The invention provides a new method for efficiently and highly selectively synthesizing 2'-iodo[1,1'-biaryl]-2-organophosphonate compounds containing different functional groups, which uses cheap transition metal copper The salt is used as a catalyst, and the compound containing P(O)-OH and bisaryltrifluoromethanesulfonic acid periodiodium salt is used as a reaction substrate, and an organic solvent and a base are added to the reaction system. The advantages of the method are: the catalyst is cheap and easy to obtain; the substrate has high applicability; the reaction conditions are mild, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as more than 90%. The method solves the shortcomings of the traditional synthesis of 2'-iodo[1,1'-biaryl]-2-organophosphonate compounds, such as poor reaction selectivity, cumbersome reaction steps, low yield, and the need to use environmentally harmful reagents. , has good industrial application prospects. The present invention also provides corresponding 2'-iodo[1,1'-biaryl]-2-organophosphonate derivatives substituted with different functional groups.