7results about How to "Small weight difference" patented technology

The forming device comprises a first rotating disc, lower punching die heads capable of sliding up and down are arranged on the first rotating disc in a circumferential array mode, a convex disc with a lower opening is arranged below the first rotating disc, the convex disc with the lower opening is in an unclosed notch ring shape, and a second rotating disc is arranged above the first rotating disc. Upper punching die heads capable of sliding up and down are arranged on the second rotating disc in a circumferential array mode, a top protruding disc is arranged above the second rotating disc, and the upper ends of the upper punching die heads make sliding contact with the lower wall of the top protruding disc; the lower end of the lower punching die head is in sliding contact with the annular upper wall defined by the lower opening convex disc and the vibration ladder block. The vibration ladder block can drive the lower punching die head to vibrate in a reciprocating mode, so that materials in the lower punching die head are denser, bubbles in powder in the lower punching die head are promoted to be separated, and the weight difference between tablets is reduced.

The invention discloses a preparation method of a composition containing uridine and application thereof in treating developmental epileptic encephalopathy type 50, belonging to the technical field of pharmaceutical compositions. The preparation method comprises the following steps: preparing a disintegrant, preparing a uridine complex, preparing a tablet core, preparing a coating liquid, and coating; the preparation of the disintegrant comprises the following steps: preparing an aqueous phase, preparing an oil phase, cross-linking, primary modification, and secondary modification; the preparation of the uridine complex comprises the following steps: surface treatment and loading; the preparation of the tablet core comprises uniformly mixing the uridine complex, the disintegrant, hydroxypropyl methylcellulose, and magnesium stearate, and then tabletting to obtain the tablet core; the uridine-containing composition prepared by the invention has small weight difference and high hardness, is not easy to peel off the coating during preparation, storage, and transportation, is not easy to break and deform during preparation and transportation, and has a fast disintegration speed.

The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable adjuvant, wherein, the diameter of the micro tablet is 1 ~ 3mm, the ratio of diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor palatability of cholic acid drugs, improve medication compliance;It can realize the effect of consistent dissolution characteristics of different doses, ensure the stability of treatment effect under different doses;It can reduce the use of adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High bioavailability, can more effectively realize in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.

The application discloses a multi-form multi-functional quilt, which comprises a quilt body, wherein the quilt body is provided with a main body part and first and second subparts extending from the main body part to the same direction, the first and second subparts are separated, and the first and second subparts are connected through quick-release connecting pieces; the multi-functional quilt is provided with a first form and a second form, wherein the first form is a flat quilt, and the second form is a cape quilt. When the multi-functional quilt is used as the cape quilt, the separated first and second subparts cover the user from the left and right sides to the front of the chest, so that the quilt weight difference between the front and back of the user is small, and the user is easy to keep balance and not easy to slide down.

This invention provides a method for preparing norfloxacin capsules. By weight percentage, the capsule contents are 35%-45% norfloxacin and 55%-65% starch. The preparation method includes steps such as excipient pretreatment, premixing, wet granulation, drying, sizing, and filling. The prepared norfloxacin capsules have small weight differences, high and stable dissolution, and stable quality even after 6 months of accelerated storage.

The invention discloses a preparation method of bismuth potassium citrate tablets through dry granulation and tabletting, and belongs to the technical field of pharmaceutical preparations. The preparation method of the bismuth potassium citrate tablet comprises the following steps: uniformly mixing bismuth potassium citrate with a diluent, a disintegrating agent, an adhesive, a lubricant and the like, putting the mixture into a dry type granulator, adjusting the process parameters of the dry type granulator, extruding the mixture into a blank tablet, and carrying out granule finishing and screening, so as to obtain the bismuth potassium citrate tablet. And uniformly mixing the whole granules with additional auxiliary materials, tabletting and coating to obtain the bismuth potassium citrate tablets. Bismuth potassium citrate particles obtained through a dry granulation process are uniform in particle size, good in fluidity and good in compressibility, then the disintegration property and the dissolution rate of the product are improved to a great extent, the amplification effect is low when the process is put into production, the intra-batch and inter-batch difference of the product is small, and the process is stable and good in reproducibility.

The present application relates to a nicotine pellet composition, a nicotine pellet pouch and a preparation method thereof. The nicotine pellet composition comprises nicotine, a blank pellet core, a binder, a sweetener, a pH regulator, cellulose and cellulose derivatives, a high-molecular coating material, a lubricant, a flavoring agent and a solvent. The blank pellet core is loaded with the nicotine, and the high-molecular coating material forms a single layer or multiple layers of drug loading or coating on the blank pellet core. When the high-molecular coating material forms multiple layers of drug loading or coating, it comprises, from inside to outside, a separation layer, a drug-containing layer, a protective layer and a drug-loading layer. The present application provides a nicotine pellet composition and a nicotine pellet pouch with good fluidity, stable nicotine release and stable aroma release, which can be used for the treatment of smoking cessation or nicotine dependence.