32results about How to "Avoid gastrointestinal irritation" patented technology

The present invention relates to the field of medicine technology and is one externally applied form of Cetirizine hydrochloride gel as one histamine resisting medicine and its preparation. The present invention prepares the gel with Cetirizine hydrochloride as main medicine component and different supplementary material, and the gel is administrated via skin or mucous membrane. The present invention can avoid liver reaction and stimulation to gstrointestinal tract of the medicine, reduce medicine concentration in blood, reduce central nerve suppressing effect, raise the medicine concentration in local affected part, decrease the administration times and raise patient's compatibility.

The invention relates to a traditional Chinese medicine gel for treating arthritis and preparation method thereof, belonging to medical field. The gel is composed of raw sihcuan axonite root extract and pharmaceutical adjuvant by the following weight ratio: raw sihcuan axonite root extract 1.5%, camphor 0.1%, musk 0.04%, high molecular matrix material 0.1-5%, humectant 5-15%, preservatives 0-0.5%, solvent 50-80%.

The invention, relating to the technical field of medicine, provides a Chinese-medicinal compound lotion for treating dermatitis eczema and a preparation method thereof. The component proportion of the lotion is: 50-70g of sophora flavescens, 40-60g of common cnidium fruit, 20-40g of phellodendron, 25-35g of Chinese angelica, 15-25g of Ligusticum wallichii, 15-30g of rheum officinale, 3-6g of borneol, and 0.1wt% of antiseptic ethylparaben. The preparation method comprises the following steps: 1) preparing an extract of sophora flavescens, common cnidium fruit and phellodendron; 2) preparing an extract of Chinese angelica, Ligusticum wallichii and rheum officinale; 3) mixing the extracts obtained by step 1) and 2), adding borneol according to the proportion and 0.1wt% of antiseptic ethylparaben, adding water until the amount of the mixture reaches to 1000ml for dilution, and sub-packaging. The lotion can avoid the irritation on gastrointestinal tracts by oral administration, reduce the blood concentration of body and reduce side effects through the transdermal drug delivery. The preparation method is simple, and the lotion is easy to operate and improves the compliance of medicine. The invention provides a novel medicinal preparation for treating dermatitis eczema.

The invention discloses a compound aloetic bacteriostatic traditional Chinese medicine film and a preparation method thereof. The compound aloetic bacteriostatic traditional Chinese medicine film comprises the following components in parts by weight: 15-25 parts of chitosan, 5-100 parts of traditional Chinese medicine effective constituents and 1-2 parts of glycerin, wherein the traditional Chinese medicine effective constituents include 28-55 parts of aloe extracting solutions, 20-40 parts of bletilla striata extracting solutions and 1-15 parts of radix ampelopsis extracting solutions. The compound aloetic bacteriostatic traditional Chinese medicine film has bacteriostatic effects of different degrees on staphylococcus aureus, staphylococcus epidermidis and colon bacillus, is prepared from natural pure traditional Chinese medicines, has the advantages of softness, transparency, safety, high hydrophilicity and ventilation property, no irritation, and the like, not only can resist bacteria and diminish inflammation, but also can eliminate swelling and promote granulation, thereby preventing the weakness of drug fastness caused by using antibiotics for a long time and being beneficial to healing a wound surface; in addition, the discloses a compound aloetic bacteriostatic traditional Chinese medicine film used as an adjuvant therapy medicine for ulcer, bedsore, skin or mucosa infection and minor operation incision infection on clinic has very well application prospect.

The invention belongs to the preparation field of western medicines and particularly relates to a high-efficiency and quick-acting phentolamine external preparation which takes natural plant naphtha and the extraction elaboration product thereof as a transdermal sorbefacient and a preparation method thereof. The invention selects the transdermal sorbefacient of natural volatile oils, takes phentolamine as the main active substance which plays a role in treatment in the preparation and is added with the accessories necessary in pharmacy, so as to prepare the phentolamine external transdermal preparation. Proved by experimentation on animals, the preparation can largely reduce the medication dosage and lower the systemic side effect and use cost when simultaneously maintaining the effectiveness of drugs. Compared with the prior art, the preparation can significantly improve the transdermal drug absorption amount of phentolamine, and shorten latent period of onset, has good medication safety and can offer patients more satisfactory curative effect.

The invention provides a Chinese medicine composition to achieve the purpose of treating senile vaginitis through dispelling wind, arresting itching, removing dampness, and destroying parasites. In order to achieve the purpose, the following technical scheme is adopted: active components contained in the Chinese medicine composition are prepared by the following raw materials in parts by weight: 10-20 parts of radix stemonae, 10-20 parts of semen armeniacae amarae, 10-20 parts of chinaberry seeds, 10-20 parts of lindley eupatorium, 10-20 parts of patrinia heterophylla, 10-20 parts of oroxylum indicum, 10-20 parts of polygonum cuspidatum, 1-3 parts of borneol, 1-3 parts of carbomer, 50-100 parts of glycerol, 1-3 parts of triethanolamine and 425-475 parts of distilled water; and the raw materials are prepared into gel by adopting a corresponding preparation method. The Chinese medicine composition has the functions of dispelling wind, arresting itching, removing dampness, and destroying parasites, and can be used for treating the senile vaginitis.

The invention relates to medicinal liquor and particularly relates to externally applied medicinal liquor for treating lumbar and leg ache. The externally applied medicinal liquor for treating lumbar and leg ache is prepared by soaking asarum, liquidambar formosana hance, angelica sinensis, frankincense, radix aconiti, caulis spatholobi, fructus aurantii, rheum officinale, peach kernels, radix clematidis, flos carthami, myrrh, cassia twig, dandelion, salviae miltiorrhizae, hematoxylon, scandent schefflera stems and leaves and borneol in wine, wherein asarum contains volatile oil which has the antipyretic and antinociceptive effects; liquidambar formosana hance contains sanchinoside which has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain and dredging channels and stopping bleeding; angelica sinensis, frankincense, radix aconiti, caulis spatholobi, salviae miltiorrhizae and the like have the functions of promoting circulation of blood, invigorating the circulation of blood and relieving pains; borneol is led to the apertures to assist the medicines to directly reach the diseased regions.

The present invention belongs to the field of Chinese medicine technology, and is especially one kind of compounding Chinese gel preparation for treating osteoarthropathy and its preparation process. The Chinese gel preparation consists of raw aconite root extractive, datura flower extractive, camphor, musk, polymer as matrix, solvent, humectant, preservative and other supplementary material. Compared with available technology, the Chinese gel preparation for transdermal administration of the present invention has no irritation to gastrointestinal tract, lowered body blood medicine concentration, reduced toxic side effect, prolonged acting period, raised patient compliance to the medicine, easy use and low cost.

The present invention relates to tromethamine gel with tromethamine as effective non-steroid medicine component for relieving pain and diminishing inflammation caused by surgical operation, fracture, strain, cancer, etc. through skin, mucous membrane or other local application, and aims at raising the long term stability, raising the bioavailability of the medicine component, reducing stimulation and raising the curative effect and medicine applying safety. The final medicine composition contains tromethamine 0.5-2.0 wt%, gel matrix 0.1-1.0 wt%, transdermal absorbent 0.2-2.0 wt%, humectant 0.2-2.0 wt%, and pH buffering agent 0.3-1.5 wt%. It is preparation through convenient gel preparing process.

The present invention relates to one kind of release controlling microcapsule preparation for preventing abdominal cavity carcinomatosis and its abdominal cavity infusing application technology. The release controlling microcapsule preparation is infused into abdominal cavity after cancer tissue incising operation and the medicine is released timely to prevent carcinomatosis and inhibit the growth of cancer cells. Technologically, the present invention includes three key aspects: preparing release controlling microcapsule, selecting proper solvent and abdominal cavity infusion technology. By means of the technology of combining release controlling microcapsule and abdominal cavity infusion, the present invention has high medicine bioavailability.

The invention discloses an eczema care solution which is applied to the treatment of eczema. The eczema care solution is characterized by being prepared from a plurality of traditional Chinese medicines, and contains the following raw pharmaceutical materials in parts by weight: 10-20 parts of honeysuckle stem, 10-20 parts of dahurian angelica root, 15-20 parts of cortex dictamni, 10-15 parts of cocklebur fruit, 1-3 parts of chaulmoogra, 10-15 parts of five-leaf akebia fruit, 10-20 parts of red peony root, 6-12 parts of codonopsis lanceolata, 6-12 parts of polygonum orientale fruit, 6-12 parts of chinaroot greenbrier, 10-15 parts of buchnera cruciata and 6-12 parts of verbena. Proved by clinical trials, the eczema care solution has the characteristics of good treatment effect and relatively high safety in the treatment of eczema, so that the eczema care solution is worthy of clinical application and popularization.

The invention discloses a periodic traditional Chinese medicine patch for treating gynecological diseases. The periodic traditional Chinese medicine patch comprises the following raw materials in parts by weight of 6-18 parts of fructus ligustri lucidi, 9-18 parts of semen cuscutae, 6-15 parts of rhizoma polygonati, 6-18 parts of herba epimedii and 2-12 parts of ramulus cinnamomi or cortex cinnamomi. The preparation method of the periodic traditional Chinese medicine patch for treating the gynecological diseases comprises the following steps of (1) weighing the raw materials in parts by weightof the periodic traditional Chinese medicine patch for treating the gynecological diseases; (2) mixing the raw materials except ginger juice, and then performing grinding and sieving to obtain mixedmedicine powder; and (3) mixing the mixed medicine powder with the ginger juice, and performing pressing to form a medicine cake so as to obtain the traditional Chinese medicine patch. The traditionalChinese medicine patch disclosed by the invention can be applied to different symptoms before and after ovulation, can avoid stimulation and toxic and side effects of oral medicines on the gastric tract, has dual treatment effects of percutaneous absorption of medicines and stimulation of meridian points, and is remarkable in curative effect, low in side effect and convenient to use.

The invention relates to a novel gynecological Qianjin zedoary turmeric oil suppository. The preparation method comprises the following steps: (1) taking raw materials: radix flemingiae macrophyllae, radix rosae laevigatae, caulis mahoniae, caulis spatholobi, radix zanthoxylum echinocarpum, herba andrographis, radix codonopsis, radix angelicae sinensis and zedoary turmeric oil; (2) preparing extractives; (3) heating and melting polyethylene glycol 6000 and poloxamer 188 in water bath, adding tween-80, the zedoary turmeric oil and extractives, stirring evenly and fully, keeping warm, pouring into a suppository mold coated with liquid paraffin on the surface, and obtaining the Qianjin zedoary turmeric oil suppository after cooling. According to the novel gynecological Qianjin zedoary turmeric oil suppository, drug parts of gynecological Qianjin capsules are integrated with the zedoary turmeric oil to prepare the suppository, plugging the suppository into a vaginal can treat vaginitis and cervicitis; plugging the suppository into a rectum can treat dysmenorrhea, amenorrhea, soreness of waist, annexitis, endometritis, chronic pelvic inflammatory disease and the like, and the suppository can also be used in a menstrual period. Rectal blood circulation is very rich, the drug does not pass through an upper gastrointestinal tract after the suppository is used, gastrointestinal irritation is avoided, the drug can be quickly absorbed to reach a pelvic cavity and plays a therapeutic effect, and obvious toxic and side effects are avoided.

The invention discloses a compound aloetic bacteriostatic traditional Chinese medicine film and a preparation method thereof. The compound aloetic bacteriostatic traditional Chinese medicine film comprises the following components in parts by weight: 15-25 parts of chitosan, 5-100 parts of traditional Chinese medicine effective constituents and 1-2 parts of glycerin, wherein the traditional Chinese medicine effective constituents include 28-55 parts of aloe extracting solutions, 20-40 parts of bletilla striata extracting solutions and 1-15 parts of radix ampelopsis extracting solutions. The compound aloetic bacteriostatic traditional Chinese medicine film has bacteriostatic effects of different degrees on staphylococcus aureus, staphylococcus epidermidis and colon bacillus, is prepared from natural pure traditional Chinese medicines, has the advantages of softness, transparency, safety, high hydrophilicity and ventilation property, no irritation, and the like, not only can resist bacteria and diminish inflammation, but also can eliminate swelling and promote granulation, thereby preventing the weakness of drug fastness caused by using antibiotics for a long time and being beneficial to healing a wound surface; in addition, the discloses a compound aloetic bacteriostatic traditional Chinese medicine film used as an adjuvant therapy medicine for ulcer, bedsore, skin or mucosa infection and minor operation incision infection on clinic has very well application prospect.

The invention relates to medicinal liquor and especially relates to and discloses externally-used medicinal liquor for treating ischemic heart disease. The medicinal liquor is prepared by soaking medicines including monkshood, cinnamon, achyranthes bidentata, gentiana macrophylla, mulberry twigs, aconitum gymnandrum, angelica pubescens, red peony roots, uncaria tomentosa, scorpions, bombyx batryticatus, earthworm, fresh ginger and radix glycyrrhizae in liquor. According to traditional Chinese medicine theories, the medicinal liquor is prepared through a combination formula according to relationships among monarch drugs, minister drugs, assistant drugs and guide drugs on the basis of functions of the medicines so that the effects of the medicines can be achieved in a cooperation manner. The medicinal liquor has main effects of freeing yang and opening paralysis and freeing collaterals and relieving pains and is mainly used for treating acute myocardial infarction, unstable angina pectoris and the like.

The invention discloses a traditional Chinese medicine plaster for treating gynecological blood stasis syndrome, which is prepared by the following method: grinding three-lens, curcuma, asarum, frankincense, myrrh, and paojiang into a medicinal powder, and making a thick paste with ginger juice. Medicine cake. The traditional Chinese medicine application of the present invention has remarkable clinical curative effect in treating gynecological blood stasis syndrome, has a high total effective rate, can effectively improve the symptoms of abdominal pain or pelvic pain during menstruation, and can effectively improve aversion to cold and warmth, mental fatigue, lack of energy, lazy speech, and spontaneous sweating , urine leakage or incontinence, back pain, shin soreness, soft knees, or heel pain are symptoms of gynecological blood stasis syndrome caused by deficiency and cold. The treatment by application can avoid gastrointestinal stimulation and toxic side effects of oral medicines, has dual therapeutic effects of percutaneous absorption of medicines and stimulation of meridians and acupoints, has remarkable curative effect, low side effects, and is convenient to use.

The invention discloses a pharmaceutical composition as well as a preparation method and application thereof. The pharmaceutical composition comprises bepotastine besilate, a tackifier, a tension agent, a preservative and a pH regulator, wherein the granularity D90 of the bepotastine besilate is 2-10 [mu]m. The preparation method of the pharmaceutical composition comprises the following steps of (1) pre-treating the bepotastine besilate; and (2) preparing the pharmaceutical composition. The preparation method is simple and easy to implement, and the prepared pharmaceutical composition enters the nasal cavity through a portable spraying device, is convenient to administrate, takes effect quickly, can release drugs slowly, is high in bioavailability, stable in product quality and small in irritation to the nasal cavity, and can be used as an antihistamine drug.

The present invention relates to the field of medicine technology and is one externally applied form of Cetirizine hydrochloride gel as one histamine resisting medicine and its preparation. The present invention prepares the gel with Cetirizine hydrochloride as main medicine component and different supplementary material, and the gel is administrated via skin or mucous membrane. The present invention can avoid liver reaction and stimulation to gstrointestinal tract of the medicine, reduce medicine concentration in blood, reduce central nerve suppressing effect, raise the medicine concentration in local affected part, decrease the administration times and raise patient's compatibility.

The invention discloses an external application formula for herpes zoster to solve the problem of treatment of herpes zoster. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1-5 parts of paris polyphylla, 1-5 parts of hibiscus mutabilis, 1-5 parts of cyrtomium fortunei, 1-5 parts of cortex pseudolaricis, 1-5 parts of wild buckwheat rhizome, 3-5 parts of prepared frankincense, 3-5 parts of prepared myrrh, 5-10 parts of golden cypress, 5-10 parts of coptis chinensis and 5-10 parts of rheum officinale. Clinical results prove that the composition for treating herpes zoster has the characteristics of good curative effect and higher safety, and is worthy of clinical application and popularization.

The invention relates to the technical field of medicine, and relates to a new dosage form of an antihistamine drug, Cetirizine Hydrochloride, namely a cataplasm. Cetirizine hydrochloride is a commonly used clinical drug, and the existing dosage forms are oral dosage forms, such as tablets, capsules, solutions and the like. Because cetirizine hydrochloride has a central inhibitory effect, the patient has adverse reactions such as drowsiness, dizziness, and headache after oral administration of the drug. The present invention uses cetirizine hydrochloride as the main medicine, adds different auxiliary materials to make cataplasm, and administers it through the transdermal route, which can not only avoid the stimulation of the gastrointestinal tract caused by oral administration, reduce the blood drug concentration of the whole body, and reduce the concentration of the central nervous system. Inhibitory effect, increase the drug concentration in the local affected area, and has the advantages of reducing the number of administrations, being convenient to use, improving the compliance of patients with medication, etc., providing a new dosage form for the clinical application of cetirizine.

The invention discloses a periodic traditional Chinese medicine patch for treating gynecological diseases. servings, 2-12 servings of cinnamon sticks or cinnamon. The preparation method of the traditional Chinese medicine patch for the treatment of gynecological diseases in cycles, comprising the following steps: (1) each raw material is weighed according to the parts by weight of the traditional Chinese medicine patches for the treatment of gynecological diseases; (2) the raw materials other than ginger juice are mixed , then grind and sieve to obtain the mixed medicinal powder; (3) mix the mixed medicinal powder with ginger juice, and then press it into medicinal cake to obtain the traditional Chinese medicine patch. The traditional Chinese medicine patch in the present invention can be applied for different symptoms before and after ovulation, can avoid the stimulation and toxic side effects of the oral drug on the gastric tract, and has the dual therapeutic effects of drug percutaneous absorption and stimulation of meridian and acupoints, with significant curative effect and low side effects. , easy to use.

The invention relates to a novel gynecological Qianjin zedoary turmeric oil suppository. The preparation method comprises the following steps: (1) taking raw materials: radix flemingiae macrophyllae, radix rosae laevigatae, caulis mahoniae, caulis spatholobi, radix zanthoxylum echinocarpum, herba andrographis, radix codonopsis, radix angelicae sinensis and zedoary turmeric oil; (2) preparing extractives; (3) heating and melting polyethylene glycol 6000 and poloxamer 188 in water bath, adding tween-80, the zedoary turmeric oil and extractives, stirring evenly and fully, keeping warm, pouring into a suppository mold coated with liquid paraffin on the surface, and obtaining the Qianjin zedoary turmeric oil suppository after cooling. According to the novel gynecological Qianjin zedoary turmeric oil suppository, drug parts of gynecological Qianjin capsules are integrated with the zedoary turmeric oil to prepare the suppository, plugging the suppository into a vaginal can treat vaginitis and cervicitis; plugging the suppository into a rectum can treat dysmenorrhea, amenorrhea, soreness of waist, annexitis, endometritis, chronic pelvic inflammatory disease and the like, and the suppository can also be used in a menstrual period. Rectal blood circulation is very rich, the drug does not pass through an upper gastrointestinal tract after the suppository is used, gastrointestinal irritation is avoided, the drug can be quickly absorbed to reach a pelvic cavity and plays a therapeutic effect, and obvious toxic and side effects are avoided.

The invention discloses a local medicine preparation with cinacalcet. The local medicine preparation comprises the following components: 1% of cinacalcet, 0-10% of a penetrant, 0-20% of a solvent and84-94% of a matrix. The local medicine preparation with the cinacalcet is prepared by dissolving the cinacalcet, the penetrant and the matrix into the solvent, heating the components to 55 DEG C, stirring and mixing the components, and cooling the mixture to the room temperature. By adopting a local drug delivery mode, gastrointestinal tract irritation caused by orally taken medicines can be avoided, a high medicine concentration can be maintained in local action tissue, the treatment effect can be improved, side reactions of a whole body can be avoided, and remarkable clinical advantages canbe achieved.

The invention discloses an insole with a treatment function, belongs to the technical field of health care products, and can solve the problem that an existing insole structure is poor in treatment effect on a human body. The insole comprises an insole main body and a medicine box arranged on the insole main body; the medicine box is fixed to the surface, making contact with the foot of the humanbody, of the insole main body. And the medicine box corresponds to the Yongquan acupoint of the foot of a human body. The invention is used for the insole.

The invention provides a traditional Chinese medicinal preparation for treating prostatitis and a preparation method thereof. The traditional Chinese medicinal preparation is prepared from the following raw medicinal materials in parts by weight: 10-20 parts of cowherb seed, 10-20 parts of tabasheer, 10-20 parts of polygonum cuspidatum, 10-20 parts of myrrh, 10-20 parts of rhizoma bolbostemmae, 10-20 parts of sharpleaf galangal fruit and 1-10 parts of nidus vespae. The preparation has the advantages of high bioavailability and good treatment effect.

The present invention relates to medicine technology, and is Granisetron cataplasm as 5-HT3 receptor agonist in new form. Granisetron is applied clinically in preventing and treating nausea, vomiting, etc caused by cytotoxicity treatment, and available Granisetron preparation forms have some demerits. The present invention prepares Granisetron into cataplasm with the hydrochloride or free alkali of Granisetron as main medicine component and some supplementary materials. The Granisetron cataplasm with transdermal administration has no first pass effect, reduced and constant systemic blood medicine concentration, less side effect, raised compliance and other advantages.

The invention discloses an eczema care solution which is applied to the treatment of eczema. The eczema care solution is characterized by being prepared from a plurality of traditional Chinese medicines, and contains the following raw pharmaceutical materials in parts by weight: 10-20 parts of honeysuckle stem, 10-20 parts of dahurian angelica root, 15-20 parts of cortex dictamni, 10-15 parts of cocklebur fruit, 1-3 parts of chaulmoogra, 10-15 parts of five-leaf akebia fruit, 10-20 parts of red peony root, 6-12 parts of codonopsis lanceolata, 6-12 parts of polygonum orientale fruit, 6-12 parts of chinaroot greenbrier, 10-15 parts of buchnera cruciata and 6-12 parts of verbena. Proved by clinical trials, the eczema care solution has the characteristics of good treatment effect and relatively high safety in the treatment of eczema, so that the eczema care solution is worthy of clinical application and popularization.

The invention relates to medicinal liquor and especially relates to and discloses externally-used medicinal liquor for treating ischemic heart disease. The medicinal liquor is prepared by soaking medicines including monkshood, cinnamon, achyranthes bidentata, gentiana macrophylla, mulberry twigs, aconitum gymnandrum, angelica pubescens, red peony roots, uncaria tomentosa, scorpions, bombyx batryticatus, earthworm, fresh ginger and radix glycyrrhizae in liquor. According to traditional Chinese medicine theories, the medicinal liquor is prepared through a combination formula according to relationships among monarch drugs, minister drugs, assistant drugs and guide drugs on the basis of functions of the medicines so that the effects of the medicines can be achieved in a cooperation manner. The medicinal liquor has main effects of freeing yang and opening paralysis and freeing collaterals and relieving pains and is mainly used for treating acute myocardial infarction, unstable angina pectoris and the like.

The invention discloses nursing liquid for eczema. By the nursing liquid, the problem of the treatment of the eczema is solved. The nursing liquid is characterized by being prepared from the following Chinese herbal medicines in part by weight: 10 to 20 parts of japanese honeysuckle stem, 10 to 20 parts of angelica dahurica, 15 to 20 parts of densefruit pittany root-bark, 10 to 15 parts of Siberian cocklour fruit, 1 to 3 parts of chaulmoogratree seed, 10 to 15 parts of akebia fruit, 10 to 20 parts of red paeony root, 6 to 12 parts of lanceolate codonopsis root, 6 to 12 parts of fruit of princesplume ladysthumb, 6 to 12 parts of smilax, 10 to 15 parts of buchnera and 6 to 12 parts of european verbena. Clinical experiments prove that the nursing liquid for treating the eczema has the characteristics of good curative effect and high safety, and is worthy of clinical application and popularization.

The invention belongs to the technical field of medicine, and specifically discloses a lurasidone self-microemulsion composition and a preparation method thereof. In parts by weight, 0.1 to 20 parts of lurasidone, 5 to 70 parts of an oil phase, and an emulsifier 10-70 parts, and 0-50 parts of co-emulsifier; when the self-microemulsion composition of lurasidone contacts with an aqueous medium, it forms and releases a microemulsion. The present invention adopts lurasidone free base as raw material drug, prepares lurasidone self-microemulsion composition, improves the solubility of fat-soluble excipients, improves the drug loading capacity of self-microemulsion carrier, and reduces gastrointestinal irritation and other side effects .