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Effervescence dispersible tablet

A technology for dispersible tablets and effervescent agents, applied in the field of new drug dosage forms, can solve the problems of many restrictions on developers, and achieve the effects of improving dispersibility, easy oral administration, and small dosage

Inactive Publication Date: 2008-03-12
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is detrimental to the development of new dosage forms of drugs, and developers are subject to too many restrictions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Licorice Effervescent Dispersible Tablets

[0029] Licorice extract medicine 112.5g

[0030] Citric acid 10g

[0031] Sodium bicarbonate 13g

[0032] Cross-linked polyvinylpyrrolidone (PVPP) 10g

[0033] Microcrystalline Cellulose (MCC) 20g

[0034] Ansai K 8g

[0035] Lactose 22.5g

[0036] Povidone K 30 4g

[0037] The above prescriptions are prepared respectively by the aforementioned three methods, and 1000 licorice effervescent dispersible tablets with a tablet weight of 0.2 g can be prepared.

[0038] 2. Sample dispersion uniformity detection

[0039] The testing standard for the dispersion uniformity of effervescent dispersible tablets is: take 2 effervescent dispersible tablets, put them in 100ml water at 20°C±1°C, shake for 3 minutes, they should all disintegrate and pass through the No. 2 sieve. Table 1 shows the detection results of the samples of licorice effervescent dispersible tablets.

[0040] Table 1. Experimental res...

Embodiment 2

[0043] 1. Traditional Chinese Medicine Sanhuang Effervescent Dispersible Tablets

[0044] Rhubarb 300g, berberine hydrochloride 5g, Scutellaria baicalensis extract 21g. Add 30% ethanol to rhubarb and reflux to extract three times, filter, combine the filtrates, recover ethanol and concentrate under reduced pressure to make a powder, mix berberine hydrochloride and baicalin extract evenly, and obtain 100 g of extract powder for later use.

[0045] Sanhuang extract powder 100g

[0046] Tartaric acid 30g

[0047] Sodium bicarbonate 36g

[0048] Sodium Carboxymethyl Starch (CMS-Na) 20g

[0049] Low-substituted hydroxypropyl cellulose (L-HPC) 40g

[0050] Aspartame 10g

[0051] Lactose (lactose) 28g

[0052] Mannitol 28g

[0053] Povidone K 30 8g

[0054] Above prescription is prepared respectively by aforementioned three kinds of methods, can make 1000 pieces of Sanhuang effervescent dispersible tablets of every weight 0.3g.

[0055] 2. Sample dispers...

example 3

[0060] 1. Western Medicine Famotidine Effervescent Dispersible Tablets

[0061] Famotidine 20g

[0062] Anhydrous citric acid 9g

[0063] Sodium bicarbonate 12g

[0064] Sodium Carboxymethyl Starch (CMS-Na) 7g

[0065] Low-substituted hydroxypropyl cellulose (L-HPC) 14g

[0066] Aspartame 1.2g

[0067] Dextrin 86.8g

[0068] Povidone K 30 2g

[0069] Above prescription is prepared respectively by aforementioned three kinds of methods, can make 1000 pieces of famotidine effervescent dispersible tablets of every heavy 0.15g.

[0070] 2. Sample dispersion uniformity detection

[0071] The testing standard for the dispersion uniformity of effervescent dispersible tablets is: take 2 effervescent dispersible tablets, put them in 100ml water at 20°C±1°C, shake for 3 minutes, they should all disintegrate and pass through the No. 2 sieve. Table 3 shows the test results of Famotib effervescent dispersible tablet samples.

[0072] Table 3. Experimental result...

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Abstract

The present invention relates to a new preparation of a Chinese medicine. The present invention particularly relates to a novel preparation of a drug with the effervescent tablet property and the dispersing agent property. In the effervescent dispersing tablet of the present invention, the weight ratio of each components are as following, which comprises 5 percentage to 60 percentage of effervescent agent, 3 percentage to 30 percentage of effervescing agent, 3 percentage to 30 percentage of disintegrant, 3 percentage to 30 percentage of excipient of the hydrophilic medicine, 1 percentage to 5 percentage of correctant. The effervescent dispersing tablet of the present invention is a novel preparation of the Chinese medicine, which has the effervescent tablet property and the dispersing agent property. The present medicine is a tablet, which can produce the gas in the water, which can disaggregate quickly and disperse evenly. The present invention is a novel preparation of the medicine, which can generate the gas; as a result the medicine can disaggregate more quickly. The drug loading dosage of the agent is large, which is beneficial for improving the dispersion uniformity, the dissolution and the bioavailability of the medicine. The present invention has the characteristics of convenience for oral administration and small dose. The present invention can sufficiently display the drug efficacy in order to meet the drug requirement of the patients.

Description

technical field [0001] The invention relates to a new dosage form of traditional Chinese medicine, especially a new dosage form of the medicine which has both effervescent tablet characteristics and dispersant characteristics. technical background [0002] Effervescent tablet is a dosage form of traditional Chinese medicine. It has been clearly stipulated in the 2005 edition of "Chinese Pharmacopoeia". Effervescent tablet refers to a tablet containing sodium bicarbonate and organic acid, which can produce gas when it meets water and is effervescent. It has been widely used in traditional Chinese medicine dosage forms, such as Xia Sangju Effervescent Tablets, Ginkgo Vitamin C Effervescent Tablets, Pediatric Kechuan Effervescent Tablets, Shuanghuanglian Effervescent Tablets, etc. There are more than 120 related patents alone. Dispersible tablet is a kind of western medicine form, which has been clearly stipulated in the 2005 edition of "Chinese Pharmacopoeia". Dispersible tabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K47/12A61K47/04A61K47/36A61K47/30
Inventor 王真张立群万近福
Owner YUNNAN BAIYAO GROUP
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