The invention discloses an electrochemical synthetic method of a 3-
bromine-2-phenyl-imidazo-[1,2-alpha]
pyridine derivative. According to the method, a 2-bromoacetophenone compound and a 2-aminopyridine compound are added into DMSO containing an
ammonium perchlorate electrolyte, a
platinum sheet is served as the
cathode, a
platinum wire is served as an
anode, stirring is performed at the
room temperature, a constant-current reaction is performed, after the reaction is ended, reaction fluid is subjected to extraction, concentration and separation, and the 3-
bromine-2-phenyl-imidazo-[1,2-alpha]
pyridine derivative is obtained.
Electricity is utilized to promote the reaction, an expensive
metal catalyst is not needed, other oxidizing agents are not needed, heating is also not needed, the reaction can be performed at a mild
room temperature, selectivity is good, and the whole process is simple and easy to perform and is consistent with the concept of
green chemistry. An extra
bromine source is not needed, extra oxidizing agents are also not needed, the electrochemical synthetic method is simple, efficient and wide in substrate application, and compounds with different
substituent effect base groups can all achieve high yields.