32results about How to "Avoid gastrointestinal irritation" patented technology

The invention belongs to the preparation field of western medicines and particularly relates to a high-efficiency and quick-acting phentolamine external preparation which takes natural plant naphtha and the extraction elaboration product thereof as a transdermal sorbefacient and a preparation method thereof. The invention selects the transdermal sorbefacient of natural volatile oils, takes phentolamine as the main active substance which plays a role in treatment in the preparation and is added with the accessories necessary in pharmacy, so as to prepare the phentolamine external transdermal preparation. Proved by experimentation on animals, the preparation can largely reduce the medication dosage and lower the systemic side effect and use cost when simultaneously maintaining the effectiveness of drugs. Compared with the prior art, the preparation can significantly improve the transdermal drug absorption amount of phentolamine, and shorten latent period of onset, has good medication safety and can offer patients more satisfactory curative effect.

The invention discloses a compound aloetic bacteriostatic traditional Chinese medicine film and a preparation method thereof. The compound aloetic bacteriostatic traditional Chinese medicine film comprises the following components in parts by weight: 15-25 parts of chitosan, 5-100 parts of traditional Chinese medicine effective constituents and 1-2 parts of glycerin, wherein the traditional Chinese medicine effective constituents include 28-55 parts of aloe extracting solutions, 20-40 parts of bletilla striata extracting solutions and 1-15 parts of radix ampelopsis extracting solutions. The compound aloetic bacteriostatic traditional Chinese medicine film has bacteriostatic effects of different degrees on staphylococcus aureus, staphylococcus epidermidis and colon bacillus, is prepared from natural pure traditional Chinese medicines, has the advantages of softness, transparency, safety, high hydrophilicity and ventilation property, no irritation, and the like, not only can resist bacteria and diminish inflammation, but also can eliminate swelling and promote granulation, thereby preventing the weakness of drug fastness caused by using antibiotics for a long time and being beneficial to healing a wound surface; in addition, the discloses a compound aloetic bacteriostatic traditional Chinese medicine film used as an adjuvant therapy medicine for ulcer, bedsore, skin or mucosa infection and minor operation incision infection on clinic has very well application prospect.

The invention relates to medicinal liquor and especially relates to and discloses externally-used medicinal liquor for treating ischemic heart disease. The medicinal liquor is prepared by soaking medicines including monkshood, cinnamon, achyranthes bidentata, gentiana macrophylla, mulberry twigs, aconitum gymnandrum, angelica pubescens, red peony roots, uncaria tomentosa, scorpions, bombyx batryticatus, earthworm, fresh ginger and radix glycyrrhizae in liquor. According to traditional Chinese medicine theories, the medicinal liquor is prepared through a combination formula according to relationships among monarch drugs, minister drugs, assistant drugs and guide drugs on the basis of functions of the medicines so that the effects of the medicines can be achieved in a cooperation manner. The medicinal liquor has main effects of freeing yang and opening paralysis and freeing collaterals and relieving pains and is mainly used for treating acute myocardial infarction, unstable angina pectoris and the like.

The invention discloses a traditional Chinese medicine plaster for treating gynecological blood stasis syndrome, which is prepared by the following method: grinding three-lens, curcuma, asarum, frankincense, myrrh, and paojiang into a medicinal powder, and making a thick paste with ginger juice. Medicine cake. The traditional Chinese medicine application of the present invention has remarkable clinical curative effect in treating gynecological blood stasis syndrome, has a high total effective rate, can effectively improve the symptoms of abdominal pain or pelvic pain during menstruation, and can effectively improve aversion to cold and warmth, mental fatigue, lack of energy, lazy speech, and spontaneous sweating , urine leakage or incontinence, back pain, shin soreness, soft knees, or heel pain are symptoms of gynecological blood stasis syndrome caused by deficiency and cold. The treatment by application can avoid gastrointestinal stimulation and toxic side effects of oral medicines, has dual therapeutic effects of percutaneous absorption of medicines and stimulation of meridians and acupoints, has remarkable curative effect, low side effects, and is convenient to use.

The present invention relates to the field of medicine technology and is one externally applied form of Cetirizine hydrochloride gel as one histamine resisting medicine and its preparation. The present invention prepares the gel with Cetirizine hydrochloride as main medicine component and different supplementary material, and the gel is administrated via skin or mucous membrane. The present invention can avoid liver reaction and stimulation to gstrointestinal tract of the medicine, reduce medicine concentration in blood, reduce central nerve suppressing effect, raise the medicine concentration in local affected part, decrease the administration times and raise patient's compatibility.

The invention relates to the technical field of medicine, and relates to a new dosage form of an antihistamine drug, Cetirizine Hydrochloride, namely a cataplasm. Cetirizine hydrochloride is a commonly used clinical drug, and the existing dosage forms are oral dosage forms, such as tablets, capsules, solutions and the like. Because cetirizine hydrochloride has a central inhibitory effect, the patient has adverse reactions such as drowsiness, dizziness, and headache after oral administration of the drug. The present invention uses cetirizine hydrochloride as the main medicine, adds different auxiliary materials to make cataplasm, and administers it through the transdermal route, which can not only avoid the stimulation of the gastrointestinal tract caused by oral administration, reduce the blood drug concentration of the whole body, and reduce the concentration of the central nervous system. Inhibitory effect, increase the drug concentration in the local affected area, and has the advantages of reducing the number of administrations, being convenient to use, improving the compliance of patients with medication, etc., providing a new dosage form for the clinical application of cetirizine.

The invention discloses a periodic traditional Chinese medicine patch for treating gynecological diseases. servings, 2-12 servings of cinnamon sticks or cinnamon. The preparation method of the traditional Chinese medicine patch for the treatment of gynecological diseases in cycles, comprising the following steps: (1) each raw material is weighed according to the parts by weight of the traditional Chinese medicine patches for the treatment of gynecological diseases; (2) the raw materials other than ginger juice are mixed , then grind and sieve to obtain the mixed medicinal powder; (3) mix the mixed medicinal powder with ginger juice, and then press it into medicinal cake to obtain the traditional Chinese medicine patch. The traditional Chinese medicine patch in the present invention can be applied for different symptoms before and after ovulation, can avoid the stimulation and toxic side effects of the oral drug on the gastric tract, and has the dual therapeutic effects of drug percutaneous absorption and stimulation of meridian and acupoints, with significant curative effect and low side effects. , easy to use.

The invention relates to a novel gynecological Qianjin zedoary turmeric oil suppository. The preparation method comprises the following steps: (1) taking raw materials: radix flemingiae macrophyllae, radix rosae laevigatae, caulis mahoniae, caulis spatholobi, radix zanthoxylum echinocarpum, herba andrographis, radix codonopsis, radix angelicae sinensis and zedoary turmeric oil; (2) preparing extractives; (3) heating and melting polyethylene glycol 6000 and poloxamer 188 in water bath, adding tween-80, the zedoary turmeric oil and extractives, stirring evenly and fully, keeping warm, pouring into a suppository mold coated with liquid paraffin on the surface, and obtaining the Qianjin zedoary turmeric oil suppository after cooling. According to the novel gynecological Qianjin zedoary turmeric oil suppository, drug parts of gynecological Qianjin capsules are integrated with the zedoary turmeric oil to prepare the suppository, plugging the suppository into a vaginal can treat vaginitis and cervicitis; plugging the suppository into a rectum can treat dysmenorrhea, amenorrhea, soreness of waist, annexitis, endometritis, chronic pelvic inflammatory disease and the like, and the suppository can also be used in a menstrual period. Rectal blood circulation is very rich, the drug does not pass through an upper gastrointestinal tract after the suppository is used, gastrointestinal irritation is avoided, the drug can be quickly absorbed to reach a pelvic cavity and plays a therapeutic effect, and obvious toxic and side effects are avoided.

The invention discloses an insole with a treatment function, belongs to the technical field of health care products, and can solve the problem that an existing insole structure is poor in treatment effect on a human body. The insole comprises an insole main body and a medicine box arranged on the insole main body; the medicine box is fixed to the surface, making contact with the foot of the humanbody, of the insole main body. And the medicine box corresponds to the Yongquan acupoint of the foot of a human body. The invention is used for the insole.

The present invention relates to medicine technology, and is Granisetron cataplasm as 5-HT3 receptor agonist in new form. Granisetron is applied clinically in preventing and treating nausea, vomiting, etc caused by cytotoxicity treatment, and available Granisetron preparation forms have some demerits. The present invention prepares Granisetron into cataplasm with the hydrochloride or free alkali of Granisetron as main medicine component and some supplementary materials. The Granisetron cataplasm with transdermal administration has no first pass effect, reduced and constant systemic blood medicine concentration, less side effect, raised compliance and other advantages.

The invention discloses nursing liquid for eczema. By the nursing liquid, the problem of the treatment of the eczema is solved. The nursing liquid is characterized by being prepared from the following Chinese herbal medicines in part by weight: 10 to 20 parts of japanese honeysuckle stem, 10 to 20 parts of angelica dahurica, 15 to 20 parts of densefruit pittany root-bark, 10 to 15 parts of Siberian cocklour fruit, 1 to 3 parts of chaulmoogratree seed, 10 to 15 parts of akebia fruit, 10 to 20 parts of red paeony root, 6 to 12 parts of lanceolate codonopsis root, 6 to 12 parts of fruit of princesplume ladysthumb, 6 to 12 parts of smilax, 10 to 15 parts of buchnera and 6 to 12 parts of european verbena. Clinical experiments prove that the nursing liquid for treating the eczema has the characteristics of good curative effect and high safety, and is worthy of clinical application and popularization.

The invention belongs to the technical field of medicine, and specifically discloses a lurasidone self-microemulsion composition and a preparation method thereof. In parts by weight, 0.1 to 20 parts of lurasidone, 5 to 70 parts of an oil phase, and an emulsifier 10-70 parts, and 0-50 parts of co-emulsifier; when the self-microemulsion composition of lurasidone contacts with an aqueous medium, it forms and releases a microemulsion. The present invention adopts lurasidone free base as raw material drug, prepares lurasidone self-microemulsion composition, improves the solubility of fat-soluble excipients, improves the drug loading capacity of self-microemulsion carrier, and reduces gastrointestinal irritation and other side effects .