Cetirizing hydrochloride cataplasm preparation

A technology of cetirizine hydrochloride and hydrochloric acid, which is applied in the field of medicine to achieve the effects of reducing blood drug concentration, convenient use, and reducing the number of administrations

Inactive Publication Date: 2003-11-26
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with other antihistamines, although the central nervous system activity of cetirizine hydrochlor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 prepares cetirizine hydrochloride cataplasm

[0012] Formula and ratio:

[0013] Gelatin 2g Carborite7S 0.4g

[0014] Sodium Carboxymethyl Cellulose 4g Ca(OH) 2 0.24g

[0015] Polyvinylpyrrolidone 6g Propylene glycol 20ml

[0016] D-Sorbitol 38g Kaolin 4g

[0017] 60ml distilled water 8g menthol

[0018] Glycerin 8ml Citric acid (10%) 0.5ml

[0019] Polyethylene glycol-200 1g Cetirizine hydrochloride 0.6g

[0020] The preparation method is:

[0021] 1. Prepare (I) phase solution: fully swell the gelatin with water according to the above ratio, dissolve it in a water bath at 60°C, mix the sodium carboxymethylcellulose, polyvinylpyrrolidone, and D-sorbitol evenly, and then add it to the gelatin solution. Stir to obtain (I) phase solution.

[0022] 2. Prepare (II) phase solution: dissolve menthol in propylene glycol, mix with Carborite7S, Ca(OH) 2 , kaolin, citric acid, and cetirizine hydrochloride are un...

Embodiment 2

[0024] Embodiment 2 Preparation of cetirizine hydrochloride cataplasm

[0025] Formula and ratio:

[0026] Gelatin 2g Carborite7S 0.2g

[0027] Sodium Carboxymethyl Cellulose 4g Al(OH) 3 0.18g

[0028] Polyvinylpyrrolidone 4g Propylene Glycol 20ml

[0029] D-Sorbitol 32g Zinc Oxide 4g

[0030] Distilled water 60ml Camphor 6g

[0031] Glycerin 10ml Citric acid (20%) 0.4ml

[0032] Isopropanol 1g Cetirizine Hydrochloride 0.6g

[0033] The preparation method is:

[0034] 1, prepare (I) phase solution (same as embodiment 1).

[0035] 2. Prepare (II) phase solution: dissolve camphor in propylene glycol, add Carborite7S, Al(OH) 3 , zinc oxide, citric acid, and cetirizine hydrochloride were uniformly mixed to obtain (II) phase solution.

[0036] 3. Mix (I) and (II) phase solutions, add 10ml glycerin, 1g isopropanol, stir well, spread on 150×240cm 2 On non-woven fabric, bake at 50°C for 30 minutes, cover with anti-adhesive film,...

Embodiment 3

[0037] Embodiment 3 prepares cetirizine hydrochloride cataplasm

[0038] Formula and ratio:

[0039] Gelatin 2g Carborite7S 0.6g

[0040] Sodium carboxymethylcellulose 3g AlCl 3 0.2g

[0041] Polyvinylpyrrolidone 6g Propylene glycol 20ml

[0042] D-Sorbitol 36g Kaolin 6g

[0043] Distilled water 80ml Azone 8g

[0044] Glycerin 10ml Citric acid (50%) 0.2ml

[0045] Oleic acid 0.5g Cetirizine hydrochloride 0.6g

[0046] The preparation method is:

[0047] 1, prepare (I) phase solution (same as embodiment 1).

[0048] 2. Prepare II) phase solution: mix azone, propylene glycol with Carborite7S, AlCl 3 , kaolin, citric acid, and cetirizine hydrochloride are uniformly mixed to obtain (II) phase solution.

[0049] 3. Mix (I) and (II) phase solutions, add 10ml glycerin, 0.5g oleic acid, stir well, spread on 150×240cm 2 On non-woven fabric, bake at 50°C for 30 minutes, cover with anti-adhesive film, cut into 5×8cm 2 The catapl...

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PUM

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Abstract

The present invention relates to medicine technology and is cataplasm as one new form of Cetirizine hydrochloride. There are available oral forms of Cetirizine hydrochloride, such as tablet, capsule, solution preparation, etc. The present invention prepares the cataplasm with Cetirizine hydrochloride as main medicine component and different supplementary material, and the cataplasm is administrated via skin. The present invention can avoid stimulation to gastrointestinal tract of the medicine, reduce medicine concentration in blood, reduce central nerve suppressing effect, raise the medicine concentration in local affected part, decrease the administration times and raise patient's compatibility.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to a new dosage form of the antihistamine cetirizine hydrochloride—a cataplasm. Background technique: [0002] Cetirizine hydrochloride is a second-generation antihistamine, which has a good therapeutic effect on allergic diseases of the skin, respiratory system and eyes, such as skin urticaria, allergic asthma, allergic rhinitis and allergic conjunctivitis. At present, the pharmaceutical dosage forms of this medicine include conventional dosage forms such as tablets, capsules, and solutions, and the route of administration is all oral. Compared with other antihistamines, although the central nervous system activity of cetirizine hydrochloride is lower, the drug still has adverse reactions such as drowsiness, dizziness, and headache when taken orally. Invention content: [0003] The invention provides a transdermal drug delivery preparation of cetirizine hydrochloride - cataplasm...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/495A61K47/30A61P37/08
Inventor 胡晋红刘继勇童华朱全刚
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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