Method for preparing 2-aminopyridine and alkyl derivative
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG UNIV
- Publication Date
- 2004-10-27
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to a preparation method of 2-aminopyridine, an intermediate of medicine, pesticide and dye, and its alkyl derivative. Background technique
[0002] 2-Aminopyridine and its alkyl derivatives (formula I) are important medicine, pesticide and dye intermediates, and are applied in many aspects. Currently reported synthetic methods mainly contain the following:
[0003]
[0004] Where: R 1 ,R 2 ,R 3 ,R 4 stands for H, CH 3 or CH 2 CH 3 .
[0005] 1. Obtained by directly reacting pyridine or its alkyl derivatives with sodium amide. Since the ammonification reaction with sodium amide must have 2-, 4-, and 6-position isomers, the product is difficult to purify and the yield is low;
[0006] 2. It is obtained by Chichibabin's amination reaction of pyridine or its alkyl derivatives. The reagents used in this method are rare, the reaction conditions are also relatively harsh, and the yield is not high;...