3results about How to "Small weight difference" patented technology

The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable adjuvant, wherein, the diameter of the micro tablet is 1 ~ 3mm, the ratio of diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor palatability of cholic acid drugs, improve medication compliance;It can realize the effect of consistent dissolution characteristics of different doses, ensure the stability of treatment effect under different doses;It can reduce the use of adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High bioavailability, can more effectively realize in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.

This invention provides a method for preparing norfloxacin capsules. By weight percentage, the capsule contents are 35%-45% norfloxacin and 55%-65% starch. The preparation method includes steps such as excipient pretreatment, premixing, wet granulation, drying, sizing, and filling. The prepared norfloxacin capsules have small weight differences, high and stable dissolution, and stable quality even after 6 months of accelerated storage.

The present application relates to a nicotine pellet composition, a nicotine pellet pouch and a preparation method thereof. The nicotine pellet composition comprises nicotine, a blank pellet core, a binder, a sweetener, a pH regulator, cellulose and cellulose derivatives, a high-molecular coating material, a lubricant, a flavoring agent and a solvent. The blank pellet core is loaded with the nicotine, and the high-molecular coating material forms a single layer or multiple layers of drug loading or coating on the blank pellet core. When the high-molecular coating material forms multiple layers of drug loading or coating, it comprises, from inside to outside, a separation layer, a drug-containing layer, a protective layer and a drug-loading layer. The present application provides a nicotine pellet composition and a nicotine pellet pouch with good fluidity, stable nicotine release and stable aroma release, which can be used for the treatment of smoking cessation or nicotine dependence.