A new method for preparing diarylmethyl substituted phosphonates

Abstract

The invention provides a method for synthesizing diarylmethylphosphonate derivatives containing different substituted functional groups with high efficiency and high selectivity. The method adopts silver tetrafluoroborate as a catalyst, and uses trialkyl phosphite and 4- Arylmethylene-2,6-di-tert-butyl-2,5-cyclohexadiene-1-ketone compounds are used as reaction substrates, and an organic solvent is added to the reaction system. The advantages of this method are as follows: the catalyst is cheap and easy to obtain; the substrate has high applicability; the reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as 90%. The method solves the shortcomings of traditional synthesis of diarylmethyl substituted phosphonate derivatives, such as poor reaction selectivity, cumbersome reaction steps, low yield and the need to use environmentally harmful reagents, and has good industrial application prospects. The present invention also provides corresponding diarylmethyl substituted phosphonate derivatives with different substituted functional groups.

Description

technical field [0001] The invention relates to the field of application catalysis synthesis of organophosphorus compounds, in particular to a kind of compound based on trialkyl phosphite and 4-arylmethylene-2,6-di-tert-butyl-2,5-cyclohexanediol The invention discloses a preparation method for preparing diarylmethyl substituted phosphonate derivatives by efficient reaction of alken-1-one compounds. Background technique [0002] Diarylmethyl substituted organophosphonates are an important class of intermediates in organic synthesis. They are widely used in the preparation of pharmaceutical structural substances, optoelectronic materials, efficient flame retardants, and catalyst ligands. [0003] In the process of phosphorylation, tri-coordinate phosphorus reagents are finally converted into tetra-coordinate phosphorus compounds, especially tetra-coordinate phosphorus compounds containing high-energy phosphoryl groups (P=O). In the reaction process of tri-coordinate phosphor...

AI Technical Summary

Problems solved by technology

However, the above methods generally use air-sensitive reagents (phosphoryl chloride, etc.), special ligands (ferrocene ligands, carbene ligands, etc.), and there are still cumbersome experimental steps, expensive catalysts, and difficult recycling. Harsh conditions, cross-substrate applicability, low yield, and large environmental pollution

[0005] So far, the efficient synthesis of diarylmethyl-substituted organic phosphonate compounds has several aspects, such as raw material quality, production safety (compounds such as phosphorus oxychloride are highly corrosive), and product stability and purity. The difficulty of synthesis technology is quite difficult. At present, only a few companies in the United States, Japan and other countries are producing, while the current situation of my country's high-end organic phosphonate products mainly depends on imports.