41results about How to "The reaction process is mild and easy to control" patented technology

The invention provides a method for efficiently and high-selectively compounding chiral R- / S- diaryl methyl substituted chiral organic phosphonate derivatives containing different substituting functional groups. Cesium carbonate is taken as a catalyst; chiral P(O)-H compound and 4-aryl methylene-2,6-di-tert-butyl-2,5-cyclohexadiene-1-ketone compounds are taken as reaction substrates; an organic solvent is added into a reaction system. The method has the advantages that the catalyst is low-cost and can be easily acquired; the substrates are high in applicability; the reaction conditions are mild, safe and reliable; the three-dimensional enantioselectivity of the acquired target product is above 99% and the yield is above 80%. The method can overcome the defects of low enantioselectivity, complex reaction steps, and the like, of the traditional reaction for compounding chiral R- / S- diaryl methyl substituted chiral organic phosphonate derivatives, can avoid the traditional chiral resolution method and has an excellent industrial application prospect. The invention also provides the corresponding chiral R- / S- diaryl methyl substituted chiral organic phosphonate derivatives containing different substituting functional groups.

The invention provides a method for efficiently and highly selectively synthesizing 2-iodine-1-phosphoryl substituted alkane compounds containing different functional groups. N ‑Iodosuccinimide (NIS) is used as an accelerator, P(O)‑OH-containing compounds and olefins are used as reaction substrates, and an organic solvent is added to the reaction system. The advantages of this method are: the accelerator is cheap and easy to obtain; the substrate has high applicability; the reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as 90%. This method develops a new way to synthesize substituted 2-iodo-1-phosphoryl substituted alkane compounds containing different functional groups, and solves the problems of poor reaction selectivity, cumbersome reaction steps, It has the disadvantages of low yield and the need to use harmful reagents to the environment, and has good industrial application prospects. The present invention also provides corresponding 2-iodo-1-phosphoryl substituted alkane derivatives substituted with different functional groups.

The invention provides a method for efficiently and highly selectively synthesizing o-diaryl phosphoryl-substituted phenolic derivatives containing different functional groups, which uses water as a catalyst to synthesize diaryl derivatives containing P(O)-H bonds The phosphorus oxy compound and the 4,4-dimethoxy-2,5-cyclohexadiene-1-ketone compound are used as reaction substrates, and an organic solvent is added to the reaction system. The method has the advantages that the catalyst is cheap and easy to obtain; the substrate has high applicability; the reaction condition is mild, safe and reliable; the yield of the obtained target product is as high as more than 90%. The method solves the shortcomings of traditional synthesis of o-diaryl phosphoryl substituted phenol derivatives such as poor reaction selectivity, cumbersome reaction steps, low yield, and the need to use harmful reagents to the environment, and has good industrial application prospects. The present invention also provides corresponding o-diaryl phosphoryl substituted phenol derivatives containing different functional groups.

The invention discloses a size-controllable Schiff base-type polymer nano-particle, which is prepared through a Schiff base reaction to 2,6-diaminopyridine and formalin, wherein molar ratio of the 2,6-diaminopyridine to formaldehyde in the formalin is 1:2-18. The invention also provides a preparation method of the size-controllable Schiff base-type polymer nano-particle with the 2,6-diaminopyridine and formalin as raw materials. The particle size of the size-controllable Schiff base-type polymer nano-particle can reach 120 nm to lowest. The preparation method is simple and environment-friendly and is carried out entirely in deionized water, has mild and easy-to-control reaction conditions, saves production cost and is easy to carry out in industrial production.