Method for preparing antibacterial film of quaternarized chitosan iodine complex

Abstract

The invention relates to a method for preparing an antibacterial film of a quaternarized chitosan iodine complex. The method comprises the following steps: inserting quaternary ammonium salt on the hydroxyl group or amino group of a chitosan structure unit to prepare a quaternarized chitosan derivative; soaking a blend film of the quaternarized chitosan derivative and gelatin or poval into a simple substance iodine solution for 4-6 hours to obtain the antibacterial film of the quaternarized chitosan / gelatin or poval iodine complex, or directly preparing a quaternary ammonium salt chitosan iodine complex from the quaternarized chitosan derivative and simple substance iodine, and then mixing the quaternary ammonium salt chitosan iodine complex with gelatin or poval to prepare the blend antibacterial film containing iodine. By using the method, the water solubility and the biological activity of chitosan can be improved; simple substance iodine is stabilized and complexed by utilizing the affinity of a quaternary ammonium salt group and an iodine molecule; according to the different positions of a human body, the prepared antibacterial film can be compounded with other materials; a chitosan base has hemostasis, antiphlogosis and tissue repair functions on human body wound, can reduce the stimulation of iodine on the wound and controls the release of iodine, and the double effects of the chitosan base and iodine provide an ideal curing environment for a wound surface.

Description

technical field

[0001] The invention relates to the quaternization modification of chitosan, a natural macromolecule material, to prepare corresponding antibacterial and anti-inflammatory medical films complexed with iodine. The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing an antibacterial film of quaternized chitosan complexed with iodine. Background technique

[0002] Chitosan has the functions of antibacterial and anti-inflammatory, hemostasis, analgesia and promoting the growth of body tissue. The film made of chitosan polymer can be used as a good wound covering material. At the same time, it can also be made into artificial skin, which is used for wound protection of burns, skin grafting, and skin incision, and the effect is better than non-injury cloth made of cellulose. At present, the production technology of medical dressings in my country is relatively low, and the added value of products is not high,...