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Preparation method of no-alcohol type Shexiang Qushu liquid oral preparation

A technology of Huoxiang and Patchouli, which is applied in the preparation field of Huoxiang Qushu water preparation, can solve the problems of limited range of treatment objects, large irritation, skin flushing, etc., to avoid gastrointestinal irritation, reduce irritation, relieve The effect of discomfort

Inactive Publication Date: 2009-03-11
SINOMEDICINE BEIJING PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, for people who are allergic to alcohol, they will have an allergic reaction after taking it, with fever, rapid heartbeat, skin flushing, granular papules, itching, etc., and sometimes even heart palpitations, shortness of breath, irritability, and lower blood pressure. Due to the high content of alcohol, even patients who are not allergic to alcohol will irritate their gastrointestinal tract after taking it, often feel uncomfortable after taking it, and even cause vomiting, so it is not easy for patients to accept, which affects the normal performance of the curative effect
The elderly, children, and patients who are prohibited from drinking alcohol such as fever, vomiting, and gastrointestinal ulcers are also unsuitable for taking it, which limits the scope of treatment objects.
Secondly, due to the relatively large amount of ethanol used in the production process, and the final formulation also contains a higher content of ethanol, thus increasing the economic cost

Method used

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  • Preparation method of no-alcohol type Shexiang Qushu liquid oral preparation
  • Preparation method of no-alcohol type Shexiang Qushu liquid oral preparation
  • Preparation method of no-alcohol type Shexiang Qushu liquid oral preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] According to the raw materials and dosage ratio specified in the twentieth volume of "Huoxiang Qushu Shui" of the Ministry of Health Drug Standards for Chinese Medicine Prescriptions, take 400g of Patchouli, 150g of Elsholtzia, 100g of Angelica dahurica, 100g of Perilla Leaf, 200g of Atractylodes Rhizome, and 75g of Clove , 200g tangerine peel, 200g big belly peel, 200g Pinellia ternata 200g, Poria 200g, 100g ginger, 100g licorice, all crude drugs are purified and crushed. First add patchouli, elm, angelica, perilla leaves, atractylodes, cloves, tangerine peel, ginger to 8 times the amount of water, let stand for 1 hour, measure the water absorption, and then add water to make up (so that the water is still the weight of the dry medicinal material 8 times), use steam distillation to extract the volatile oil, until the amount of oil in the collection bottle no longer increases, stop heating and cooling, transfer the volatile oil and aromatic water to the container, add an ap...

Embodiment 2

[0056]According to the raw materials and dosage ratio specified in the twentieth volume of "Huoxiang Qushu Shui" in the Ministry of Health Drug Standards, take 200g of Patchouli, 75g of Elsholtzia, 50g of Angelica dahurica, 50g of Perilla Leaf, 100g of Atractylodes Rhizome, and Clove 37.5 g. Tangerine peel 100g, big belly peel 100g, Pinellia ternata 100g, Poria 100g, ginger 50g, licorice 50g, each crude drug raw material is purified and crushed. First add patchouli, Elsholtzia, Angelica dahurica, perilla leaves, atractylodes, cloves, tangerine peel, ginger to 10 times the amount of water, soak for 2 hours, measure the water absorption, add water to make up, steam distillation to extract the volatile oil, the volatile oil and Move the aromatic water to the container, add an appropriate amount of Tween 80, mix well, and set aside; filter the distilled aqueous solution and concentrate to a clear cream with a relative density of 1.10 to 1.20 (50°C) for use. After extracting the volati...

Embodiment 3

[0058] The raw materials and dosage are the same as in Example 2. After purification and crushing of each API, patchouli, Elsholtzia, Angelica dahurica, perilla leaves, atractylodes, clove, tangerine peel, ginger add 10 times the amount of water, let stand for 3 hours, measure the water absorption, and then add water to make up. Use steam distillation to extract the volatile oil, transfer the volatile oil and aromatic water to a container, add an appropriate amount of Tween 80, mix well, and set aside. The distilled aqueous solution is filtered and concentrated to a clear paste with a relative density of 1.10 to 1.20 (50°C) for use. After extracting the volatile oil, the patchouli and other medicinal residues are combined with the remaining four flavors such as the belly skin, and extracted with 80% ethanol for 3 times, 2 hours each time, the reflux liquid is combined, filtered, and the ethanol is recovered under reduced pressure and concentrated to a relative density It is 1.10~1...

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Abstract

The invention relates to a preparation method of a nonalcoholic ageratum summer-heat clearing liquid oral preparation. The raw materials are chosen according to the raw materials which are specified by 'ageratum summer-heat clearing water' recorded by ministerial traditional Chinese medicine standard and the dosage proportion thereof. The particular method of the invention is as follows: patchouly, elsholtzia haichowensis, angelica dahurica, perilla leaf, rhizoma atractylodis, clove, dried orange peel, shell of areca nut, rhizoma pinellinae praeparata, tuckahoe, ginger and liquorice are chosen; firstly, the patchouly, the elsholtzia haichowensis, the angelica dahurica, the perilla leaf, the rhizoma atractylodis, the clove, the dried orange peel and the ginger which contain volatile oil are extracted to obtain the volatile oil; solubilizer is added into distilment to lead the volatile oil and aromatic water to be well blended; the water part is steamed with water, and clear paste is remained; the residue after the volatile oil is extracted, shell of areca nut, rhizoma pinellinae praeparata, tuckahoe, and liquorice are extracted by ethanol; after the ethanol is volatilized, the two clear pastes are combined and are blended with the volatile oil; finally flavouring agent and specified amount of water are added to prepare nonalcoholic ageratum summer-heat clearing liquid oral preparation. Compared with ageratum summer-heat clearing liquid which contains 40-45% of ethanol recorded by ministered standard, the invention does not contain ethanol, thus avoiding the side effect such as irritating gastrointestinal tract and the like, being accepted by patients easily, better taking the healing effect, expanding the scope of treated subjects. In addition, compared with the original ageratum summer-heat clearing water, the amount of the ethanol is reduced in the course of production, and the cost is reduced.

Description

Technical field [0001] The invention relates to a non-alcoholic liquid oral preparation prepared from traditional Chinese medicine plant extracts, in particular to a preparation method of a Huoxiang Qushushui (non-alcoholic) preparation. Background technique [0002] Huoxiang Qushu Shui, its standard is derived from the 20th volume of the Ministry of Health Pharmaceutical Standards Chinese Medicine Prescriptions, and its prescription consists of patchouli, elm, angelica, perilla leaves, atractylodes, clove, tangerine peel, pot belly peel, French half It is composed of summer, tuckahoe, ginger, and licorice, and its preparation is an oral preparation with a higher alcohol content. Its functions are mainly treating heat and dampness, relieving the surface and neutralizing the body. It is used to accumulate dampness, fever, headache, no sweat, lazy limbs, nausea and vomiting, abdominal pain and diarrhea caused by heat and cold. [0003] Patchouli is the above-ground part of Pogostem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/08A61P1/12A61P43/00
Inventor 王立峰田元子
Owner SINOMEDICINE BEIJING PHARMA SCI
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