A method for preparing o-diaryl phosphoryl substituted phenol derivatives
A technology of diarylphosphoryl and diarylphosphoryl oxide is applied in the field of preparing o-diarylphosphoryl substituted phenol derivatives, which can solve the problems of harsh reaction conditions, raw material quality and safety, product stability and purity, bottom line The problem of poor physical applicability, etc., achieves the effects of mild and easy control of the reaction process, good industrial application prospects, high yield and selectivity.
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Embodiment 1
[0025] 101 mg (0.5 mmol) of diphenylphosphine, 115.5 mg (0.75 mmol) of 4,4-dimethoxy-2,5-cyclohexadien-1-one, 0.005 mmol of catalyst (benzoic acid , formic acid, acetic acid, p-toluenesulfonic acid, salicylic acid, methanedisulfonic acid, water) and 1.0 mL toluene were added to the Schlenk tube under nitrogen atmosphere, at 100 o C stirred the reaction for 12 hours. By GC detection and analysis, when water is used as a catalyst, the yield of the above addition reaction is 79%.
Embodiment 2
[0027] 101 mg (0.5 mmol) of diphenylphosphine, 115.5 mg (0.75 mmol) of 4,4-dimethoxy-2,5-cyclohexadien-1-one, water (0.005 mmol, 0.025 mmol , 0.05 mmol, 0.1 mmol, 0.25 mmol) and 1.0 mL of toluene were added to the Schlenk tube under nitrogen atmosphere, at 100 o C stirred the reaction for 12 hours. Through GC analysis, when the amount of water used was 0.05 mmol, the yield of the above addition reaction was 94%.
Embodiment 3
[0029] Mix 101 mg (0.5 mmol) of diphenylphosphine, 0.5-1.0 mmol) of 4,4-dimethoxy-2,5-cyclohexadien-1-one, 0.05 mmol of water and 1.0 mL of toluene in Into the Schlenk tube under nitrogen atmosphere, at 100 o C stirred the reaction for 12 hours. Through GC analysis, when the amount of 4,4-dimethoxy-2,5-cyclohexadien-1-one is 0.75 mmol, the yield of the above addition reaction is 94%.
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