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Biomedicinal gel formulation for treating alveolysis and its preparing method

A technology of periodontal disease and gel, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulations, can solve problems such as adverse reactions, and achieve the effects of improving compliance, reducing blood drug concentration, and reducing adverse reactions

Inactive Publication Date: 2006-08-09
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to maintain effective blood drug concentration and local drug concentration, oral drugs must use relatively large doses, which are likely to cause many adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Preparation of minocycline (minocycline, minocycline) gel-1

[0022] Gel components and dosage:

[0023] Minocycline 0.2g Chitosan 1.6g

[0024] Tween 80 0.23g Glycerin 2.47g

[0025] Carbomer 0.5g Distilled water 5.0g

[0026] Preparation:

[0027] (1) Stir and mix Tween 80 and glycerin at first to make a mixed solution; (2) then add minocycline to the mixed solution and mix well; (3) then prepare the mixture described in step (2). Add the mixed solution into the swollen carbomer gel and stir evenly; (4) add the amount of chitosan and stir evenly; disease biopharmaceutical gel.

[0028] Minocycline (minocycline, minocycline) is a broad-spectrum antibiotic, and its antibacterial spectrum is similar to tetracycline, but its antibacterial effect is stronger than tetracycline, and it has the characteristics of high efficiency and long-term effect. In addition, some bacteria resistant to tetracycline, such as staphylococcus and streptococcus, are effective w...

Embodiment 2

[0029] Example 2 Preparation of minocycline (minocycline, minocycline) gel-2

[0030] Gel components and dosage:

[0031] Chitosan 1.5g Distilled water 5.0g

[0032] Minocycline 0.2g Glycerin 2.40g

[0033] Tween 80 0.30g Carbomer 0.6g

[0034] Preparation:

[0035] (1) Stir and mix Tween 80 and glycerin at first to make a mixed solution; (2) then add minocycline to the mixed solution and mix well; (3) then prepare the mixture described in step (2). Add the mixed solution into the swollen carbomer gel and stir evenly; (4) add the amount of chitosan and stir evenly; disease biopharmaceutical gel.

Embodiment 3

[0036] Example 3 Preparation of Tetracycline Gel

[0037] Gel components and dosage:

[0038] Chitosan 1.4g Distilled water 5.0g

[0039] Tetracycline 0.2g Glycerin 2.45g

[0040] Tween 80 0.25g Carbomer 0.7g

[0041] Preparation:

[0042](1) First, stir and mix Tween 80 and glycerin with the stated amount to make a mixed solution; (2) then add tetracycline to the mixed solution and mix well; (3) then add the mixed solution described in step (2) (4) add the amount of chitosan, and stir evenly; (5) pack into a syringe with a conventional treatment amount to obtain the biological agent for treating periodontal disease. Drug gel.

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PUM

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Abstract

The present invention discloses a biological medicine gel preparation for curing periodontal disease and its preparation method. Said gel preparation is made up by using (by wt%) 1.5%-2.5% of tetracycline antibiotic, 14%-16% of chitosan, 5%-7% of cardralazine, 24%-26% of glycerin, 1%-3% of teen 80 and 50% of distilled water through a certain preparation process.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to a biological medicine for treating periodontal disease, in particular to a biological medicine gel preparation and a preparation method thereof for treating periodontal disease by utilizing tetracycline (Tetracycline) antibiotics / chitosan. Background technique [0002] Periodontal disease is a disease caused by inflammation of tooth supporting tissues, including gums, cementum, periodontal ligament and alveolar bone. It is one of the most common oral diseases and a cause of tooth loss. main reason. The incidence rate of periodontal disease occupies the crown of the three major diseases in stomatology (caries, periodontal disease, malocclusion), and the prevalence rate accounts for 93%. [0003] According to the oral health survey of 140,712 people aged 5-74 in 11 provinces and cities in my country, 42.6% of 12-year-old caries and 69.0% of periodontal disease were untreated; The carie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K9/00A61K47/36A61P1/02
Inventor 吉爱国汲平宋淑亮
Owner SHANDONG UNIV
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