36 results about "Aminopyridines" patented technology

The invention relates to novel herbicidal active compound combinations which comprise substituted isoxazolincarboxamides or agrochemical acceptable salts thereof and substituted aminopyridines and aminopyrimidines. They can be used with particularly good results for the control of weeds in various crops of useful plants.

This invention discloses a method for preparing sulfonamide-modified benzo[a]fluorene-5-one derivatives, using 1,7-enyne and N Using sulfonylaminopyridine salts as raw materials, a series of sulfonated benzo[a]fluorene-5-one compounds were successfully synthesized by catalyzing the sulfonation / cyclization tandem reaction of 1,7-enynes under photocatalytic conditions. This method has excellent functional group tolerance and high economic applicability.

This invention discloses a method for synthesizing cefotiam, using 7-aminocephalosporanic acid (7-ACA) as the parent nucleus and introducing a 4-dimethylaminopyridine-dimethyl carbonate composite catalytic system. The reaction is carried out in a one-pot process involving 3-position nucleophilic substitution, 7-position amidation, and simultaneous deprotection in a green mixed solvent of ionic liquid [BMIM]BF₄-water with 1-(2-dimethylaminoethyl)-1H-5-mercapto-tetrazole and compound I. This method simplifies the process, improves selectivity, produces a high-purity product with stable yield, and is suitable for industrial production.

The application relates to a salt type of a new cell cycle regulatory kinase inhibitor and a crystal form and a preparation method thereof, and relates to a succinate salt of a compound (6-((4-(2-(diethylamino)benzo[d]thiazol-6-yl)-5-fluoropyrimidin-2-yl)amino)pyridin-3-yl)(4-isopropylpiperazin-1-yl)methanone and a crystal form thereof, wherein two crystal forms II and III of the succinate salt are good in stability, high in solubility, and the preparation method is simple and suitable for industrial production.

The utility model discloses a multilayer mesh belt type drying device for 4-methylamino pyridine, including the casing, install conveying assembly on the casing, and conveying assembly includes first mesh belt, and first mesh belt sets up in the casing, and the inside of first mesh belt is provided with second mesh belt, and is provided with the feeding channel between second mesh belt and first mesh belt, the utility model discloses conveying assembly realizes automatic feeding in and out with two helical blades, and the gap of first mesh belt and second mesh belt is used as the feeding channel clamping conveying material, and through single motor will carry out synchronous drive, can reduce equipment cost and energy consumption, reduce the equipment volume, drying assembly is designed with baffle and air outlet pipe on every layer feeding channel, can realize the individual control of every layer feeding channel hot -blast flow, utilize the centralized collection of box to contain water vapor hot -blast, and through gas -liquid separation board filter out water vapor, again through the air blower and send into the heater, realize the recycling of hot -blast, can effectively improve material drying speed, reduce equipment energy consumption.

The application belongs to the field of organic material preparation, and particularly relates to a kind of poly-metal phthalocyanine-based porous organic material based on 4-dimethylamino pyridine hot melt method and preparation method and application.The method for preparing poly-metal phthalocyanine-based porous organic material based on 4-dimethylamino pyridine hot melt method comprises the following steps: mixing cyano-containing aromatic monomer, metal element and 4-dimethylamino pyridine, placing in a closed reaction container, heating to a temperature above the melting point of 4-dimethylamino pyridine under the condition of no additional solvent, and then reacting; after the reaction is completed, the product is washed and purified to obtain poly-metal phthalocyanine-based porous organic material. The application utilizes 4-dimethylamino pyridine as a reaction medium and an efficient nucleophilic catalyst, and establishes a general synthesis platform for synthesizing polyphthalocyanine porous material from cyano monomers.

The application discloses a kind of multi-functional group dynamic crosslinking polymer preparation methods for perovskite photovoltaic device, comprising: end hydroxyl polydimethylsiloxane, diselenoic acid, dopamine, 4-dimethylaminopyridine, condensing agent and solvent.By the above mode, the multi-functional group dynamic crosslinking polymer preparation method for perovskite photovoltaic device of the application greatly improves the mechanical properties and photoelectric efficiency of perovskite photovoltaic device, and the environmental stability of perovskite photovoltaic device is also improved, and has self-repairing function, effectively prolongs service life.

The present application relates to a kind of valsartan-2-amino pyridine co-amorphous and preparation method, the co-amorphous of valsartan-2-amino pyridine of the present application is with 2-amino pyridine according to specific proportion mixed, using solvent evaporation method to prepare single-phase amorphous binary system, the present application uses the interaction between 2-amino pyridine and valsartan, forms ternary hydrogen bond connection mode, greatly improves the solubility and dissolution of valsartan, improves bioavailability, and cost is low, energy consumption is low, can large-scale industrial production.

The application belongs to the technical field of catalyst preparation, and relates to a preparation method and application of a CoCuNiPtRu high-entropy alloy nanoparticle catalyst. A one-pot wet chemical method is used to uniformly mix 4-amino pyridine solvent and metal precursors, and then ascorbic acid is quickly added for reduction in an oil bath at 95 DEG C. After reaction, washing and drying, the catalyst is obtained. The method has the advantages of simple process and convenient operation. The obtained catalyst has high activity and selectivity in catalytic degradation of polylactic acid waste plastics under alkaline conditions, can efficiently upgrade and convert the polylactic acid waste plastics into acetic acid, provides a new way for resource utilization of waste plastics, and has good environmental protection and resource recycling prospects.

The present invention relates to a method for efficiently producing a compound derived from the commercially available and readily available 3-((3S)-7-bromo-2-((2-hydroxypropyl)amino)-5-(pyridin-2-yl)-3H-benzo[e][1,4]diazepine-3-yl)propionate methyl ester, namely, the compound 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propionate methyl ester benzenesulfonate (remimazolam besylate).

The application discloses a kind of Ni3N-ND@G supported bimetallic active site X1Y1 bimetallic atomic site catalyst and its preparation method and application, belong to the field of heterogeneous catalysis technology.The catalyst uses nanodiamond / graphene composite material as carbon carrier, constructs Ni3N active structure on its surface, and introduces X1Y1 bimetallic active site by two different noble metal (Pt, Pd, Rh, Ir, Ru) atom by step pH control strategy.The preparation key is: first, make X1 atom replace part of nickel site on the surface of Ni3N at lower pH, activate its adjacent nickel site;Subsequently, Y1 atom is preferentially replaced at the adjacent nickel site of X1 atom at higher pH, thereby forming adjacent distribution bimetallic active site X1Y1.The catalyst is particularly suitable for 2,6-diamino-3,5-dinitropyridine (DADNP) selective hydrogenation reaction to prepare 2,3,5,6-tetraaminopyridine (TAP), which can achieve high conversion and high selectivity under mild conditions.

This invention belongs to the field of organic polymer material preparation, specifically relating to the one-step synthesis of fluorinated functional ionic polymer materials and their applications. This invention provides a one-step synthesis of fluorinated functional ionic polymer materials, composed of the following raw materials: linker A as a polymer linker arm, functional monomers B and C as functional groups; wherein linker A is a fluorinated dibromide, functional monomer B is 4-aminopyridine or N,N-dimethylethylenediamine, and functional monomer C is 4,4′-methylenebis(phenyl isocyanate) or triphenylmethane triisocyanate. This invention prepares fluorinated functional ionic polymer materials in one step via a simple solvothermal method through a three-component reaction, utilizing changes in functional monomers to regulate the structure and function of the polymer material, achieving efficient removal of PFAS from water.

This invention discloses a method for preparing a low-residue styrene-maleic anhydride copolymer resin, belonging to the field of polymer synthesis technology. The preparation method includes: dissolving styrene monomer, maleic anhydride monomer, and a bifunctional trithiocarbonate RAFT reagent in an organic solvent, and then performing RAFT controlled free radical polymerization via thermal or photoinitiation. The R group of the RAFT reagent contains a 4-dimethylaminopyridine structure, which directionally enriches maleic anhydride monomer around the polymerization active center through dynamic hydrogen bonding-ion pairing, forcibly forming an alternating copolymer structure; its Z group contains a substituted cyclohexyl peroxyketal structure, which can decompose in situ under thermal or photo-triggered conditions to generate initiating free radicals without the need for an external initiator. This method achieves precise control of the copolymer's molecular weight and sequence structure, resulting in a resin with low free reagent and monomer residues, controllable number-average molecular weight, and a small molecular weight distribution coefficient.

The application belongs to the technical field of biological medicine, and particularly relates to an N,N-dimethylethylene diamine-thiodiglycolic acid monocholesteryl ester conjugate as well as a preparation method and application thereof. The structural formula of the N,N-dimethylethylene diamine-thiodiglycolic acid monocholesteryl ester conjugate is as follows: first, cholesteryl and thiodiglycolic anhydride are dissolved together, N,N-dimethylaminopyridine is added, and a reflux reaction is performed to obtain thiodiglycolic acid monocholesteryl ester; then, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride is dissolved together, N,N-dimethylethylene diamine is added, and a reaction is performed to obtain a conjugate molecule. The conjugate is blended with lecithin to serve as a cationic liposome. By adjusting the ratio of lecithin and the conjugate, the particle size and potential of the cationic liposome can be adjusted.

The present invention discloses a continuous process for amination of aminopyridines. Particularly, the invention provides a two-step or multi-step process comprising a first continuous nitration step followed by a continuous hydrogenation step to introduce an amino group to an 2-aminopyridine in meta position. Such diaminopyridine compounds are valuable starting materials in the manufacture of active pharmaceutical ingredients.

The application belongs to the field of medicine and pesticide intermediate synthesis, and particularly relates to a synthesis method of 3-amino-2-pyridine carboxylic acid. The method comprises the following steps: S1, reacting diethyl malonate and sodium hydride to obtain a sodium salt, and then reacting the sodium salt with 2,6-dichloro-3-nitropyridine to obtain 2-(6-chloro-3-nitropyridine-2-yl) malonic acid 1,3-diethyl ester; S2, reacting 2-(6-chloro-3-nitropyridine-2-yl) malonic acid 1,3-diethyl ester in the presence of a solvent and an oxidizing agent to obtain 6-chloro-3-nitro-2-pyridine carboxylic acid; and S3, hydrogen reduction of 6-chloro-3-nitro-2-pyridine carboxylic acid to obtain 3-amino-2-pyridine carboxylic acid. The process route is simple, easy to control, the raw materials are widely available, the yield is high, the cost is low, and the method is suitable for large-scale production, and has a good application prospect in the pharmaceutical industry, synthetic chemistry and medicinal chemistry.

The application discloses a photo-thermal dual-curing resin based on pyromellitic dianhydride and cinnamyl alcohol, which is composed of 4-6 parts of bio-based cinnamyl alcohol, 5-9 parts of hydroxyethyl methacrylate, 4-6 parts of pyromellitic dianhydride, 4-6.5 parts of bio-based epoxy soybean oil, 0.04-0.07 parts of a first catalyst, 0.07-0.09 parts of a polymerization inhibitor, 0.1-0.2 parts of a second catalyst and 0.4-0.7 parts of a photoinitiator in terms of weight parts; the first catalyst is at least one selected from 4-dimethylaminopyridine, p-toluenesulfonic acid, triethylamine and stannous octoate; and the second catalyst is triphenylphosphine. By introducing a rigid benzene ring structure (from PMDA) and multiple photosensitive groups (acrylate double bonds and cinnamyl double bonds), the application effectively solves the problems of low mechanical strength and poor thermal stability of a cured product of pure epoxy soybean oil-based resin. The obtained resin has excellent thermal performance, mechanical strength and high bio-based content.

This application discloses a demulsifier and its preparation method, belonging to the field of demulsifier technology. The preparation method of the demulsifier includes: adding ferric chloride hexahydrate, sodium acetate, and polyethylene glycol to a polyol solvent, mixing them evenly at 60-80℃, then adding bentonite and ultrasonically dispersing for 20-40 min, reacting at 180-250℃ for 20-30 h, washing, and drying; ultrasonically dispersing the obtained magnetic bentonite in an organic solvent for 15-30 min, adding a silane coupling agent, stirring at 70-85℃ for 6-10 h, collecting with a magnet, washing, and drying; ultrasonically dispersing the obtained silanized magnetic bentonite in an organic solvent for 15-30 min, dissolving an acrylate copolymer demulsifier and a sulfonate demulsifier in the organic solvent, adding 4-dimethylaminopyridine and ultrasonically dispersing for 10-20 min, then adding it to the silanized magnetic bentonite solution, stirring at 85-110℃ for 4-6 h, collecting with a magnet, washing, and drying to obtain the demulsifier. This demulsifier is safe, environmentally friendly, and can be repeatedly and efficiently used to achieve demulsification.

The application discloses a preparation method of 2-methyl-3-nitro-4-hydroxypyridine, which comprises the following steps: taking 2-chloro-4-amino pyridine as raw material, and first reacting with mixed acid to obtain an intermediate 2-chloro-3-nitro-4-amino pyridine; the obtained intermediate is first reacted with dimethyl / ethyl malonate to obtain dimethyl / ethyl 2-(4-amino-3-nitro pyridine-2-yl) malonate, and then the dimethyl / ethyl 2-(4-amino-3-nitro pyridine-2-yl) malonate is subjected to a hydrolysis reaction to obtain an intermediate 2-methyl-3-nitro-4-amino pyridine; and the intermediate 2-methyl-3-nitro-4-amino pyridine is subjected to diazotization and hydrolysis reactions to obtain 2-methyl-3-nitro-4-hydroxypyridine. The target product is obtained by adopting a three-step method, raw materials are cheap and easy to obtain, the process is simple and easy to operate, the cost is low, the product has high yield and purity, the method is suitable for large-scale production, and has a wide application prospect.

The present disclosure relates to a crystalline form of a fumarate salt of a diaminocyclopentyl-substituted heteroaryl derivative and uses thereof. In particular, the present disclosure provides a crystalline form A of a fumarate salt of 1-(6-{[(1S,3S)-3-(6,7-dihydro[1,4]dioxino[3,2-d]pyrimidin-2-ylamino)cyclopentyl]amino}pyridin-3-yl)-1,2-dihydropyridin-2-one and a preparation method thereof, which has good stability and can be better used for clinical treatment.

This invention discloses a 2-phenylimidazo[1,2-] α This paper describes pyridine compounds, their preparation methods, and applications, belonging to the field of pharmaceutical technology. These compounds use imidazo[1,2-α]pyridine as the core skeleton and are prepared via a three-step method: first, cyclization of 2-aminopyridine with hydroxyacetophenone yields intermediate LT1-6; then, etherification with a brominated carboxylic acid ester yields LT7-48; finally, hydroxylamine hydrolysis converts them into the target product HDDI1-42, which contains an isohydroxamic acid group. Activity tests show that these compounds possess significant HDAC1 inhibitory activity and anti-tumor cell proliferation activity.

This invention discloses a low-temperature resistant high-elasticity rubber powder for asphalt and its preparation method, belonging to the technical field of rubber powder. Polyethylene glycol, 2,2,6,6-tetramethylpiperidine-1-oxy radical, sodium bromide, and sodium hypochlorite react to obtain carboxyl-terminated polyethylene glycol; the carboxyl-terminated polyethylene glycol and α-cyclodextrin are mixed and then reacted with adamantane, Carter's condensing agent, and N,N-diisopropylethylamine to obtain cyclodextrin-based polyrotaxane; the cyclodextrin-based polyrotaxane, sodium hydroxide, and 2,3-epoxypropyltrimethylammonium chloride react to obtain cationic cyclodextrin polyrotaxane; the cationic cyclodextrin polyrotaxane, lipoic acid, N,N'-dicyclohexylcarbodiimide, and 4-dimethylaminopyridine react to obtain disulfide-bonded polyrotaxane; the disulfide-bonded polyrotaxane is mixed and stirred with anhydrous ethanol and deionized water to obtain a modified polyrotaxane dispersion; waste rubber powder and the modified polyrotaxane dispersion are mixed and stirred to obtain high-elasticity rubber powder for asphalt.

The application provides a diluent for high-temperature and high-density drilling fluid and a preparation method thereof, and the preparation method comprises the following steps: S1, mixing monomers, a chain transfer agent and a solvent, stirring and dissolving, then introducing N2 to remove oxygen, then adding an initiator to perform a polymerization reaction, cooling to room temperature after the reaction is completed, and obtaining a first mixed solution; S2, adding 3,4-dihydroxybenzaldehyde and p-toluenesulfonic acid to the first mixed solution, introducing N2 to remove oxygen, then performing a reaction at a first temperature, cooling to room temperature after the reaction is completed, and obtaining a second mixed solution; S3, adding 3-chloro-2-hydroxypropanesulfonic acid sodium and 4-dimethylaminopyridine to the second mixed solution, introducing N2 to remove oxygen, then performing a reaction at a second temperature, cooling to room temperature after the reaction is completed, then freezing and recrystallizing, and obtaining the powder-shaped diluent; the prepared diluent can adjust the rheological property of the drilling fluid at high temperature and maintain various performances of the drilling fluid.

This invention discloses a fluoroquinazolinone compound, its preparation method, and its applications, belonging to the fields of organic synthetic chemistry and agricultural fungicide technology. The method uses 2-((2-(trifluoromethyl)quinazolin-4-yl)oxy)acetic acid and oxime ether compounds as raw materials. Under the action of the condensing agent 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and the catalyst 4-dimethylaminopyridine, the reaction is carried out at 20-30℃ for 8-16 h to construct a target compound in one step, fusing multiple active fragments including quinazolinone, trifluoromethyl, oxime ether, and amide. This invention features mild reaction conditions, simple operation, good functional group compatibility, a wide range of substrate applicability, and good product yield. The eight compounds prepared all exhibit certain fungicidal activity against *Rhizoctonia solani*, *Tricholoma mater*, and *Rhizoctonia solani*. Compound 3d showed an inhibition rate of up to 90.7% against *Tricholoma mater*, providing important lead compounds and new synthetic ideas for the development of novel green agricultural fungicides.

Aminopyridinyl-imidazo[4,5-b]pyridine compounds and related compounds, pharmaceutical compositions, and their use in the treatment of diseases such as cancer.

Provided are compounds of the Formula I, and salts, hydrates and solvates thereof:wherein R1, V1, RN and Q1 are each as defined in the specification. The compounds are inhibitors of EGFR, including mutated forms of EGFR (for example EGFR comprising a T790M mutation, a deletion in exon 19 (e.g. A740-A750), an exon 20 insertion, a mutation at L858R and / or a C797S mutation) that confer resistance to existing EGFR inhibitors.

This invention discloses a method for synthesizing an intermediate of isopropylpyridine, using 3-bromo-4-isopropylaniline as the starting material, and obtaining 2-bromo-4-chloroisopropylbenzene through deamination and chlorination under the action of nitric acid, triphosgene, and a base; wherein the base is 4-pyrrolylpyridine, 4-dimethylaminopyridine, pyridine, etc. The synthesis method of this invention uses inexpensive and readily available starting materials and reagents, resulting in low production costs. Furthermore, the reaction operation is simple, safe, and exhibits good selectivity with few side reactions. In particular, by optimizing the type of base, a reaction yield of at least 80%, or even 90%, and a product purity of at least 90%, or even 95%, can be obtained, making it suitable for large-scale industrial production.

This invention discloses a method for synthesizing methyl 4-aminopyridine-2-carboxylate, comprising the following steps: a) reacting compound 3 with an alkaline reagent and an oxidizing agent to obtain compound 4; b) reacting compound 4 with a solvent and a dehydrating agent to obtain methyl 4-aminopyridine-2-carboxylate. The method of this invention features simple post-processing, low purification difficulty, and convenient operation procedures, thereby improving synthesis efficiency, reducing production costs, and yielding a product with high purity, suitable for commercial production.

The invention discloses a preparation method of a coordination polymer containing CuII and research on the inhibition effect of the coordination polymer on soil urease and nitrifying bacteria, and relates to the technical field of fertilizer.The preparation method comprises the steps that 3-aminopyridine and fumaric acid serve as raw materials to synthesize N1, N4-bis (3-pyridyl)-2-butenamide, then CuCl2. 2H2O and the synthesized N1, N4-bis (3-pyridyl)-2-butenamide are used for preparing the coordination polymer containing CuII. The novel coordination polymer [Cu (3-bbpa) (5-HIPA). H2O] is synthesized from N, N, N, N ', N'-bis (3-pyridyl)-2-butenamide and 5-hydroxyisophthalic acid by a hydrothermal method, and the crystal structure of the novel coordination polymer [Cu (3-bbpa) (5-HIPA). H2O] is analyzed to research the influence of the novel coordination polymer as an inhibitor on soil urease and nitrifying bacteria. The difunctional inhibitor is studied to delay the conversion process of urea from urea nitrogen to ammonium nitrogen and ammonium nitrogen to nitrate nitrogen, overcomes the defect of single inhibition capability of a traditional inhibitor, is strong in inhibition capability, low in toxicity, low in cost and simple in synthesis method, can effectively improve the utilization rate and stability of the fertilizer urea, and has a wide application prospect. Nitrogen loss in agricultural activities is reduced, the fertilization cost is reduced, and the grain yield is increased.

This invention belongs to the field of liquid crystal display packaging electronic materials technology, specifically relating to an adhesive for LCD displays and its preparation method. The invention provides a method for preparing an adhesive for LCD displays, comprising the following steps: S1, first preparing product A using 2-allylphenol and dicyclopentadiene as raw materials, then preparing product B using product A and epichlorohydrin as raw materials, and finally subjecting product B to an esterification reaction to obtain a modified epoxy acrylate resin; S2, adding the modified epoxy acrylate resin, epoxy resin, inorganic filler, curing agent, 4-dimethylaminopyridine, and coupling agent to a solvent, mixing and stirring until homogeneous, and degassing to obtain the adhesive for LCD displays. This invention can effectively improve the glass transition temperature of the material while achieving good hardness, expanding its application scenarios in LCD displays.