Preparation method of temperature sensitivity chitosan derivate-hydroxybutyl chitosan

A technology of chitosan derivatives and hydroxybutyl chitosan, which is applied in the preparation of hydroxybutyl chitosan and the preparation of temperature-sensitive chitosan derivatives-hydroxybutyl chitosan, can solve mechanical problems Poor performance, slow response speed, and limited application of hydrogels, etc., to achieve good water solubility

Active Publication Date: 2008-10-15
SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the unique responsiveness of intelligent hydrogel, it has good application prospects in chemical converters, memory element switches, sensors, artificial muscles, chemical memory, molecular separation systems, tissue engineering, drug carriers, etc. However, due to the disadvantages of traditional hydrogels, such as poor mechanical properties and slow response speed, the application of hydrogels is greatly limited.

Method used

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  • Preparation method of temperature sensitivity chitosan derivate-hydroxybutyl chitosan
  • Preparation method of temperature sensitivity chitosan derivate-hydroxybutyl chitosan
  • Preparation method of temperature sensitivity chitosan derivate-hydroxybutyl chitosan

Examples

Experimental program
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Effect test

Embodiment 1

[0023] A kind of preparation method of thermosensitive chitosan derivative-hydroxybutyl chitosan is:

[0024] The first step. the preparation of chitosan:

[0025] Preparation of chitosan solution: take 100 grams of fresh shrimp shells, remove the head, feet and tail, wash with water, soak in 5% hydrochloric acid with 800 ml concentration to remove calcium, and soak with 800 ml concentration of 10% sodium hydroxide to remove the chitosan solution. Miscellaneous protein, washed with water for injection to pH 7-8, dried, and ground to obtain powdered chitin, and then deacetylated in 800 ml of 50% sodium hydroxide solution at a temperature of 80°C-100°C for 18- For 24 hours, wash the pH value with water for injection to 7-8, dehydrate with 95% alcohol, and finally vacuum-dry to obtain chitosan with a deacetylation degree of 85-95%;

[0026] The second step. the purification of chitosan, remove residual protein and pigment in chitosan:

[0027] Add the chitosan prepared in the f...

Embodiment 2

[0034] The preparation of embodiment 2 hydroxybutyl chitosan of the present invention

[0035] The preparation of the first step chitosan is with embodiment 1;

[0036] The purification of second step chitosan is with embodiment 1;

[0037] The alkalization of the third step chitosan is with embodiment 1;

[0038] Step 4. Hydroxybutylation of Chitosan

[0039]Filter and extrude the excess lye in 10 grams of alkalized chitosan with 100-mesh silk cloth, transfer it to a three-necked bottle, add 80 ml of isopropanol and stir for 2 hours to completely disperse the chitosan, then separate the liquids Slowly add 100 ml of 1,2-epoxybutane dropwise into the funnel, and react at room temperature for 5 days. After the reaction is complete, 9 times the volume of acetone is precipitated, washed to a pH value of 7-8, and vacuum-dried at 50°C to obtain a white powder.

Embodiment 3

[0040] The preparation of embodiment 3 hydroxybutyl chitosan of the present invention

[0041] The preparation of the first step chitosan is with embodiment 1;

[0042] The purification of second step chitosan is with embodiment 1;

[0043] The alkalization of the third step chitosan is with embodiment 1;

[0044] Step 4. Hydroxybutylation of Chitosan

[0045] Filter and extrude excess lye in 10 grams of alkalized chitosan with 100 mesh silk cloth, transfer to a three-necked bottle, add 80 milliliters of isopropanol and stir for 1-2 hours to disperse chitosan completely, then Slowly add 200 ml of 1,2-epoxybutane dropwise into the separatory funnel, and react at room temperature for 4 days. After the reaction is complete, 9 times the volume of acetone precipitates, washes the pH value to 7-8, and vacuum-dries at 50°C to obtain a white powder .

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Abstract

The invention relates to a method for making a chitosan derivative. The method is characterized in that: firstly, the purified chitosan is activated by a strong base to form a hydroxyl-K type chitosan; secondly, a 1, 2-butyl oxide linkage is taken as an etherifying agent, an isopropanol is taken as a disperse phase, the reaction lasts 2 to 4 days moderately at room temperature; after the reaction is finished, 8 to 10 times volume of acetone is precipitated and washed to be neutral as well as is dried in vacuum at a temperature of 50 DEG C to obtain the white powder. The hydroxybutyl chitosan with different degrees of substitution is obtained by controlling the proportion of the chitosan and the 1, 2-butyl oxide linkage and the reaction time. The method has the advantages of good water-solubility and the existence of the temperature sensitivity at a physiological temperature.

Description

technical field [0001] The invention relates to a preparation method of a thermosensitive chitosan derivative-hydroxybutyl chitosan, in particular to a preparation method of a thermosensitive hydroxybutyl chitosan with good water solubility, which can be used in chemical The field of converter, memory element switch, sensor, artificial muscle, chemical memory, molecular separation system, tissue engineering, and drug carrier belongs to the field of biotechnology. Background technique [0002] Chitosan [Chitosan, (1,4)-2-amino-2-deoxy-β-D-glucan] is a high-molecular-weight homopolysaccharide obtained through partial deacetylation of chitin and is a The only alkaline polysaccharide that exists in large quantities in The annual biosynthesis of chitin in the biological world is estimated to be as many as tens of tons, far exceeding other amino polysaccharides, and it is an inexhaustible renewable resource. In the middle and late last century, the international community attach...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 魏长征顾其胜侯春林
Owner SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD
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