Method using aryl diazonium tetrafluoroborate and nitrile to prepare organic amide compounds
A technology for diazonium tetrafluoroborate and compound is applied in the field of efficient preparation of organic amide compounds and derivatives thereof, which can solve the problems of overlapping substrate applicability, cumbersome experimental steps, harsh reaction conditions, etc., and achieves high efficiency. Selective, simple method, simple to prepare effect
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Embodiment 1
[0033] Add 96 mg (0.5 mmol) of phenyldiazonium tetrafluoroborate, 0.1 mmol of cuprous iodide, 0.5 mmol of potassium phosphate and 1.0 mmol of water into the Schlenk tube under nitrogen atmosphere, and add 1 mL of organic solvent (acetonitrile, ethyl acetate, dichloromethane, N,N -dimethylformamide, tetrahydrofuran, dioxane, toluene, thionyl chloride, methanol), at 80 o C stirred the reaction for 12 hours. By GC detection and analysis, when acetonitrile was used as the reaction solvent, the yield of the crosslinking reaction was 93%.
Embodiment 2
[0035] 96 mg (0.5 mmol) of phenyldiazonium tetrafluoroborate, 0.1 mmol of catalyst (cuprous iodide, cuprous chloride, cuprous bromide, copper bromide, copper chloride, copper acetate, sulfur Cuprous cyanate, cuprous oxide, cupric oxide), 0.5 mmol of potassium phosphate and 1.0 mmol of water were added to the Schlenk tube under nitrogen atmosphere, and 1 mL of acetonitrile was added under air condition, at 80 o C stirred the reaction for 12 hours. By GC detection and analysis, when cuprous iodide is used as a catalyst, the yield of the crosslinking reaction is 93%.
Embodiment 3
[0037] Add 96 mg (0.5 mmol) of phenyldiazonium tetrafluoroborate, 0.1 mmol of cuprous iodide, 0.5 mmol of base (triethylamine, potassium phosphate, potassium carbonate, sodium carbonate, cesium carbonate, sodium acetate, Sodium tert-butoxide, sodium hydroxide, potassium hydroxide, 1,8-diazabicyclo[5.4.0]undec-7-ene, N,N -diisopropylethylamine, dimethylaniline) and 1.0 mmol of water were added to the Schlenk tube under nitrogen atmosphere, and 1 mL of acetonitrile was added under air condition, at 80 o C stirred the reaction for 12 hours. By GC detection analysis, when potassium phosphate is used as the base, the yield of the crosslinking reaction is 93%.
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