40 results about "Silver tetrafluoroborate" patented technology

Methods for separating di-olefins from mono-olefins, and olefins from non-olefins such as paraffins, oxygenates and aromatics; are provided. The methods use metal salts which complex both mono-olefins and di-olefins, but which selectively complex di-olefins in the presence of mono-olefins. The metal salts are dissolved or suspended in ionic liquids, which tend to have virtually no vapor pressure. Preferred salts are Group IB salts, more preferably silver and copper salts. A preferred silver salt is silver tetrafluoroborate. A preferred copper salt is silver CuOTf. Preferred ionic liquids are those which form stable solutions, suspensions or dispersions of the metal salts, which do not dissolve unwanted non-olefins, and which do not isomerize the mono- or di-olefins. The equivalents of the metal salt can be adjusted so that di-olefins are selectively adsorbed from mixtures of mono- and di-olefins. Alternatively, both mono- and di-olefins can be adsorbed, and the mono-olefins selectively desorbed. The latter approach can be preferred when non-olefins are also to be separated. The mono- and di-olefin-containing mixture can be in the gas phase or in the liquid phase. The flow of mono- and di-olefin-containing mixture over / through the ionic liquid can be, for example, co-current, counter-current, or staged in stirred tanks, with countercurrent being preferred.

The invention discloses a preparation method of antibacterial polyester fabrics and belongs to the technical field of textile materials. The preparation method comprises the following steps: after sequentially carrying out continuous modification treatment on polyester fabric original samples including clothing, tablecloth and curtains by virtue of a Na2CO3 solution, a mixed solution of alizarin red and sodium cyclamate, a mixed solution of aniline, hydrochloride and ammonium persulfate, a mixed solution of DL-mercaptosuccinic acid and D-penicillamine and a nano-silver solution, putting the treated polyester fabric original samples into a silver tetrafluoroborate aqueous solution, carrying out reaction at room temperature for 30 minutes, washing the product by a great deal of water, and drying at the temperature of 40 DEG C to obtain the antibacterial polyester fabrics. The antibacterial polyester fabrics prepared by the preparation method have the broad-spectrum antibacterial property, are good in antibacterial effect particularly on staphylococcus aureus, bacillus subtilis, Escherichia coli and pseudomonas aeruginosa, are strong in persistence and have the single-strain inhibitory rate reaching 95-99.7 percent after being washed for 30 times.

The invention discloses a preparation method of vinorelbine. The method comprises the following steps: taking anhydrovinblastine as a raw material; performing a bromination reaction to prepare bromide; and then performing separation by alumina column chromatography. The bromide is condensed and cyclized to vinorelbine during a column chromatographic separation process without using silver tetrafluoroborate and tetrahydrofuran, and product purity can be up to 65% (HPLC). The method helps avoid using the expensive silver tetrafluoroborate reagent, shorten process flow, lower raw material cost and reduce environmental pollution; meanwhile, the method also helps solve the disadvantages of unstable product quality, yield and the like in a silver tetrafluoroborate process and has good popularization and application prospect.

The invention discloses cyanide-free silver electroplating liquid, and belongs to the field of cyanide-free silver electroplating. The cyanide-free silver electroplating liquid is prepared by the following raw materials: 10-60 g / L of silver tetrafluoroborate, 0.1-1.5 g / L of methylpentynol, 0.1-1.2 g / L of 1, 4 butynediol, 10-20 g / L of ammonium acetate, 7-20 g / L of anisaldehyde, and 10-25 g / L of benzoic acid, wherein the pH value of the cyanide-free silver electroplating liquid is 3-7. The cyanide-free silver electroplating liquid contains no cyanide ions, reduces the harm of wastes to the environment and operators, is simple in preparation, and is easy to operate. The stable electroplating liquid can be obtained; the plating layer stress is low; and the bonding force is tighter.

Various processes are disclosed for preparing protected epicatechin oligomers having (4β,8)-interflavan linkages. In one process, a tetra-O-protected epicatechin monomer or oligomer is coupled with a protected, C-4 activated epicatechin monomer in the presence of an acidic clay such as a mortmorillonite clay. In another process, a 5,7,3′,4′-benzyl protected or a 3-acetyl-, 5,7,3′,4′-benzyl protected epicatechin or catechin monomer or oligomer is reacted with 3-O-acetyl-4-[(2-benzothiazolyl)thio]-5,7,3′,4′-tetra-O-benzylepicatechin in the presence of silver tetrafluoroborate. In another process, two 5,7,3′,4′-benzyl protected epicatechin monomers activated with 2-(benzothiazolyl)thio groups at the C-4 positions are cross-coupled in the presence of silver tetrofluoroborate. A process is also disclosed for reacting an unprotected epicatechin or catechin monomer with 4-(benzylthio)epicatechin or catechin. The use of naturally-derived and synthetically-prepared procyanidin (4β,8)4-pentamers to treat cancer is also disclosed.

The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.

Various processes are disclosed for preparing procyanidin oligomers having (4,8)-interflavan linkages. In an improved process, a tetra-O-protected-epicatechin or catechin monomer or oligomer is coupled with a protected, C-4 alkoxy-activated-epicatechin or -catechin monomer in the presence of an acidic clay instead of a Lewis acid. In a second process, a 5,7,3′,4′-tetra-O-protected or preferably penta-O-protected-epicatechin or -catechin monomer or oligomer is reacted with a tetra-O-protected or preferably penta-O-protected-epicatechin or -catechin monomer having a thio activating group at the C-4 position; the coupling is carried out in the presence of silver tetrafluoroborate. In third process, two molecules of a penta-O-protected-epicatechin or -catechin monomer activated with a 2-(benzothiazolyl)thio group at the C-4 position are self-condensed in the presence of silver tetrafluoroborate. An improved two-step process for preparing a C-4 alkoxy activated tetra-O-benzyl-protected, 8-bromo-blocked-epicatechin or -catechin monomer is also provided. The use of naturally-derived and synthetically-prepared procyanidin (4β,8)4-pentamers to treat cancer is also disclosed.

A production method of high purity silver tetrafluoroborate, capable of producing silver tetrafluoroborate (AgBF4) at purity higher than the conventional, without using an organic solvent. The production method of the present invention is characterized in that the method comprises the step of: reacting silver fluoride with boron trifluoride in the presence of anhydrous hydrofluoric acid. Boron trifluoride is delivered into a solution obtained by dissolving or suspending silver fluoride in an anhydrous hydrofluoric acid solution.

The invention relates to a preparation method of silver tetrafluoroborate, which comprises the steps of mixing and reacting a fluoboric acid source and silver salt in a reaction medium to obtain the silver tetrafluoroborate, wherein the fluoboric acid source is selected from at least one of tetrafluoroborate and tetrafluoroboric acid; and the reaction medium is a mixed solvent of a first organic solvent and water or water, and the first organic solvent is selected from at least one of diethyl ether, nitromethane and methylbenzene. The preparation method is wide in raw material applicability, the raw materials are low in toxicity and easy to obtain, the problem that the toxicity is too high when silver fluoride and boron trifluoride serve as reaction raw materials is solved, the reaction can be carried out at the room temperature, the reaction condition is mild, the reaction is easy to operate, the needed time is short, the requirement for equipment is low, and the production safety problem is guaranteed.

The invention belongs to the technical field of precious metal preparation, and relates to a method for preparing bis(norbornadiene)rhodium tetrafluoroborate. A red bis(norbornadiene)rhodium tetrafluoroborate solid is obtained by subjecting rhodium trichloride hydrate and norbornadiene serving as raw materials to an ion exchange reaction with silver tetrafluoroborate in an inert gas protection environment and carrying out filter pressing. The preparation method is simple, the yield and the purity of a bis(norbornadiene)rhodium product are improved, and production cost is reduced.

The invention provides a method for efficiently and highly selectively synthesizing diarylmethylphosphonate derivatives containing different substituted functional groups. According to the method, silver tetrafluoroborate is used as a catalyst, trialkyl phosphite and a 4-arylmethylene-2,6-di-tert-butyl-2,5-cyclohexadien-1-one compound are used as reaction substrates, and an organic solvent is added into a reaction system. The method has the advantages that the catalyst is cheap and easily available; substrate applicability is high; reaction conditions are mild, safe and reliable; the selectivity of the obtained target products is close to 100%; and the yield of the target products is as high as 90% or above. The method overcomes the defects of poor reaction selectivity, complex reaction steps, low yield, need for reagents harmful to the environment and the like in traditional synthesis of diarylmethyl substituted phosphonate derivatives, and has favorable industrial application prospects. The invention also provides the corresponding diarylmethyl substituted phosphonate derivatives containing different substituted functional groups at the same time.

The invention discloses a 3,3-disubstituted indolinone and its derivative, and a synthesis method thereof. The product is obtained through a one-step three-component reaction of a diazo compound, a substituted benzyl alcohol and (propargyl alcohol)hexacarbonyldicobalt, which are used as raw materials, in an organic solvent with rhodium acetate and silver tetrafluoroborate as a catalyst at a high selectivity and a high yield. The method has the advantages of good selectivity, mild reaction conditions, high yield, and simplicity and safety in operation. The indolinone framework of the 3,3-disubstituted indolinone and its derivative is an important structural fragment for many bioactive complex natural products and medicine molecules, and the eneyne structure in the above compounds is also animportant intermediate and reaction building block in the synthesis of many medicine molecules, so the compounds can be used as important intermediates for medicines and chemical industry, and have abroad application prospect in the field of medicinal fields.

The invention discloses a preparation method of antibacterial polyester fabrics and belongs to the technical field of textile materials. The preparation method comprises the following steps: after sequentially carrying out continuous modification treatment on polyester fabric original samples including clothing, tablecloth and curtains by virtue of a Na2CO3 solution, a mixed solution of alizarin red and sodium cyclamate, a mixed solution of aniline, hydrochloride and ammonium persulfate, a mixed solution of DL-mercaptosuccinic acid and D-penicillamine and a nano-silver solution, putting the treated polyester fabric original samples into a silver tetrafluoroborate aqueous solution, carrying out reaction at room temperature for 30 minutes, washing the product by a great deal of water, and drying at the temperature of 40 DEG C to obtain the antibacterial polyester fabrics. The antibacterial polyester fabrics prepared by the preparation method have the broad-spectrum antibacterial property, are good in antibacterial effect particularly on staphylococcus aureus, bacillus subtilis, Escherichia coli and pseudomonas aeruginosa, are strong in persistence and have the single-strain inhibitory rate reaching 95-99.7 percent after being washed for 30 times.

The invention discloses a preparation method of vinorelbine tartrate, which comprises the following steps: 1) preparation of dehydrated vinblastine: taking vinblastine sulfate and vindoline as initialraw materials, and carrying out ferric trichloride catalysis and sodium borohydride reduction to obtain dehydrated vinblastine; 2) preparation of bromo-dehydrated vinblastine: carrying out bromination reaction on dehydrated vinblastine and N-bromo-succinimide to obtain a bromo-dehydrated vinblastine crude product; carrying out column purification on the bromo-dehydrated vinblastine crude productto improve the purity of the bromo-dehydrated vinblastine crude product so as to obtain bromo-dehydrated vinblastine; 3) preparation of vinorelbine: carrying out debromination rearrangement on bromo-dehydrated vinblastine and a silver tetrafluoroborate aqueous solution to obtain a vinorelbine crude product; and recrystallizing the vinorelbine crude product to obtain a vinorelbine pure product; and4) preparation of vinorelbine tartrate: carrying out a salt forming reaction on the pure vinorelbine tartrate and tartaric acid to obtain vinorelbine tartrate. The method has the advantages of simpleoperation, few side reactions, great increase of the purity and the yield, reduction of the production cost, and suitableness for large-scale production.

A production method of high purity silver tetrafluoroborate, capable of producing silver tetrafluoroborate (AgBF4) at purity higher than the conventional, without using an organic solvent. The production method of the present invention is characterized in that the method comprises the step of: reacting silver fluoride with boron trifluoride in the presence of anhydrous hydrofluoric acid. Boron trifluoride is delivered into a solution obtained by dissolving or suspending silver fluoride in an anhydrous hydrofluoric acid solution.

The invention provides a tricyclohexylphosphine-5-fluorouracil-1-acetic acid mononuclear silver coordination compound, a preparation method and application thereof, and belongs to the technical field of silver compounds. The mononuclear silver coordination compound is prepared by taking 5-fluorouracil-1-yl acetic acid, silver tetrafluoroborate and tricyclohexylphosphine as raw materials and reacting in the presence of triethylamine. According to the invention, one unit cell of the compound contains two same asymmetric structural units, and a central metal silver ion is respectively coordinated with a phosphorus atom in tricyclohexylphosphine and a 5-fluorouracil-1-yl acetic acid anion; researches show that the interaction mode of the mononuclear silver coordination compound and CT-DNA is an electrostatic mode, and the binding constant K of the mononuclear silver coordination compound and calf thymus DNA is 3.03*10<3> L / mol, so that the cytotoxicity is greatly reduced; and an anti-cancer activity experiment shows that the anti-cancer effect of the mononuclear silver coordination compound on MDA-MB-231 and HCT116 is remarkably enhanced compared with that of 5-fluorouracil, and particularly, the effect is better after infrared irradiation.

The invention relates to a silver nanowire and a preparation method and application thereof. The preparation method of the silver nanowire comprises the following steps that silver salt is dissolved in a first solvent, a first mixture is obtained, the silver salt is selected from at least one of silver trifluoromethanesulfonate, silver diethyl dithiocarbamate and succinimide silver salt, and the first solvent is water; a seed crystal, a reducing agent and a dispersing agent are dissolved in a second solvent at the temperature of 48-72 DEG C, a second mixture is obtained, the seed crystal is selected from at least one of tri-silver citrate or silver tetrafluoroborate, and the second solvent is water; and the first mixture and the second mixture are mixed in a dropwise adding manner, the pHis adjusted to 8-8.5, solid-liquid separation is carried out, and the silver nanowire is obtained. By means of the preparation method, the silver nanowire with the good bending resistance and the longlength-diameter ratio can be obtained.

The present invention provides a kind of synthetic method that under the action of monovalent silver and reducing agent, the tryptamine alkyne amide substrate containing indole can generate hydrogenated pyridine spiroindoline ring at room temperature, the general reaction formula is as follows , where R 1 , R 2 , R 3 , R 4 As described in the claims and description. The silver catalyst required for the reaction is one of silver trifluoromethanesulfonate, silver hexafluoroantimonate, silver tetrafluoroborate, and silver bistrifluoromethanesulfonimide. The reducing agent required for the reaction is Hans ester. The medium required for the reaction is: toluene. The implementation of the reaction is stirring at room temperature. The method of the invention has easy-to-obtain raw materials, simple operation, wide application range, good atom economy, green reaction and low price.

The invention discloses cyanide-free silver electroplating liquid, and belongs to the field of cyanide-free silver electroplating. The cyanide-free silver electroplating liquid is prepared by the following raw materials: 10-60 g / L of silver tetrafluoroborate, 0.1-1.5 g / L of methylpentynol, 0.1-1.2 g / L of 1, 4 butynediol, 10-20 g / L of ammonium acetate, 7-20 g / L of anisaldehyde, and 10-25 g / L of benzoic acid, wherein the pH value of the cyanide-free silver electroplating liquid is 3-7. The cyanide-free silver electroplating liquid contains no cyanide ions, reduces the harm of wastes to the environment and operators, is simple in preparation, and is easy to operate. The stable electroplating liquid can be obtained; the plating layer stress is low; and the bonding force is tighter.

The invention belongs to the technical field of precious metal preparation, and relates to a method for preparing bis(norbornadiene) rhodium tetrafluoroborate. After ion exchange reaction with silver tetrafluoroborate, red bis(norbornadiene) rhodium tetrafluoroborate solid is obtained by pressure filtration. The preparation method is simple, and the yield and purity of bis(norbornadiene) rhodium tetrafluoroborate product are improved. , reducing production costs.

The invention provides a method for synthesizing diarylmethylphosphonate derivatives containing different substituted functional groups with high efficiency and high selectivity. The method adopts silver tetrafluoroborate as a catalyst, and uses trialkyl phosphite and 4- Arylmethylene-2,6-di-tert-butyl-2,5-cyclohexadiene-1-ketone compounds are used as reaction substrates, and an organic solvent is added to the reaction system. The advantages of this method are as follows: the catalyst is cheap and easy to obtain; the substrate has high applicability; the reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as 90%. The method solves the shortcomings of traditional synthesis of diarylmethyl substituted phosphonate derivatives, such as poor reaction selectivity, cumbersome reaction steps, low yield and the need to use environmentally harmful reagents, and has good industrial application prospects. The present invention also provides corresponding diarylmethyl substituted phosphonate derivatives with different substituted functional groups.

The invention relates to a method for preparing silver tetrafluoroborate, comprising the following steps: mixing and reacting a fluoroboric acid source and a silver salt in a reaction medium to obtain silver tetrafluoroborate; wherein, the fluoroboric acid source is selected from tetrafluoroboric acid At least one of salt and tetrafluoroboric acid; the reaction medium is a mixed solvent of the first organic solvent and water or water, and the first organic solvent is selected from at least one of ether, nitromethane and toluene. The preparation method has wide applicability to raw materials, and the raw materials are low-toxic and easy to obtain, avoiding the problem of too much toxicity of using silver fluoride and boron trifluoride as reaction raw materials, and can react at room temperature, with mild reaction conditions and easy operation. Moreover, the required time is short, the requirements for equipment are low, and the production safety problem is guaranteed.

The invention discloses a preparation method of vinorelbine. The method comprises the following steps: taking anhydrovinblastine as a raw material; performing a bromination reaction to prepare bromide; and then performing separation by alumina column chromatography. The bromide is condensed and cyclized to vinorelbine during a column chromatographic separation process without using silver tetrafluoroborate and tetrahydrofuran, and product purity can be up to 65% (HPLC). The method helps avoid using the expensive silver tetrafluoroborate reagent, shorten process flow, lower raw material cost and reduce environmental pollution; meanwhile, the method also helps solve the disadvantages of unstable product quality, yield and the like in a silver tetrafluoroborate process and has good popularization and application prospect.

The invention discloses a surface treatment process of an integrated circuit lead frame. The surface treatment process is characterized by mainly comprising the following steps of oil removal, acid activation, copper plating, silver-tin alloy plating, copper protection, surface treatment and post-treatment. The surface treatment process has the advantages that copper tetrafluoroborate is used as main salt of a copper plating solution, silver tetrafluoroborate and stannous fluoroborate serve as main salt of a silver-tin alloy plating solution, the plating solution does not contain cyanide, is simple in component, healthy and friendly to the environment and workers, reasonable in formula and good in solution stability, on the premise that the quality of a plating layer is guaranteed, the current density is large, the electroplating speed is high and can reach 10 m / min, the electroplating efficiency is high, and the obtained integrated circuit lead frame is high in weldability, uniform in thickness, consistent in brightness, suitable for industrial production and cyclic utilization of liquid medicines, and conforms to the concept of green and environment-friendly production.

The invention belongs to the technical field of medicine, and particularly relates to a pyridino-[2',1':2,3]piperidine[1,6-a] pyrrole salt and a synthesis method thereof. Under the insert gas protection, 2-(1H-pyrrole-1-yl) naphthyridine, aromatic alkyne, cobalt catalysts, silver acetate AgOAc, cupric acetate monohydrate Cu(OAc)2.H2O, silver tetrafluoroborate AgBF4 and organic solvents are sequentially added into a reaction pipe; stirring reaction is performed for 16 to 30h under the condition of 130 to 140 DEG C; after the reaction is completed, the reaction pipe is cooled to the room temperature; a reaction mixture is subjected to desalting, washing, concentration and purification to obtain a target product. The pyridino-[2',1':2,3]piperidine[1,6-a] pyrrole salt provided by the invention belongs to important alkaloid, has the advantages that high biological activity or even high medical values are realized; the steps of the synthesis method are simple; the yield can reach 84 percent; the yield is high.

The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.

The invention provides a monovalent silver-catalyzed synthesis method for an azaindole seven-membered ring, belonging to the field of organic synthesis. In a general reaction formula as described in the specification, R1, R2 and R3 are as defined in the claims and the specification. A silver catalyst needed in a reaction is one selected from a group consisting of silver trifluoromethanesulfonate,silver hexafluoroantimonate, silver tetrafluoroborate and silver bis(trifluoromethanesulfonimide). A medium needed in the reaction is toluene. The reaction is carried out at room temperature under thecondition of stirring. The method has the advantages of easy availability of raw materials, simple operation, a wide application scope, good atomic economy, green reaction, and low price.

The invention relates to a preparation method of tetrakis (acetyl nitrile) silver tetrafluoroborate, which comprises the following steps: mixing and dissolving silver nitrate and acetonitrile to prepare a first reaction solution; and mixing the first reaction solution with ammonium fluoroborate for reaction to prepare the tetrakis (acetylacetonitrile) silver tetrafluoroborate. According to the preparation method of tetrakis (acetylacetonitrile) silver tetrafluoroborate provided by the invention, proper silver salt and fluoroborate are selected as raw materials, and acetonitrile, which is one of the reaction raw materials, is directly used as a reaction solvent, so that the tetrakis (acetylacetonitrile) silver tetrafluoroborate prepared by the method has few impurities, and the tetrakis (acetylacetonitrile) silver tetrafluoroborate has excellent storage stability through test verification; deterioration is avoided after long-time storage. Meanwhile, the preparation method also realizes maximization of reaction atom economy, meets the requirements of sustainable development of the modern society, is simple to operate and low in production cost, and has a great industrial application prospect.