86results about How to "Lower blood levels" patented technology

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

The invention relates to the field of Chinese medicine, and discloses a Chinese medicinal composition for preventing and treating asthenopia. The composition comprises wild chrysanthemums, red sage roots, pearls, borneol and menthol. The Chinese medicinal composition preferably comprises the following in part by weight: 450 to 490 parts of wild chrysanthemums, 280 to 310 parts of red sage roots, 33 to 39 parts of pearls, 5 to 9 parts of borneol and 5 to 9 parts of menthol. The invention also provides a wet application of the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition has the advantages of dredging blocked capillaries and increasing supply of eye nutrition, along with easy absorption, quick response, good curative effect and good application prospects.

Embodiments provide an apparatus, system, kit and method for in vivo measurement of blood oxygen saturation (BAS). One embodiment provides an implantable apparatus for measuring BAS comprising a housing, emitter, detector, processor and power source. The housing is configured to be injected through a tissue penetrating device into a target tissue site (TS). The emitter is configured to emit light into the TS to measure BAS, the emitted light having at least one wavelength (LOW) whose absorbance is related to a BAS. The detector is configured to receive light reflected from the TS, detect light at the LOW and generate a detector output signal (DOS) responsive to an intensity of the detected light. The processor is operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the DOS and includes logic for calculating a BAS and generate a signal encoding the BAS.

The invention relates to a tablet of isosorbide mononitrate, in particular to a double-layer osmotic pump controlled release tablet of isosorbide mononitrate, which belongs to the field of medicine preparation. A single-chamber double-layer osmotic pump tablet of the isosorbide mononitrate is characterized in that a semi-transparent coating film cover a double-layer core body consisting of a medicine-containing layer and a boosting layer; and the coating film is provided with a medicine releasing pore on the surface of the medicine-containing layer. The gastrointestinal tract water enters a double-layer tablet chip through the semi-transparent film; the medicines forms a mixed suspension liquid or solution when contacting water in the medicine-containing layer; a penetration enhancer enables the solution of the medicine-containing layer to be hypertonic so that an osmotic pressure difference exists between the inner side and the outer side of the film, which is beneficial to pumping the medicines out; and the pressure is generated in the boosting layer through water absorption, dissolution and expansion of a penetrating agent so as to further boost a medicine liquid to eject the pore.

A PLGA gemcitabine slow release microball is disclosed in the present invention belonging to pharmaceutical field. The PLGA gemcitabine slow release microball is prepared by supplementary polylactic acid-glycolic acid and raw material medicine gemcitabine with the weight ratio of 95 :5 to 35 :65. The present invention has the advantages that: preparing gemcitabine and polylactic acid-glycolic acid into slow release microball, directly sendint to tumor part by syringe to execute regional slow release chemotherapy, gemcitabine are released slowly, the tumor part has high medicine concentration, long duration, strong action intensity, big killing force to tumor cell, thereby can improve curative effect to tumor; medicine are centralized to act on local, whole body has little medicine amount, adverse response is minimal. After medicine are released, polylactic acid-glycolic acid start to degradate as lactic acid and glycolic acid, further degradate as carbon dioxide and water, no effect to human body.

The present invention relates to the field of medicine technology and is one externally applied form of Cetirizine hydrochloride gel as one histamine resisting medicine and its preparation. The present invention prepares the gel with Cetirizine hydrochloride as main medicine component and different supplementary material, and the gel is administrated via skin or mucous membrane. The present invention can avoid liver reaction and stimulation to gstrointestinal tract of the medicine, reduce medicine concentration in blood, reduce central nerve suppressing effect, raise the medicine concentration in local affected part, decrease the administration times and raise patient's compatibility.

The invention relates to a method for preparing temperature-sensitive aquagel hollow fiber, wherein it uses hollow fiber as carrier, whose chamber contains temperature-sensitive aquagel; the aquagel will change phase at human temperature to release the drug. And the preparation comprises a, holding the holes of hollow fiber; b, putting temperature-sensitive monomer solution into the chamber of hollow fiber; c, compositing temperature-sensitive aquagel in the chamber; d, using said aquagel to absorb drub. The invention has better temperature-sensitive property and slow-release property.

The invention relates to a remdesivir liquid preparation for an atomizer, a preparation method and application of the remdesivir liquid preparation, and belongs to the field of medicines. The remdesivir liquid preparation for the atomizer comprises 1 mg-100 mg / ml of remdesivir, a solubilizing assistant not greater than 200 mg / ml and / or a cosolvent not greater than 0.5ml / ml, and the balance of a hydrosolvent, wherein the pH value is adjusted to be 3-7. The remdesivir liquid preparation for the atomizer is an inhalation type spray. The upper respiratory tract is the most common virus infection part of a novel coronavirus in early epidemic disease. Remdesivir is directly acted on infected original parts including a nasal cavity, an oral cavity and lung inhalation cavity mucosa by using the atomized and inhaled solution, so that the medication of a pneumonia patient infected by the novel coronavirus is more targeted and touchable, and the systemic exposure of the medicine in the body is reduced. Meanwhile, the added solubilizing assistant can avoid the defect of bitter taste, and the taste is mild after inhalation, so that the remdesivir liquid preparation is more suitable for being orally taken by juveniles, pregnant women and elder people.

A Chinese medicine in the form of capsule, tablet, or particle for regulating blood sugar and blood fat is proportionally prepared from 7 Chinese-medicinal materials including gynostemma pentaphyllum, mulberry leaf, haw, notoginseng, etc. Its preparing process is also disclosed. Its advantages are high effect to decrease blood sugar, cholesterol and triglyceride, and low poison.

The present invention provides a lactobacillus strain-containing pharmaceutical composition and food composition for improving of kidney disease and inhibiting inflammation, which comprises an isolated lactic acid bacteria strain. The isolated lactic acid bacteria strain is at least one selected from a group including BLI-02 strain, CGMCC No. 15212, Bifidobacterium longum subsp. infantis, TYCA06 strain, CGMCC No. 15210, Lactobacillus acidophilus, VDD088 strain, CGMCC No. 15211, Bifidobacterium bifidum, and combinations thereof.

The present invention relates to a pharmaceutical composition or a kit comprising, a first substance capable of raising intracellular cAMP levels, and a second substance capable of modulating intracellular calcium concentration.Likewise, the present invention relates to methods of treating patients suffering from autism spectrum disorder (ASD) phenotype 1 by administering an effective amount of a substance capable of raising intracellular cAMP levels and, optionally, an effective amount of a substance capable of modulating intracellular calcium concentration.

The present invention relates to a contraception medicament and pharmacy field. The compound contraceptive medicament is prepared to a biological degradation type long-effect microsphere preparation for injection. The invention settles the problems of large side effect, inferior compliance property and liver-kidney function effect of prior oral contraceptive medicament, and complicated using method, large side effect, etc. of traditional unilateral abiotic degradation type long-effect contraception implantation agent. The invention provides a long-term compound contraception microsphere injection which has the advantages of good contraception effect, small side effect and easy use, and a preparing method thereof. The microsphere comprises gestodene, estrogen and biological degradation polymer. The detailed content is in the instruction book. The product of the invention can stably and synchronously release two effective components in a long time. The inside and outside relativity of effective component is excellent.

The invention relates to a traditional Chinese medicine gel for treating arthritis and preparation method thereof, belonging to medical field. The gel is composed of raw sihcuan axonite root extract and pharmaceutical adjuvant by the following weight ratio: raw sihcuan axonite root extract 1.5%, camphor 0.1%, musk 0.04%, high molecular matrix material 0.1-5%, humectant 5-15%, preservatives 0-0.5%, solvent 50-80%.

The invention, relating to the technical field of medicine, provides a Chinese-medicinal compound lotion for treating dermatitis eczema and a preparation method thereof. The component proportion of the lotion is: 50-70g of sophora flavescens, 40-60g of common cnidium fruit, 20-40g of phellodendron, 25-35g of Chinese angelica, 15-25g of Ligusticum wallichii, 15-30g of rheum officinale, 3-6g of borneol, and 0.1wt% of antiseptic ethylparaben. The preparation method comprises the following steps: 1) preparing an extract of sophora flavescens, common cnidium fruit and phellodendron; 2) preparing an extract of Chinese angelica, Ligusticum wallichii and rheum officinale; 3) mixing the extracts obtained by step 1) and 2), adding borneol according to the proportion and 0.1wt% of antiseptic ethylparaben, adding water until the amount of the mixture reaches to 1000ml for dilution, and sub-packaging. The lotion can avoid the irritation on gastrointestinal tracts by oral administration, reduce the blood concentration of body and reduce side effects through the transdermal drug delivery. The preparation method is simple, and the lotion is easy to operate and improves the compliance of medicine. The invention provides a novel medicinal preparation for treating dermatitis eczema.

The invention provides a method for processing rice with remained germs into three sections, a product and applications, and relates to a method for processing rice grains with rice husks or brown rice grains with rice husks removed, and further relates to a product prepared with the processing method and applications of the product. The defect that germs are retained incompletely of germ rice obtained by transversely grinding the rice with remained germs at present is overcome. The method comprises the following steps: the rice grains or the brown rice grains are divided into three sections in the length direction by manual or mechanical processing, the rice grains of the sections at two ends are equal in length and the rice grains at one of the sections at two ends contain germs; the rice grains in the middle section are gathered together, and the rice grains at the two ends are gathered together; the rice grains in the middle section are subjected to aleurone layer removal; meanwhile, rice husks remaining on the rice grains at two ends are removed. The provided product comprises the rice grains in the middle section and the rice grains at two ends, the rice grains in the middlesection are subjected to aleurone layer removal by grinding, and the rice grains at two ends are subjected to husk removal and are hemispherical, conical or flat conical. The invention further provides the applications of the product to steaming of rice and cooking of porridge or rice paste.

An excellent medicine for the treatment or prevention of hypertension or the like is provided. A specific acid addition salt of (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3- yl)ester 5-isopropyl ester is useful as a medicine for the treatment or prevention of hypertension or the like.

The invention relates to an isosorbide mononitrate osmotic pump type controlled-release preparation and a preparation method thereof. The preparation can release the isosorbide mononitrate at a constant medicament release rate. The preparation mainly comprises a tablet core, a semipermeable coating film and medicament release pores, wherein the tablet core is prepared from the isosorbide mononitrate, a penetrating agent, a filling agent and other pharmaceutic adjuvants; and the semipermeable coating film is prepared from cellulose acetate or ethylcellulose, a plasticizer and a pore former. Theosmotic pressure on the inner side and the outer side of a semipermeable film is taken as a driving force, and a medicament is released at a zero level release rate to maintain stable internal bloodconcentration. The preparation has the characteristics of moderate internal medicament action time, small side effect, and less drug resistance for repeated dose.

The invention relates to a daphnetin slow-release composition and a preparation method thereof. The slow-release composition is a matrix tablet. The matrix tablet comprises daphnetin, filler, a matrix material, a bonding agent and a lubricating agent. The matrix material is a high-viscosity hydrophilic matrix material or a soluble matrix material. The daphnetin slow-release tablet prepared with the method has a good slow-release effect and is long in action time, low in dosage, low in frequency of taking and high in bioavailability in comparison with a capsule on the market. The process is simple in operation, low in cost and easy to control, and is suitable for industrial mass production.

The present invention discloses a biological medicine gel preparation for curing periodontal disease and its preparation method. Said gel preparation is made up by using (by wt%) 1.5%-2.5% of tetracycline antibiotic, 14%-16% of chitosan, 5%-7% of cardralazine, 24%-26% of glycerin, 1%-3% of teen 80 and 50% of distilled water through a certain preparation process.

The invention relates to an allicin vaginal suppository and a preparation method thereof. The allicin vaginal suppository comprises following components in percentages by weight: allicin 0.2-5%, substrate 20-79%, emulsifier 0.01-1%, acetic acid 0.1-15%, chitosan 0.1-10%, and distilled water 1-30%; wherein the sum of the percentages of the components is 100%, the substrate adopts glycerin and gelatin, or adopts polyethyleneglycol substances, and the polyethyleneglycol substances includes at least one of polyethyleneglycol 400, polyethyleneglycol 1000, polyethyleneglycol 1500 and polyethyleneglycol 4000; the emulsifier adopts tween substances, and the tween substances includes at least one of tween-80, tween-60 and tween-40. The invention further provides the preparation method of the allicin vaginal suppository; according to the allicin vaginal suppository, the gynecological inflammation can be treated effectively, synchronously the organism immunity of patients can be enhanced, the use of drugs is improved, the administration frequency is reduced, and the use is convenient.

The present invention belongs to the field of Chinese medicine technology, and is especially one kind of compounding Chinese gel preparation for treating osteoarthropathy and its preparation process. The Chinese gel preparation consists of raw aconite root extractive, datura flower extractive, camphor, musk, polymer as matrix, solvent, humectant, preservative and other supplementary material. Compared with available technology, the Chinese gel preparation for transdermal administration of the present invention has no irritation to gastrointestinal tract, lowered body blood medicine concentration, reduced toxic side effect, prolonged acting period, raised patient compliance to the medicine, easy use and low cost.

The present invention relates to a preparation method, uses and a use method of a dexamethasone implant for kidney, wherein the dexamethasone implant comprises dexamethasone or dexamethasone acetate, a degradable polymer material, and a water soluble auxiliary material. The preparation method comprises: crushing various materials, mixing, carrying out micro-spheroidization, carrying out mold pressing molding, and heating for a certain time at a proper temperature to prepare the cylindrical implant with a diameter of 0.2-0.9 mm and a length of 0.8-4 mm. According to the present invention, the implant has characteristics of smooth surface and uniform drug release in vivo, wherein the time for releasing 90% of the drug is 1 month to 1 year; and the implant can be implanted into the renal sac through a drug implanting needle so as to treat nephrotic syndrome, nephritis and other chronic kidney diseases.

The invention discloses a bortezomib pharmaceutical composition and applications thereof, wherein the bortezomib pharmaceutical composition comprises, by weight, 0.1-200 parts of bortezomib, 0.1-500 parts of an auxiliary material for adjusting release rate, 0-10 parts of a small molecule adjusting agent, and 0-2000 parts of a pharmaceutically acceptable injectable solvent. According to the presentinvention, the bortezomib pharmaceutical composition has the controlled drug release behavior, and can maintain the effective blood concentration and the proteasome inhibition level in the body; through the long-acting injection of the bortezomib pharmaceutical composition, the in vivo blood concentration and the efficacy providing of bortezomib can be controlled, the treatment effect of the drugcan e improved, the acting time can be prolonged, and the toxic-side effect of the drug can be reduced; the in vivo proteasome inhibition pharmaceutical composition with characteristics of high efficiency, long acting and low toxic-side effect is provided; and the invention further discloses uses of the bortezomib pharmaceutical composition in treatment of refractory / recurrent multiple myeloma.

The invention discloses a tizanidine hydrochloride sustained-release preparation and a preparation method thereof, wherein the tizanidine hydrochloride sustained-release preparation contains tizanidine hydrochloride, a sustained-release skeleton material, a filler, a binder and a glidant according to a certain ratio. According to the present invention, the tizanidine hydrochloride sustained-release preparation can maintain the sustained release effect for 24 h, can avoid the excessive fluctuation of blood drug concentration and improve medication safety, effectiveness and compliance after taking, and further can reduce side effects; and the preparation process is simple, and the controllability of the process is strong.

The invention relates to a medicinal composition of recombinant carboxypeptidase G2. The medicinal composition comprises a medicinal effective dosage of recombinant carboxypeptidase G2 proteins, a stabilizer, an excipient and a nonvolatile buffering agent for adjusting the pH value of a preparation to keeping optimal biological activity of the preparation. Every 1ml of recombinant carboxypeptidase G2 medicinal composition solution contains 500-2,000 U of recombinnt carboxypeptidase G2, 3-6 percent by weight volume of an excipient and 1-3 percent by weight volume of a stabilizer, a tri-methylolaminomethane-hydrochloric acid (Tris-HCl) buffering agent for adjusting the pH range to 6.8-7.8 and 0.1-0.5 mM of zinc chloride. A recombinant carboxypeptidase G2 lyophilized powder injection preparation has the beneficial effects that: under the pserving condition of 2-8 DEG C, the activity can be kept for 24 months, and the active structure of a natural dipolymer is kept. The preparation is aseptic, and can play a pharmacological action through intravenous injection.

The present invention provides a medicinal composition capable of preventing a decrease in the blood exposure level of a third generation coxib drug, a method for preparing the composition and utilization of the same. It was discovered that, by adding a basic amine or a basic amino acid or cyclodextrin to a third generation coxib compound, a medicinal composition capable of inhibiting a decrease in the blood concentration thereof, a decrease in the area under concentration thereof and a decrease in the bioavailability thereof can be obtained. In addition, the medicinal composition according to the present invention is highly stable and useful as a medicine. That is, a technical idea that a decrease in blood concentration, a decrease in area under concentration and a decrease in bioavailability can be inhibited by adding a basic amine or a basic amino acid or cyclodextrin is thus established.

The invention relates to the field of medicinal chemistry, in particular to an organic nitrite donor compound(structures shown in a general formula I and a general formula II)containing a 1nitromethyl2phenylethylene skeleton, a preparation method of the organic nitrite donor compound, and medical application of a medicinal composition of the compounds to prevention or treatment of cerebral ischemia, myocardial ischemia and pulmonary hypertension.

The invention relates to a VC transdermal patch and a preparation method of the VC transdermal patch. The VC transdermal patch is mainly composed of a substrate, a permeation promoter, a plasticizer and a main medicine, and is characterized in that the substrate is one or the combination of two of the following components: hydroxypropyl methylcellulose, carbomer, polyvinyl alcohol and sodium carboxymethyl cellulose; the permeation promoter is one or the combination of two of the following components: propylene glycol, azone, dimethyl sulofoxide and peppermint oil; the plasticizer is one or thecombination of two of the following components: propylene glycol, glycerol and polyethylene glycol. The VC transdermal patch provided by the invention is good in bioavailability, the medicine can release efficiently, and the use is safe, reliable and convenient. The invention aims at providing the VC transdermal patch and the preparation method of the VC transdermal patch, the preparation processis simple, the stability is good, and the large-scale industrial production can be easily realized.