Method for preparing antibacterial film of quaternarized chitosan iodine complex

A technology of quaternized chitosan and complexed iodine is applied in the preparation of antibacterial films of quaternized chitosan complexed with iodine, anti-inflammatory medical films, and antibacterial fields, and can solve the problems of insignificant antibacterial effect, large wound irritation, iodine stability and other issues, to achieve the effects of good hand feel, anti-inflammatory wound healing, and improved mechanics and air permeability

Inactive Publication Date: 2012-07-25
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to control the dosage of cream, and it is more irritating to the wound surface
Therefore, how to make better use of iodine in biomedicine has two main problems: one is the stability of iodine in the compound of iodine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 1 part of chitosan (viscosity average molecular weight range of 30,000 to 300,000) and dissolve it in 3% to 5% acetic acid or hydrochloric acid solution, and add 30% to 50% volume ratio of absolute ethanol to dilute. Add glutaraldehyde or benzaldehyde 3 to 6 times the mass of chitosan at room temperature and stir for 3 to 6 hours to obtain a uniform milky white liquid. Add 5 mol / L sodium hydroxide solution to the above emulsion, stir until a white flocculent precipitate is produced, stand and filter to obtain a white solid, extract with absolute ethanol in a Soxhlet extractor for 24 hours, and dry under vacuum at 40-60°C to obtain chitosan Aldehyde Schiff base. Swell chitosan aldehyde Schiff base in pyridine / chloroform mixed solvent for 8-12 hours, add quaternary ammonium salt monomer (diethylaminochloroethane hydrochloride, Trichlorodihydroxypropyltrimethylammonium chloride), stirred and reacted for 12-24 hours, and the solid product obtained by filtration was su...

Embodiment 2

[0035] Take 1 part of chitosan (viscosity average molecular weight range of 30,000 to 300,000) and put it into ethanol / isopropanol mixed solvent to swell for 2 to 4 hours. The mass ratio of chitosan to sodium hydroxide is 1:0.1 to 1:0.3. Add 5.0mol / L sodium hydroxide solution to alkalinize for 2-4 hours. After the system is heated up to 50-70° C., quaternary ammonium salt monomers (diethylaminochloroethane hydrochloride, trichlorodihydroxypropyltrimethylammonium chloride) that are 3 to 6 times the mass of chitosan are added. Stir for 3-6 hours to discharge the slurry, adjust the pH to 7.0 with hydrochloric acid with a mass fraction of 10%, let it stand still, and filter with suction to obtain a solid crude product. The crude product was extracted with absolute ethanol on a Soxhlet extractor for 8 to 12 hours, and dried in vacuum at 40 to 60°C to obtain quaternary ammonium chitosan derivatives (AST -CTS).

Embodiment 3

[0037] 1 part of elemental iodine is dissolved in a potassium iodide solution with a mass ratio of 0.9:1, and the pH value is adjusted between 4 and 5 with 3% to 5% acetic acid. Add 5 to 8 times the total volume of isopropanol / tert-butanol mixed solvent, add hexadecyltrimethylammonium chloride with a mass ratio of 1:0.1 to 1:0.3 with elemental iodine, and use 800 to 1000r / Emulsify and stir at a speed of min for 1-2 hours to disperse the surfactant and iodine evenly. Weigh the quaternized grafted chitosan derivative (AS-CTS) in an amount of 4:1 with the elemental iodine mass ratio, add it into the above dispersion system, emulsify and stir at a speed of 800-1000r / min for 3-6h , the compound of quaternized chitosan complexed with iodine is obtained, which is a uniform solution, wherein the mass fraction of elemental iodine is about 4.5% to 5.5%. The complex of quaternized chitosan complexed with iodine is denoted as AS-CTS-I 2 .

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Abstract

The invention relates to a method for preparing an antibacterial film of a quaternarized chitosan iodine complex. The method comprises the following steps: inserting quaternary ammonium salt on the hydroxyl group or amino group of a chitosan structure unit to prepare a quaternarized chitosan derivative; soaking a blend film of the quaternarized chitosan derivative and gelatin or poval into a simple substance iodine solution for 4-6 hours to obtain the antibacterial film of the quaternarized chitosan/gelatin or poval iodine complex, or directly preparing a quaternary ammonium salt chitosan iodine complex from the quaternarized chitosan derivative and simple substance iodine, and then mixing the quaternary ammonium salt chitosan iodine complex with gelatin or poval to prepare the blend antibacterial film containing iodine. By using the method, the water solubility and the biological activity of chitosan can be improved; simple substance iodine is stabilized and complexed by utilizing the affinity of a quaternary ammonium salt group and an iodine molecule; according to the different positions of a human body, the prepared antibacterial film can be compounded with other materials; a chitosan base has hemostasis, antiphlogosis and tissue repair functions on human body wound, can reduce the stimulation of iodine on the wound and controls the release of iodine, and the double effects of the chitosan base and iodine provide an ideal curing environment for a wound surface.

Description

technical field [0001] The invention relates to the quaternization modification of chitosan, a natural macromolecule material, to prepare corresponding antibacterial and anti-inflammatory medical films complexed with iodine. The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing an antibacterial film of quaternized chitosan complexed with iodine. Background technique [0002] Chitosan has the functions of antibacterial and anti-inflammatory, hemostasis, analgesia and promoting the growth of body tissue. The film made of chitosan polymer can be used as a good wound covering material. At the same time, it can also be made into artificial skin, which is used for wound protection of burns, skin grafting, and skin incision, and the effect is better than non-injury cloth made of cellulose. At present, the production technology of medical dressings in my country is relatively low, and the added value of products is not high,...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08J5/18C08L5/08C08L89/00C08L29/04C08K3/02C08B37/08
Inventor 丁德润
Owner SHANGHAI UNIV OF ENG SCI
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