of chitosan in-situ gel medicament. Background technique

[0002] Chitosan (Chitosan) is chitin off C 2 Acetyl products, also known as chitosan, deacetylated chitin, soluble chitin, polyglucosamine, etc. Chitosan contains a large number of free amino groups in its structure, which can bind acid molecules. It is the only basic polysaccharide among natural polysaccharides, and it is also one of the few natural products with positive charges. Because of this unique physical and chemical properties, as well as its low price and good biocompatibility, it can be widely used in the pharmaceutical industry. At present, chitosan-based drug delivery mainly includes chitosan microspheres and chitosan sustained-release drug films.

[0003] After searching the prior art documents, it is found that the Chinese patent announcement number is CN101...