Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof

A technology of hydrogen sulfide and water for injection, which is applied in the direction of pharmaceutical formulations, active ingredients of heterocyclic compounds, non-active ingredients of polymer compounds, etc., can solve problems such as uncontrollable processes, achieve good biocompatibility, mild reaction conditions, and easy preparation The effect of simple method

Inactive Publication Date: 2019-04-23
TIANJIN UNIV
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Researchers are trying to use hydrogen sulfide donors to release hydrogen sulfide in organisms. Commonly used hydrogen sulfide donors include sodium hydrogen sulfide, etc., but these small molecular hydrogen sulfide donors can only release hydrogen sulfide quickly in a short period of time, and the process is impossible. control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof
  • Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof
  • Injectable hydrogel capable of releasing hydrogen sulfide, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Taking the degree of oxidation as 50% and the ratio of 2-aminopyridine-5-thiocarboxamide as 10% as an example, the preparation of alginate-based injectable hydrogel that can release hydrogen sulfide is illustrated.

[0041] Weigh 5.0 g of sodium alginate and add it to 25 ml of absolute ethanol, and stir until it is evenly dispersed. Weigh 2.67g of sodium periodate, add it to 25ml of deionized water, and stir until completely dissolved in the dark (sodium periodate is easy to decompose when exposed to light, so it needs to be stirred in the dark, and the reaction should be carried out in the dark). Pour sodium periodate into the suspension of sodium alginate and react at room temperature for 4 hours. After 4h, 5ml of ethylene glycol was added to terminate the reaction for 15min. Pour the reaction solution into a dialysis bag, and perform dialysis with deionized water for three days, and change the dialysis water every day, about 3-4 times a day. The dialysis-completed pr...

Embodiment 2

[0045] Taking the degree of oxidation of sodium alginate as 50% and the ratio of 2-aminopyridine-5-thiocarboxamide as 20% as an example, the preparation of alginate-based injectable hydrogel that can release hydrogen sulfide is illustrated.

[0046] Weigh 5.0 g of sodium alginate and add it to 25 ml of absolute ethanol, and stir until it is evenly dispersed. Weigh 2.67g of sodium periodate, add it to 25ml of deionized water, and stir until completely dissolved in the dark (sodium periodate is easy to decompose when exposed to light, so it needs to be stirred in the dark, and the reaction should be carried out in the dark). Pour sodium periodate into the suspension of sodium alginate and react at room temperature for 4 hours. After 4h, 5ml of ethylene glycol was added to terminate the reaction for 15min. Pour the reaction solution into a dialysis bag, and perform dialysis with deionized water for three days, and change the dialysis water every day, about 3-4 times a day. The ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an injectable hydrogel capable of releasing hydrogen sulfide, and a preparation method thereof. The preparation method comprises: oxidizing the hydroxyl group on sodium alginate(ALG) into an aldehyde group to obtain partially-oxidized sodium alginate (ADA), grafting 2-aminopyridine-5-thiocarboxamide (APTA) on the partially-oxidized sodium alginate by carrying out an amino reaction on the aldehyde group and the 2-aminopyridine-5-thiocarboxamide (APTA) to obtain an aldehyde group-containing macromolecular cross-linking agent partially-oxidized sodium alginate-2-aminopyridine-5-thiocarboxamide (ADA-APTA) capable of releasing hydrogen sulfide, and blending the ADA-APTA and gelatin to obtain the alginate-based injectable hydrogel capable of releasing hydrogen sulfide. According to the present invention, the preparation method is simple, the reaction condition is mild, the biocompatibility is good, and the hydrogen sulfide release amount of the gel can be adjusted bycontrolling the grafting ratio of 2-aminopyridine-5-thiocarboxamide.

Description

technical field [0001] The invention relates to the field of biomedical materials, more specifically to the preparation of a hydrogen sulfide-releasing, alginate-based injectable hydrogel, which utilizes the reaction of the aldehyde group on the partially oxidized sodium alginate and the amino group on the gelatin Method to generate schiff bases to produce hydrogen sulfide-releasing hydrogels. Background technique [0002] Sodium alginate is a by-product of extracting iodine and mannitol from brown algae kelp or sargassum, and its molecules are composed of β-D-mannuronic acid (β-D-mannuronic, M) and α-L-gulo Uronic acid (α-L-guluronic, G) is formed by linking (1 → 4) bonds. Sodium alginate contains a large amount of -COO-, which can exhibit polyanion behavior in aqueous solution and has certain adhesion, and can be used as a drug carrier for treating mucosal tissues. [0003] Under acidic conditions, -COO- transforms into -COOH, the degree of ionization decreases, the hydr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J3/075C08L89/00C08L5/04C08B37/04A61K9/06A61K31/44A61P39/00
CPCA61K9/0019A61K9/0024A61K9/06A61K31/44A61K47/42C08B37/0084C08J3/075C08J2389/00C08J2405/04
Inventor 王玮梁薇刘文广谭宝玉
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com