Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof

A technology of hydrogen sulfide and water for injection, which is applied in the direction of pharmaceutical formulations, active ingredients of heterocyclic compounds, non-active ingredients of polymer compounds, etc., can solve problems such as uncontrollable processes, achieve good biocompatibility, mild reaction conditions, and easy preparation The effect of simple method

Inactive Publication Date: 2019-04-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Researchers are trying to use hydrogen sulfide donors to release hydrogen sulfide in organisms. Commonly used hydrogen sulfide donors include sodium hydrogen sulf

Method used

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  • Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof
  • Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof
  • Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof

Examples

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Embodiment 1

[0040] Taking the degree of oxidation as 50% and the ratio of 2-aminopyridine-5-thiocarboxamide as 10% as an example, the preparation of alginate-based injectable hydrogel that can release hydrogen sulfide is illustrated.

[0041] Weigh 5.0 g of sodium alginate and add it to 25 ml of absolute ethanol, and stir until it is evenly dispersed. Weigh 2.67g of sodium periodate, add it to 25ml of deionized water, and stir until completely dissolved in the dark (sodium periodate is easy to decompose when exposed to light, so it needs to be stirred in the dark, and the reaction should be carried out in the dark). Pour sodium periodate into the suspension of sodium alginate and react at room temperature for 4 hours. After 4h, 5ml of ethylene glycol was added to terminate the reaction for 15min. Pour the reaction solution into a dialysis bag, and perform dialysis with deionized water for three days, and change the dialysis water every day, about 3-4 times a day. The dialysis-completed pr...

Embodiment 2

[0045] Taking the degree of oxidation of sodium alginate as 50% and the ratio of 2-aminopyridine-5-thiocarboxamide as 20% as an example, the preparation of alginate-based injectable hydrogel that can release hydrogen sulfide is illustrated.

[0046] Weigh 5.0 g of sodium alginate and add it to 25 ml of absolute ethanol, and stir until it is evenly dispersed. Weigh 2.67g of sodium periodate, add it to 25ml of deionized water, and stir until completely dissolved in the dark (sodium periodate is easy to decompose when exposed to light, so it needs to be stirred in the dark, and the reaction should be carried out in the dark). Pour sodium periodate into the suspension of sodium alginate and react at room temperature for 4 hours. After 4h, 5ml of ethylene glycol was added to terminate the reaction for 15min. Pour the reaction solution into a dialysis bag, and perform dialysis with deionized water for three days, and change the dialysis water every day, about 3-4 times a day. The ...

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Abstract

The invention provides an injectable hydrogel capable of releasing hydrogen sulfide, and a preparation method thereof. The preparation method comprises: oxidizing the hydroxyl group on sodium alginate(ALG) into an aldehyde group to obtain partially-oxidized sodium alginate (ADA), grafting 2-aminopyridine-5-thiocarboxamide (APTA) on the partially-oxidized sodium alginate by carrying out an amino reaction on the aldehyde group and the 2-aminopyridine-5-thiocarboxamide (APTA) to obtain an aldehyde group-containing macromolecular cross-linking agent partially-oxidized sodium alginate-2-aminopyridine-5-thiocarboxamide (ADA-APTA) capable of releasing hydrogen sulfide, and blending the ADA-APTA and gelatin to obtain the alginate-based injectable hydrogel capable of releasing hydrogen sulfide. According to the present invention, the preparation method is simple, the reaction condition is mild, the biocompatibility is good, and the hydrogen sulfide release amount of the gel can be adjusted bycontrolling the grafting ratio of 2-aminopyridine-5-thiocarboxamide.

Description

technical field [0001] The invention relates to the field of biomedical materials, more specifically to the preparation of a hydrogen sulfide-releasing, alginate-based injectable hydrogel, which utilizes the reaction of the aldehyde group on the partially oxidized sodium alginate and the amino group on the gelatin Method to generate schiff bases to produce hydrogen sulfide-releasing hydrogels. Background technique [0002] Sodium alginate is a by-product of extracting iodine and mannitol from brown algae kelp or sargassum, and its molecules are composed of β-D-mannuronic acid (β-D-mannuronic, M) and α-L-gulo Uronic acid (α-L-guluronic, G) is formed by linking (1 → 4) bonds. Sodium alginate contains a large amount of -COO-, which can exhibit polyanion behavior in aqueous solution and has certain adhesion, and can be used as a drug carrier for treating mucosal tissues. [0003] Under acidic conditions, -COO- transforms into -COOH, the degree of ionization decreases, the hydr...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L89/00C08L5/04C08B37/04A61K9/06A61K31/44A61P39/00
CPCA61K9/0019A61K9/0024A61K9/06A61K31/44A61K47/42C08B37/0084C08J3/075C08J2389/00C08J2405/04
Inventor 王玮梁薇刘文广谭宝玉
Owner TIANJIN UNIV
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