Cetirizine and pseudoephedrine sustained-release capsule and preparation method thereof

Abstract

The invention discloses a cetirizine pseudoephedrine slow release capsule. Cetirizine hydrochloride is prepared to quick release pellets and pseudoephedrine hydrochloride is prepared to slow release pellets, in accordance with the weight proportion that each 1000 preparations contain 5g of cetirizine hydrochloride and 120g of pseudoephedrine hydrochloride, the two pellets are uniformly mixed and encapsulated; or the two pellets are encapsulated respectively in proportion. The quick release part of the cetirizine hydrochloride and the slow release part of the pseudoephedrine hydrochloride are synthesized together subsequent to being prepared to the pellets respectively, so as to prepare the capsule with two different medicine-releasing speeds, the medicine-releasing speed of each pellet is uniform and the medicine effect is steady. The capsule has the advantages of even and extensive distribution of the medicine in vivo subsequent to the administering, sufficient absorption of the medicine, small stimulation to gastrointestinal tracts and good reproducibility of the medicine-releasing rule, and improves, while maintaining the properties of rapid effecting and long half-life of the cetirizine, the pharmacokinetic properties of the pseudoephedrine hydrochloride to administer twice per day instead of having to administer four times per day, so that both reach the optimal cooperative curative effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular a cetirizine-pseudoephedrine slow-release capsule composed of a cetirizine hydrochloride quick-release preparation and a pseudoephedrine hydrochloride slow-release preparation and a preparation method thereof. Background technique [0002] According to statistics, about 59% of the population suffers from seasonal and perennial allergies, of which 30% are accompanied by nasal congestion. The cause is often due to exposure to allergens, which can lead to the production of specific IgE antibodies that bind to columnar cells and Basophil receptors, which in turn cause the release of histamine and other inflammatory mediators from mast cells and basophils, resulting in an immediate or early allergic reaction. Allergic rhinitis is a relatively common seasonal or long-term disease, and its clinical symptoms include nasal congestion, airflow obstruction, rhinorrhea, sneezing, itch...

AI Technical Summary

Problems solved by technology

Although the problem of rapid release of cetirizine and sustained release of pseudoephedrine hydrochloride has been solved, the inner and outer tablets cannot release the drug effect at the same time

Chinese patent application number 200710179843.2 discloses a "cetirizine pseudoephedrine sustained-release capsule" technology, which is to first make quick-release microtablets of cetirizine hydrochloride and slow-release microtablets of pseudoephedrine hydrochloride, and then combine the two The micro-tablets are loaded into the capsule according to the ratio. Although the two drugs can release the drug effect at the same time, the volume of the two micro-tablets is relatively large, the shape is irregular, and it is inconvenient to fill, which may easily cause uneven drug release and unstable drug effect. , in addition, the process is complicated and the processing cycle is long

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