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Allicin vaginal suppository and preparation method thereof

A vaginal suppository, allicin technology, applied in the directions of suppository delivery, antifungal agent, pharmaceutical formulation, etc., can solve the problems of no literature report and application, and achieve the effects of improving immunity, improving curative effect, and improving gynecological inflammation

Active Publication Date: 2012-01-04
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no literature reports and applications on the preparations for vaginal administration of allicin

Method used

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  • Allicin vaginal suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] This example adopts following weight components to prepare garlicin vaginal suppository,

[0038] Allicin: 40g;

[0039] Glycerin: 266g;

[0040] Gelatin: 76g;

[0041] Chitosan: 40g;

[0042] Acetic acid: adjust the pH value to 4.6-5.3;

[0043] Tween-80: 8ml;

[0044] Distilled water: 38ml.

[0045] The preparation method of this example is as follows: first, add the chitosan to acetic acid to swell and form chitosan gel; take 3 / 10~1 / 2 of the chitosan gel and add allicin respectively according to the above ratio and emulsifier, that is, add 40g of allicin and 8ml of Tween-80 respectively, and stir to make an emulsion; heat the base water bath to 75-85°C until the base melts, and adjust the base temperature to 40-50°C; The chitosan gel and the emulsion are added to the above-mentioned matrix, stirred evenly, poured into the suppository mold while it is hot, refrigerated, after taking it out, trim off the excess part, open the mold, and push out the suppository, a...

Embodiment 2

[0048] Different from Example 1, the acetic acid adjusts its pH value to 4.9; in the described preparation method, 2 / 5 of the chitosan gel is taken to add allicin and emulsifier respectively according to the above proportioning, that is, respectively 40 g of allicin and 8 ml of Tween-80 were added, and the matrix was heated in a water bath and adjusted to 45° C. In this example, 100 allicin vaginal suppositories were prepared.

[0049] The allicin vaginal suppository prepared in this example has high drug bioavailability, and at the same time, it can promote the regeneration, repair and healing of traumatic tissue, effectively treat gynecological inflammation, and improve the immune ability of the patient's body, which has positive significance for the treatment of gynecological diseases. The frequency of administration is reduced, the use is convenient, and the patient's compliance with medication is improved.

Embodiment 3

[0051] Different from Example 2, this example adopts the following weight components to prepare the allicin vaginal suppository,

[0052] Allicin: 40g;

[0053] Polyethylene glycol 400: 44.3g;

[0054] Polyethylene glycol 1000: 110.8g;

[0055] Polyethylene glycol 4000: 110.8g;

[0056] Chitosan: 40g;

[0057] Acetic acid: adjust the pH value to 4.9;

[0058] Tween-60: 8ml;

[0059] Distilled water: 38ml.

[0060] The preparation method of this example is consistent with that of Example 2. The difference is that in the preparation method, 2 / 5 of the chitosan gel is taken and 40g of allicin and 8ml of Tween-60 are added respectively to make 100 capsules. The allicin vaginal suppository described in this example has high drug bioavailability, and at the same time, promotes the regeneration, repair and healing of traumatic tissue, effectively treats gynecological inflammation, and improves the immune ability of the patient's body. The treatment of diseases has positive sig...

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Abstract

The invention relates to an allicin vaginal suppository and a preparation method thereof. The allicin vaginal suppository comprises following components in percentages by weight: allicin 0.2-5%, substrate 20-79%, emulsifier 0.01-1%, acetic acid 0.1-15%, chitosan 0.1-10%, and distilled water 1-30%; wherein the sum of the percentages of the components is 100%, the substrate adopts glycerin and gelatin, or adopts polyethyleneglycol substances, and the polyethyleneglycol substances includes at least one of polyethyleneglycol 400, polyethyleneglycol 1000, polyethyleneglycol 1500 and polyethyleneglycol 4000; the emulsifier adopts tween substances, and the tween substances includes at least one of tween-80, tween-60 and tween-40. The invention further provides the preparation method of the allicin vaginal suppository; according to the allicin vaginal suppository, the gynecological inflammation can be treated effectively, synchronously the organism immunity of patients can be enhanced, the use of drugs is improved, the administration frequency is reduced, and the use is convenient.

Description

technical field [0001] The invention relates to an allicin suppository, in particular to an anti-infection allicin vaginal suppository. [0002] The invention also relates to a preparation method of the allicin vaginal suppository. Background technique [0003] Allicin, also known as allicin, chemically called diallyl trisulfide (C6H10S3), has a variety of biological activities, such as anti-bacteria, anti-fungal, anti-pathogenic microorganisms, anti-virus, anti-tumor, anti-arrhythmia, and anti-arrhythmia. Lipid-lowering effect, improving the immune function of the body, etc. Allicin injection and capsules can inhibit amoeba, trichomonas vaginalis, bacteria, fungi and other pathogens, but injections and capsules are largely due to the concentration of the drug reaching the patient's site. Lower and affect the efficacy, but also gastrointestinal irritation, vascular mucosal irritation, and other toxic and side effects, so that the therapeutic effect is greatly reduced. Gyne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/255A61K47/42A61K47/38A61K47/34A61P15/02A61P31/04A61P31/10
Inventor 闵光宁张晓云朱劲松武新安闵光涛
Owner LANZHOU UNIVERSITY
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