646 results about "Aminopyridines" patented technology

The invention relates to the technical field of biosynthesis, and particularly discloses a pyridone compound as well as a biosynthesis method and application thereof. On the basis of related technologies of synthetic biology, non-ribosome peptide synthetase is modified, non-ribosome peptide synthetase mutants are heterologously expressed in various hosts, a pyridone compound is found and obtained for the first time, the chemical molecular formula of the pyridone compound is determined to be C5H4N2O3, and the pyridone compound is named as 5-aminopyridine-2, 3, 6-triketone or 5-hydroxy-3-iminopyridine-2, 3, 6-triketone or 5-hydroxy-3-iminopyridine-2, 3, 6-triketone or 5-hydroxy-3-iminopyridine-2, 3, 6-triketone. The novel pyridone compound can be used as a raw material or an intermediate to be applied to development and preparation of novel antibiotics, drugs and dyes.

The invention discloses a flame-retardant high-temperature-resistant fiber and a preparation method thereof, and relates to the technical field of fibers. When the flame-retardant high-temperature-resistant fiber is prepared, 1, 6-hexamethylenediamine, 1, 6-adipic acid, tetrahydrodifuran [3, 4-B: 3 ', 4'-D] furantetraone and a phosphorus-sulfur composite flame retardant are copolymerized to generate a polyamide-polyamide acid solution; 4-aminopyridine and the polyamide-polyamide acid solution are subjected to a reaction, and modified polyamide is prepared; the modified polyamide is subjected to melt spinning, and polyamide fibers are prepared; the preparation method comprises the following steps: pretreating nano titanium dioxide by using 4-bromobutyl trimethoxy silane to prepare modified nano titanium dioxide; mixing the modified nano titanium dioxide and ethanol to prepare a light-resistant antibacterial finishing agent; and carrying out post-treatment on the polyamide fiber by using an anti-light antibacterial finishing agent to prepare the flame-retardant and high-temperature-resistant fiber. The prepared fiber is excellent in comprehensive performance, particularly outstanding in flame retardance and high temperature resistance, and suitable for the fields of special protective clothing, high-temperature filtering materials and the like.

The invention discloses a method for detecting the residual quantity of dextran sulfate sodium in an antibody. Specifically, the invention provides a method for detecting the residual quantity of dextran sulfate sodium in an antibody, which comprises the following steps: removing protein in the antibody, and reacting with a 2-aminopyridine solution; a high performance liquid chromatography method is adopted to detect a test sample and sodium dextran sulfate standard substances with different concentrations. The detection method disclosed by the invention is low in detection limit, high in accuracy and suitable for analyzing the residual quantity of dextran sulfate in the antibody.

The invention belongs to the technical field of biological medicine, and discloses an engineering bionic exosome with an anti-aging effect and a preparation method and application thereof, and the preparation method comprises the following steps: (S1) preparing a bionic cell membrane modified targeting ligand: adding collagen, mitochondrial targeting polypeptide, a condensing agent and 4-dimethylaminopyridine into an organic solvent, and stirring to obtain the bionic cell membrane modified targeting ligand; activating under a protective atmosphere, and then adding lysine into the system to react, so as to obtain a bionic cell membrane modified targeting ligand; and (S2) embedding the bionic cell membrane modified targeting ligand into the engineered exosome bionic membrane, and entrapping an active substance to form the engineered bionic exosome. The exosome provided by the invention has better skin permeability, mitochondrial targeting effect and cell endocytosis effect, has better protection effect on mitochondria, and can realize efficient delivery of active substances.

The invention belongs to the technical field of catalyst preparation, focuses on a high-entropy alloy nanowire catalyst, and mainly relates to a preparation method and application of an AuCuAgPtNi catalyst. A one-pot wet chemical method is innovatively adopted, a 4-aminopyridine solvent and metal precursors of gold, copper, silver, platinum and nickel are fully and evenly mixed and placed in an oil bath pot at the temperature of 90 DEG C, then a reducing agent ascorbic acid is rapidly added, after specific reaction time, washing, drying and other operations are sequentially carried out, and the high-entropy alloy nanowire AuCuAgPtNi catalyst can be successfully prepared. The preparation method disclosed by the invention has the remarkable advantages of simple process, simple steps, convenience in operation and the like. In an alkaline environment, the prepared nanowire-shaped high-entropy alloy AuCuAgPtNi catalyst shows extremely excellent catalytic activity and selectivity for catalytic degradation of waste plastic polylactic acid, the waste plastic can be efficiently upgraded and converted into pyruvic acid, a new way is opened up for resource utilization of the waste plastic, and the application prospect is wide. The method has a wide application prospect in the fields of environmental protection and resource recovery.

This application relates to the field of biosynthesis technology, and specifically discloses a pyridone compound, its biosynthesis method and application. Based on synthetic biology-related technologies, this application modifies non-ribosomal peptide synthetase, heterologously expresses non-ribosomal peptide synthetase mutants in a variety of hosts, and for the first time discovers and obtains a pyridone compound, and determines its chemical formula as C5H4N2O3, named 5-amino-pyridine-2,3,6-trione or 5-hydroxy-3-imino-pyridine-2,6-dione. This novel pyridone compound can be used as a raw material or intermediate in the development and preparation of novel antibiotics, drugs and dyes.

The invention relates to the technical field of pigment synthesis, and particularly discloses a synthetic method of ornamental blue. According to the synthetic method, 5-hydroxy-3-iminopyridine-2, 6-diketone is adopted as a raw material, enol interconversion is performed on the raw material under the alkaline condition (under the action of an alkali catalyst), heating is performed, and chemical condensation reaction is performed to obtain the ornamental blue. The synthetic method of the ornamental blue provided by the invention is simple in process and high in reaction selectivity, the yield and purity of the product are high, the yield of the ornamental blue product is more than or equal to 80%, the purity of the ornamental blue product is more than 99%, the synthetic method has obvious advantages, no potential safety hazard exists in the process, and industrial production can be realized.

The invention belongs to the technical field of organic synthesis, and particularly discloses an ammonia aromatic alkene modified near-infrared BODIPY fluorescent probe as well as a preparation method and application thereof.The near-infrared BODIPY fluorescent probe is obtained by adopting 6-(dimethylamino) nicotinic aldehyde to directionally modify the alpha position of BODIPY and constructing an expanded conjugated system through Knoevenagel condensation. Wherein dimethylamino provides a strong electron donating effect, a molecular structure is twisted into a non-planar configuration due to steric hindrance of a pyridine ring, pi-pi accumulation is reduced, and an ACQ effect is inhibited. According to the structural modification strategy, significant red shift of absorption / emission wavelength is realized by expanding a molecular pi-conjugated skeleton, and meanwhile, the stability of the BODIPY core and the quantum yield are effectively enhanced. The probe molecule can specifically recognize the diphenylalanine dipeptide structural unit by utilizing the synergistic coordination effect of the 2-aminopyridine derivative and the BODIPY mother nucleus, so that the selective detection of the Alzheimer's disease biomarker Abeta42 is realized, and a novel optical detection tool is provided for the early molecular diagnosis and targeted therapy of AD (Alzheimer's disease).

The invention discloses a synthesis method of bromo-triazine, which belongs to the technical field of organic synthesis, and comprises the following steps: preparing an alumina-loaded N, N-dimethylaminopyridine catalyst, filling the alumina-loaded N, N-dimethylaminopyridine catalyst in a fixed bed reactor, introducing tribromophenol and metal oxide mixed slurry and cyanuric chloride slurry, carrying out a reaction for 2-4 hours, and carrying out a reaction for 2-4 hours to obtain the bromo-triazine. Raising the temperature for reaction to obtain a crude product solution; and performing post-treatment to obtain a bromo-triazine product. According to the invention, the aluminum oxide loaded N, N-dimethylaminopyridine catalyst is synthesized, and the N, N-dimethylaminopyridine enables the reaction speed to be higher and the yield to be higher; nano aluminum oxide is adopted for loading, so that on one hand, dealkalization synthesis of bromotriazine is realized, and on the other hand, the reaction efficiency is accelerated; the continuous process realizes non-aqueous medium and low-temperature short-time reaction, so that hydrolysis is further avoided; the aluminum oxide loaded N, N-dimethylaminopyridine catalyst is high in activity and stability, the synthesis method is simplified, and the aluminum oxide loaded N, N-dimethylaminopyridine catalyst is suitable for industrial large-scale production.

The invention belongs to the technical field of wave-absorbing materials, and particularly relates to a monatomic modified carbon composite wave-absorbing material and a preparation method thereof. The method specifically comprises the following steps: S1, uniformly dispersing a pyrrole monomer and molybdenum trioxide hydride by using a solvent, and reacting at room temperature for 3-6 hours to obtain an HM-PPy compound; s2, adding metalloporphyrin and thionyl chloride into N, N-dimethylformamide, uniformly mixing, and then adding 4-dimethylaminopyridine to obtain a raw material solution; s3, dispersing the HM-PPy compound into a N, N-dimethylformamide solution containing triethylamine, so as to obtain a turbid liquid; s4, dropwise adding the raw material solution into the turbid liquid, and stirring and reacting at room temperature for 20-25 hours to obtain HM-PPy-MPor; and S5, carrying out pyrolysis on the HM (at) PPy-MPor to obtain the monatomic modified carbon composite wave-absorbing material.

The invention discloses a preparation method of 5-hydroxy-3-iminopyridine-2, 6-diketone, and relates to the technical field of compound preparation. The invention provides a preparation method of 5-hydroxy-3-iminopyridine-2, 6-diketone, which comprises the following steps: uniformly mixing observation blue with at least one oxidant of sodium hypochlorite, potassium permanganate and hydrogen peroxide according to a molar ratio of 1: (0.5-1.5) under a solution condition, reacting for 5-120 minutes, and adding a reducing agent to finish the reaction, thereby obtaining a target product. According to the preparation method provided by the invention, on the basis of the amide structure of the ornamental blue, 'endogenous catalysis' of the reaction can be realized, no additional catalyst needs to be introduced, and the 5-hydroxy-3-iminopyridine-2, 6-diketone with the yield of more than 60.53% and the purity of more than 60.2% can be prepared through a simple and convenient one-step reaction.

The present invention provides compositions and methods for preventing, alleviating, or treating subjects having toxic agent-induced injury. The present invention also provides compositions and methods for preventing, alleviating or treating tissue damage caused by exposure to toxic agents or restoring at least a portion of normal tissue function. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising at least one potassium channel blocker. In some embodiments, the potassium channel blocker includes 4-aminopyridine, a derivative thereof, or a combination thereof. In some embodiments, the pharmaceutical compositions may be administered with additional therapeutic agents, such as anticonvulsions.

The invention provides an antistatic polypropylene material as well as a preparation method and application thereof, and belongs to the technical field of polypropylene materials. The preparation method comprises the following steps: modifying graphene, preparing a graphene / titanium dioxide compound, reacting, and performing extrusion molding. The method comprises the following reaction steps: putting a functionalized graphene / titanium dioxide compound into a reaction container, introducing N, N-dimethylformamide, uniformly stirring, adding modified graphene, dicyclohexylcarbodiimide and 4-dimethylaminopyridine, heating to 73-77 DEG C, carrying out ultrasonic treatment, and after ultrasonic treatment is finished, carrying out heat preservation stirring for 1.8-2.2 hours to obtain the graphene / titanium dioxide composite material. Then heating to 116-123 DEG C at the speed of 1.7-2.3 DEG C / min, stirring for 1.8-2.2 hours while keeping the temperature, after stirring is finished, filtering, washing, freeze-drying, and naturally recovering to room temperature, so as to obtain a graphene-graphene / titanium dioxide compound; the antistatic polypropylene material prepared by the invention is good in antistatic property, excellent in mechanical property and good in aging resistance.

The invention discloses a temperature change resistant glass material and a preparation method thereof, and relates to the field of glass. When the temperature change resistant glass material is prepared, crystal whisker silicon is soaked in an aluminum hydroxide solution, and then the crystal whisker silicon, nano silicon dioxide, lithium oxide, sodium carbonate and titanium dioxide are heated, mixed and annealed to prepare glass; the preparation method comprises the following steps: sequentially reacting aluminum oxide with 3-aminopropyltrimethoxysilane, 4-bromo-2-hydroxybenzaldehyde and 4-aminopyridine, so as to prepare functionalized aluminum oxide; the preparation method comprises the following steps: carrying out a reaction on polyaspartic acid ester resin, a hexamethylene diisocyanate-based polyisocyanate tripolymer, a functional monomer and an end-capping reagent to prepare modified polyurea; and mixing the modified polyurea with the functionalized aluminum oxide to prepare a coating material, spraying the coating material on the surface of glass, and drying to prepare the temperature-change-resistant glass material. The temperature-change-resistant glass material prepared by the invention has the capabilities of fouling prevention, heat conduction, impact resistance, coating self-repairing and aging resistance.

The invention relates to a high-strength high-toughness high-temperature-resistant epoxy resin adhesive as well as a preparation method and application thereof. The high-strength high-toughness high-temperature-resistant epoxy resin adhesive comprises the following components: epoxy resin, a curing agent, an organic solvent, a curing accelerator and an inorganic filler, wherein the curing accelerator is a 2-methoxy group 6-methylaminopyridine-boron trifluoride complex, and the curing accelerator is a 2-methoxy group 6-methylaminopyridine-boron trifluoride complex. According to the epoxy resin adhesive, the adopted curing accelerator can play a role in avoiding pre-curing, on the other hand, the curing temperature can be reduced, and the epoxy resin adhesive is low in preparation cost, high in process efficiency and good in modification effect and has a good market application prospect.

The invention provides an imidazo [1, 2-alpha] pyridine stimuli-responsive molecule with a D-A twisted structure as well as a preparation method and application of the imidazo [1, 2-alpha] pyridine stimuli-responsive molecule, belongs to the technical field of intelligent materials, and is used for solving the technical problem that intelligent materials for developing stimuli-responsive molecules for data encryption and information anti-counterfeiting are insufficient. The preparation method of the compounds N1 and N3 comprises the following steps: 2-aminopyridine and 2, 4 '-dibromoacetophenone are subjected to an amphiphilic reaction to obtain a compound a; the compound a and POCl3 are subjected to a Vilsmeier-Haack reaction, and a compound b is obtained; carrying out Suzuki coupling reaction on the compound a or the compound b and triphenylamine boric acid to obtain a compound N1 or N2; the compound N2 and malononitrile are subjected to a Knovenagel condensation reaction, and a compound N3 is obtained. The compound prepared in the invention has good fluorescence emission capability in a solution and a solid state and a grinding solvent acid / alkali stimulated fluorescence discoloration behavior, and can realize good data encryption and information anti-counterfeiting.

The invention discloses a preparation method and application of a reactive flame retardant containing double DOPO groups and nitrogen heterocycles, and the preparation method of the reactive flame retardant comprises the following steps: adding an amino compound R-NH2 and terephthalaldehyde into a reactor with a stirring device, adding a solvent, adding an acid to adjust the pH value to 6, then heating until the solvent is refluxed, keeping the refluxing temperature to react for a period of time, and cooling to room temperature to obtain the reactive flame retardant containing double DOPO groups and nitrogen heterocycles. Reaction liquid containing an imine intermediate product is obtained; then adding DOPO, controlling the reaction temperature to be the solvent reflux temperature, and keeping the reflux temperature to react for a period of time; after the reaction is finished, cooling, carrying out suction filtration, washing and drying to obtain a reaction type flame retardant containing double DOPO groups and nitrogen heterocyclic rings; the reaction formula is as follows: # imgabs0 # amino compound R-NH2 is 4-aminopyridine or 3-aminopyrazole, namely R is pyridyl or pyrazolyl. The synthesis and purification method of the flame retardant is simple, the reaction yield is high, and the flame retardant effect of epoxy resin can be remarkably improved by adding the flame retardant into bisphenol A epoxy resin through modification.

The invention relates to the technical field of coatings, and discloses a functionalized graphene modified polyurethane composite coating, compared with a labyrinth shielding structure of a traditional polyurethane coating, the functionalized graphene modified polyurethane composite coating added with functionalized graphene can form a more compact film-shaped structure through layer-by-layer superposition of two-dimensional sheet structures of graphene, so that the graphene modified polyurethane composite coating has a good shielding effect. By means of the nanometer size, high surface hydrophobicity and conductivity of graphene, the corrosion rate of metal is reduced, the corrosion resistance and mechanical performance of a coating are improved, aminopyridine can improve the corrosion current and impedance value of a polyurethane coating film, the corrosion resistance of the polyurethane coating film is improved, and the corrosion resistance of the polyurethane coating film is improved. Through a blending preparation means, the chain segment of polyvinyl chloride is compatible with the flexible chain segment of polyurethane, and the mechanical property of the polyurethane coating is further improved.

The invention belongs to the technical field of organic synthesis, and provides a preparation method of a cationic lipid compound, which comprises the following steps: (1) reacting 1, 5-dihalopentane, 2-tert-butyl glycolate and alkali to obtain a product G; (2) hydrolyzing the product G under an acidic condition to obtain a product H; (3) carrying out esterification reaction on the product H, the raw material C, 4-dimethylaminopyridine and a condensing agent in dichloromethane to obtain a product J; and (4) carrying out amination reaction on the product J, the raw material L and alkali in acetonitrile to obtain the cationic lipid compound. Compared with the prior art, the method has the relatively remarkable advantages that when the first part of halogenated long-chain alkyl ester H is synthesized by the method, 1, 5-dihalopentane and 2-tert-butyl glycolate are used as raw materials, the halogenated long-chain alkyl ester J is synthesized by a simple method, the product is obtained at a higher yield in synthesis, and the method is suitable for kilogram-level production. The route synthesis only comprises four steps of chemical reactions, and is suitable for industrial production.

This document relates to methods and materials for using 4-aminopyridine (4-AP) and / or one or more derivatives of 4-AP. For example, a composition containing 4-AP and / or one or more derivatives of 4-AP can be administered (e.g., orally administered) to a mammal to increase a level of bone morphogenetic protein 2 (BMP-2) polypeptides within the mammal. For example, a composition containing 4-AP and / or one or more derivatives of 4-AP can be administered (e.g., orally administered) to a mammal having bone loss to increase the level of BMP-2 within the mammal, thereby treating the mammal's bone loss.

The invention belongs to the field of pesticide intermediates and product preparation, and particularly relates to a method for preparing trifluorobenzene pyrimidine. The method disclosed by the invention comprises the following steps: (1) in a first organic solvent, carrying out Schiff base condensation reaction on 2-aminopyridine and pyrimidine-5-formaldehyde under the action of a first moisture scavenger to generate N-2-pyridine-5-pyrimidine methylenimine; (2) in a second organic solvent, carrying out reductive amination reaction on the N-2-pyridine-5-pyrimidine methylenimine and hydrogen under the action of a catalyst to generate N-2-pyridine-5-pyrimidine methylamine; and (3) in a third organic solvent, carrying out cyclization reaction on the N-2-pyridine-5-pyrimidine methylamine and 2-(3-trifluoromethylphenyl) malonyl chloride in the presence of an acid-binding agent, so as to prepare the trifluorobenzene pyrimidine. According to the method disclosed by the invention, the post-treatment operation times and the reaction reagent consumption are greatly reduced, and efficient and green production is realized.

To provide 2-aminopyridine derivative compounds for use as inhibitors of nitric oxide synthase.SOLUTION: Disclosed are 2-aminopyridine derivative compounds for use as inhibitors of nitric oxide synthase (NOS). In particular, the field of the present invention relates to 2-aminopyridine derivative compounds for use as inhibitors of neuronal nitric oxide synthase (nNOS), which are formulated as pharmaceutical compositions for treating nNOS-associated diseases and disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, as well as amyotrophic lateral sclerosis, cerebral palsy, stroke / ischemic brain injury, and migraine headaches.SELECTED DRAWING: Figure 1

The invention relates to the technical field of removal of carbon dioxide in oil gas, in particular to a preparation method of carbon dioxide PAMAM grafted ionic liquid for oil gas purification. Comprising the following steps: 1) activating carboxyl: dissolving 1-butyl-3-methylimidazole carboxylic acid in a solvent, adding dicyclohexylcarbodiimide and 4-dimethylaminopyridine, and stirring at room temperature to generate active ester; 2) grafting PAMAM: adding PAMAM dendrimer into the solution, and reacting under the protection of nitrogen; and 3) purification: removing the dicyclohexylurea precipitate through centrifugation, and dialyzing the filtrate to remove the unreacted ionic liquid and small molecule byproducts to obtain the PAMAM grafted ionic liquid. The stability and durability of the absorbent are remarkably improved, the CO2 absorption efficiency is improved, the energy consumption of the absorbent per unit mass is reduced, and the preparation method is simple and controllable, mild in reaction condition and easy for large-scale production.

The invention discloses application of a carbon steel corrosion inhibitor based on combination of physical adsorption, chemical adsorption and hydrophobic barrier, and relates to the technical field of metal corrosion inhibition. The technical problem that a corrosion inhibitor in the prior art is low in corrosion inhibition efficiency in a high-temperature strong-acid environment is solved. The preparation method of the carbon steel corrosion inhibitor comprises the following steps: firstly, ultrasonically dissolving 4-aminopyridine to obtain a solution I; then, dropwise adding an isopropanol solution of 2, 3-epoxypropyltrimethylammonium chloride into the solution I according to a molar ratio of 1: 1, removing a solvent through a rotary evaporation method, washing with ethanol, centrifuging to obtain quaternized 4-aminopyridine, and drying the quaternized 4-aminopyridine; and finally, the dried quaternized 4-aminopyridine and bromododecane are added into acetonitrile for a reaction, diethyl ether is dropwise added into obtained reaction liquid for precipitation, and the quaternized 4-aminopyridine-bromododecane carbon steel corrosion inhibitor is obtained after drying. The prepared carbon steel corrosion inhibitor is high in corrosion inhibition efficiency in a high-temperature and strong-acid environment.

The invention discloses a preparation method of 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine as an elinnetin intermediate, and belongs to the technical field of medicine synthesis. According to the invention, cheap and easily available 3-nitro-4-hydroxypyridine is used as an initial raw material, and the 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine is synthesized at low cost and high yield through the steps of halogenation, coupling, hydroxylation, reduction, condensation and the like. The raw materials used in the whole process are simple and easy to obtain, the reaction conditions are milder, and the reaction route is short. According to the invention, the Suzuki coupling reaction is firstly carried out, and then the hydroxylation of the pyridine 2 position is carried out, so that the use of an anhydrous reagent and harsh anhydrous reaction conditions are effectively avoided, and the reaction cost is remarkably reduced. In addition, the method is easy and convenient to operate, good in stability, high in total yield and suitable for industrial large-scale production.

The invention discloses a polymer scale inhibitor and a preparation method thereof, and belongs to the technical field of macromolecules and water treatment. The polymer scale inhibitor has the following general formula: # imgabs0 #, wherein m, n and p are respectively any integer from 1 to 10. In addition, the invention also provides a preparation method of the polymer scale inhibitor, which comprises the following steps: mixing acrylic acid and water, then adding ACMO and 2-aminopyridine, then dropwise adding an initiator at 45-50 DEG C, and then reacting at 50-60 DEG C to obtain the polymer scale inhibitor. According to the polymer scale inhibitor provided by the invention, the scale inhibition performance of the scale inhibitor is remarkably improved.

The invention belongs to the technical field of hydrophobic materials, and particularly relates to transparent hydrophobic paper and a preparation method and application thereof.The preparation method comprises the steps that a reaction reagent n-decanoic acid is mixed with a catalyst, a condensing agent and an organic solvent to obtain a reaction solution, the catalyst is 4-dimethylaminopyridine, and the condensing agent is 4-dimethylaminopyridine; the condensing agent is 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and the solvent is a solvent; the transparent paper-based material is placed in a reaction solution to be subjected to esterification reaction, and the transparency of the transparent paper-based material is hardly influenced; the esterification reaction introduces a hydrophobic alkyl chain on the surface of the paper-based material, so that the hydrophobicity of the paper-based material is improved, the transparency of the paper-based material can be retained, and the film-forming property of PEDOT: PSS on a paper base is not influenced.

The invention discloses a method for detecting 2-chlorine-propylene glycol and 3-chlorine-propylene glycol, and belongs to the technical field of food pollutant detection. The method for detecting 2-chlorine-propylene glycol and 3-chlorine-propylene glycol comprises the following steps: purifying a sample solution to be detected through a purification column to obtain a purified solution; removing water from the purified liquid, and adding a derivatization reagent for derivatization treatment to obtain a derivative liquid; the derivatization reagent is prepared from quinolaldehyde acyl chloride and 4-dimethylaminopyridine; and carrying out liquid chromatography-mass spectrometry detection on the derivative solution. The method provided by the invention can effectively distinguish two MCPD isomers, shorten derivatization time (20-30 min), increase hydrophobicity, promote chromatographic separation and improve electrospray ionization mass spectrometry (ESI-MS) sensitivity, and breaks through the limitation that a traditional method is limited to GC-MS.

The invention belongs to the technical field of sewage treatment, and particularly relates to a composite carbon source additive and a preparation method thereof. The composite carbon source additive comprises the following components in parts by weight: 30-40 parts of bagasse, 8-12 parts of a polyvinyl alcohol derivative, 2-4 parts of a functional filler, 5-8 parts of potassium citrate and 5-8 parts of sodium pyruvate, the preparation process of the polyvinyl alcohol derivative comprises the following steps: adding polyvinyl alcohol, 1, 3, 5-benzene trisulfonic acid, triethylamine and 4-dimethylaminopyridine into dichloromethane to react, filtering, washing and drying; the polyvinyl alcohol derivative is obtained. The composite carbon source additive can be slowly released in the denitrification process and continuously and stably provide a carbon source, the denitrification process is promoted, and the denitrification efficiency is improved.

The invention discloses a carbon-doped carbon nitride nanotube as well as a preparation method and application thereof in photocatalytic reaction, and belongs to the technical field of inorganic photocatalytic nano materials. Comprising the following steps: roasting urea, melamine and 2, 4, 6-triaminopyridine under protective gas; adding the carbon-doped carbon nitride nanotube, 5-hydroxymethylfurfural and chloroplatinic acid hexahydrate into the deionized water; photocatalytic hydrogen evolution is started to cooperate with selective oxidation reaction of 5-hydroxymethylfurfural. The carbon-doped carbon nitride prepared by the preparation method disclosed by the invention is in a nanotube shape; and the catalyst can be effectively applied to solar photocatalytic hydrogen evolution to cooperate with selective oxidation of 5-hydroxymethylfurfural to generate 2, 5-diformyl furan. The invention mainly solves the problems that the value-added reaction cooperated with the hydrogen production process cannot be realized and the overall economic value cannot be improved in the traditional hydrogen production means. The method is an effective, practical and simple method, is suitable for laboratory preparation and industrial production, and has huge development space and application prospect.