Chinese medicine gel for treating arthritis and preparation method thereof

A gel and arthritic technology, applied in the field of traditional Chinese medicine gel for treating arthritis and its preparation field, can solve the problems of achieving effective blood drug concentration, difficult to control the dosage, affecting the curative effect of the drug, etc., and avoid gastrointestinal irritation. , reduce the number of doses, reduce the effect of toxic side effects

Inactive Publication Date: 2009-07-01
SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral preparations of traditional Chinese medicine often contain highly toxic drugs such as Aconitum Aconiti, Araceae, and Nuxyche, and the dose is difficult to control. From the perspective of biopharmaceuticals, it is difficult to achieve effective blood drug concentration in the lesion, which affects the efficacy of the drug.
[0004] The theory of "external treatment of internal diseases" in traditional Chinese medicine has a long history and has accumulated a large number of good and proven prescriptions. However, traditional Chinese medicine for external treatment generally has disadvantages such as backward dosage forms, large doses, and inconvenient use. Traditional Chinese medicine preparations for external use have become an important topic in the modernization of traditional Chinese medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Grind raw Aconitum aconitum into the coarsest powder, use 70% acidic ethanol pH=3 to extract by percolation, collect 8 times the amount of percolation liquid, depressurize the percolation liquid to recover ethanol, concentrate water to a relative density of 1.05-1.07, 60 Heat measurement at ℃, filter, adjust the pH value of the filtrate to 9-10 with ammonia water, extract 5 times with chloroform until there is no alkaloid reaction, combine the extracts, recover chloroform, and obtain a clear paste, dry under reduced pressure at 60°C to obtain Shengchuan Aconitum Extract.

[0016] Swell 1g of Carbopol 940 with water, add 1.5g of Aconitum aconitum extract; dissolve 0.1g of camphor in 70% ethanol, and add 0.04g of artificial musk in ether; then add 10ml of propylene glycol, 1.5g of triethanolamine, 5ml of glycerin, Disodium edetate 0.05g, add distilled water to 100g, stir evenly to form a gel.

Embodiment 2

[0018] Grind raw Aconitum aconitum into the coarsest powder, use 70% acidic ethanol pH=3 to extract by percolation, collect 8 times the amount of percolation liquid, depressurize the percolation liquid to recover ethanol, concentrate water to a relative density of 1.05-1.07, 60 Heat measurement at ℃, filter, adjust the pH value of the filtrate to 9-10 with ammonia water, extract 5 times with chloroform until there is no alkaloid reaction, combine the extracts, recover chloroform, and obtain a clear paste, dry under reduced pressure at 60°C to obtain Shengchuan Aconitum Extract.

[0019] Add 1.5g of hypromellose to 50 times of distilled water to fully swell, add Aconitum aconitum extract, 1.5g of Dajinhua extract, 0.1g of camphor, 0.04g of musk, 1.5g of glycerin, 5ml of azone, 15ml of propylene glycol, Ethylparaben 0.1g, add distilled water to 100g, stir evenly to form a gel.

Embodiment 3

[0021] Grind raw Aconitum aconitum into the coarsest powder, use 70% acidic ethanol pH=3 to extract by percolation, collect 8 times the amount of percolation liquid, depressurize the percolation liquid to recover ethanol, concentrate water to a relative density of 1.05-1.07, 60 Heat measurement at ℃, filter, adjust the pH value of the filtrate to 9-10 with ammonia water, extract 5 times with chloroform until there is no alkaloid reaction, combine the extracts, recover chloroform, and obtain a clear paste, dry under reduced pressure at 60°C to obtain Shengchuan Aconitum Extract.

[0022] Add 0.04g of polyvinylpyrrolidone to 50 times of distilled water to fully swell, add 1.5g of Aconitum aconitum extract, 0.1g of camphor, 0.04g of musk, 12ml of glycerin, 0.05g of benzalkonium bromide, and add distilled water to 100g according to the above ratio , Stir evenly to form a gel.

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Abstract

The invention relates to a traditional Chinese medicine gel for treating arthritis and preparation method thereof, belonging to medical field. The gel is composed of raw sihcuan axonite root extract and pharmaceutical adjuvant by the following weight ratio: raw sihcuan axonite root extract 1.5%, camphor 0.1%, musk 0.04%, high molecular matrix material 0.1-5%, humectant 5-15%, preservatives 0-0.5%, solvent 50-80%.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a traditional Chinese medicine gel for treating arthritis and a preparation method thereof. Background technique [0002] Arthritis is a clinically common and frequently occurring intractable disease, which belongs to the category of arthralgia in traditional Chinese medicine. Special epidemiological surveys show that the incidence of this disease among middle-aged and elderly people in my country is as high as 70%, among which the incidence of cervical spine, lumbar spine and knee joint is the highest, and the three together account for more than 90% of bone and joint diseases. In an aging society, this problem is even more prominent. [0003] In the existing methods for the treatment of arthritis, Western medicine often adopts oral non-steroidal antipyretic analgesics or surgical treatments such as "traction". Oral drugs have many side effects; surgical treatment has a long c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/00A61K47/10A61K47/16A61K47/14A61K47/22A61K47/32A61K47/38A61P19/02A61K31/125A61K35/55
Inventor 王勇
Owner SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION
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