Method for preparing chitosan in situ gel agent
An in-situ gel and chitosan sol technology, which is applied in the field of medicine, can solve the problems of thermally unstable drug preparation, poor film flexibility, and difficult product quality assurance, so as to solve the uncontrollable quality of preparations and expand delivery methods , The effect of reducing production costs
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0021] 1. Dissolving 50 mg of chitosan with a degree of deacetylation of 60% and a viscosity of 50 cP in 5 ml of dilute hydrochloric acid aqueous solution of pH 4;
[0022] 2. Add antibacterial drugs with a theoretical drug load of 1% to the chitosan solution and stir thoroughly;
[0023] 3.CO 2 Under the atmosphere, under stirring condition at 4°C, add 10ml of 0.25M aqueous sodium bicarbonate solution dropwise into the acid solution of chitosan, and continue to stir for 2min;
[0024] 4. In CO 2 Under protection, the homogeneously mixed chitosan sol is divided into vials with stoppers and sealed to obtain the chitosan in situ gel administration preparation.
[0025] Implementation effect: The chitosan in situ gel drug preparation prepared by the present invention does not contain any organic solvents and harmful components to the human body. When in use, the chitosan in situ gel is applied to the skin surface to form a tight layer. A film that adheres to the surface of the...
Embodiment 2
[0027] 1. Dissolve 150 mg of chitosan with a degree of deacetylation of 80% and a viscosity of 200 cP in 15 ml of dilute nitric acid aqueous solution at pH 2 containing acetone;
[0028] 2. Add conventional antifungal drugs with a theoretical drug loading of 20% to the chitosan solution, and fully stir;
[0029] 3.CO 2 Under the atmosphere, under 10°C and stirring conditions, slowly add 20ml of 0.35M sodium carbonate aqueous solution into the chitosan acid solution, and continue stirring for 5 minutes;
[0030] 4. In CO 2 Under protection, the homogeneously mixed chitosan sol is divided into polyvinyl chloride plastic vials to obtain the chitosan in situ gel administration preparation.
[0031] Implementation effect: the chitosan in situ gel preparation prepared by the present invention does not contain any organic solvents and harmful components to the human body. When in use, the chitosan in situ gel is dripped into the nasal cavity to form a layer of tight adhesion The d...
Embodiment 3
[0033] 1. Dissolve 600 mg of chitosan with a degree of deacetylation of 95% and a viscosity of 500 cP in an aqueous solution of dilute hydrochloric acid / dilute nitric acid of pH 0.5 in 30 ml;
[0034] 2. Add conventional antineoplastic drugs with a theoretical drug load of 40% to the acid solution of chitosan, and fully stir;
[0035] 3.CO 2 Under the atmosphere, under stirring conditions at 2°C, slowly add 30ml of 0.3M potassium bicarbonate aqueous solution into the chitosan acid solution, and continue stirring for 10 minutes;
[0036] 4. In CO 2 Under protection, the homogeneously mixed chitosan sol is divided into glass vials with stoppers to obtain the chitosan in situ gel administration preparation.
[0037] Implementation effect: the chitosan in situ gel administration preparation prepared by the present invention does not contain any organic solvents and harmful components to the human body. When in use, the chitosan in situ gel is injected into the tumor resection si...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com