Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof

A technology of hydrogen sulfide and water for injection, which is applied in the direction of pharmaceutical formulations, active ingredients of heterocyclic compounds, non-active ingredients of polymer compounds, etc., can solve problems such as uncontrollable processes, achieve good biocompatibility, mild reaction conditions, and easy preparation The effect of simple method
CN109666151AInactive Publication Date: 2019-04-23TIANJIN UNIV
2 Cites 9 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2019-04-23
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides an injectable hydrogel capable of releasing hydrogen sulfide, and a preparation method thereof. The preparation method comprises: oxidizing the hydroxyl group on sodium alginate(ALG) into an aldehyde group to obtain partially-oxidized sodium alginate (ADA), grafting 2-aminopyridine-5-thiocarboxamide (APTA) on the partially-oxidized sodium alginate by carrying out an amino reaction on the aldehyde group and the 2-aminopyridine-5-thiocarboxamide (APTA) to obtain an aldehyde group-containing macromolecular cross-linking agent partially-oxidized sodium alginate-2-aminopyridine-5-thiocarboxamide (ADA-APTA) capable of releasing hydrogen sulfide, and blending the ADA-APTA and gelatin to obtain the alginate-based injectable hydrogel capable of releasing hydrogen sulfide. According to the present invention, the preparation method is simple, the reaction condition is mild, the biocompatibility is good, and the hydrogen sulfide release amount of the gel can be adjusted bycontrolling the grafting ratio of 2-aminopyridine-5-thiocarboxamide.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of biomedical materials, more specifically to the preparation of a hydrogen sulfide-releasing, alginate-based injectable hydrogel, which utilizes the reaction of the aldehyde group on the partially oxidized sodium alginate and the amino group on the gelatin Method to generate schiff bases to produce hydrogen sulfide-releasing hydrogels. Background technique

[0002] Sodium alginate is a by-product of extracting iodine and mannitol from brown algae kelp or sargassum, and its molecules are composed of β-D-mannuronic acid (β-D-mannuronic, M) and α-L-gulo Uronic acid (α-L-guluronic, G) is formed by linking (1 → 4) bonds. Sodium alginate contains a large amount of -COO-, which can exhibit polyanion behavior in aqueous solution and has certain adhesion, and can be used as a drug carrier for treating mucosal tissues.

[0003] Under acidic conditions, -COO- transforms into -COOH, the degree of ionization decreases, the hydr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More