Controlled-release multilayer drug-loaded artificial bone and preparation method thereof

Abstract

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

Description

technical field

[0001] The invention belongs to the field of medical materials, in particular to a drug-loaded artificial bone for surgery and a preparation method thereof. Background technique

[0002] Soft tissue injury and wound contamination in open fractures are prone to soft tissue infection or osteomyelitis, often leading to delayed union or even nonunion of fractures. Therefore, soft tissue infection and posttraumatic osteomyelitis in open fractures have always been important clinical problems. The routine treatment methods are: strict debridement, proper fixation, early closure of the wound as much as possible, and full-body application of sufficient, broad-spectrum, and potent antibiotics to prevent infection. However, long-term systemic application of antibiotics may bring about a series of side effects such as: liver and kidney damage, etc., and there are disadvantages that the drug is difficult to enter the lesion area lacking blood supply, the local drug concen...

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