234results about How to "Oral convenience" patented technology

A tablet characterized by comprising 5-methyl-1-phenyl-2-(1H)-pyridone as the main ingredient and, based on the main ingredient, 10 to 50 wt. % excipient, 5 to 40 wt. % disintegrator, 1 to 10 wt. % binder, 0.5 to 5 wt. % lubricant, 2 to 6 wt. % coating basis, and 0.05 to 3 wt. % light-shielding agent, wherein the odor or bitterness of the 5-methyl-1-phenyl-2-(1H)-pyridone is masked and the light stability is improved.

The present invention relates to a new preparation of a Chinese medicine. The present invention particularly relates to a novel preparation of a drug with the effervescent tablet property and the dispersing agent property. In the effervescent dispersing tablet of the present invention, the weight ratio of each components are as following, which comprises 5 percentage to 60 percentage of effervescent agent, 3 percentage to 30 percentage of effervescing agent, 3 percentage to 30 percentage of disintegrant, 3 percentage to 30 percentage of excipient of the hydrophilic medicine, 1 percentage to 5 percentage of correctant. The effervescent dispersing tablet of the present invention is a novel preparation of the Chinese medicine, which has the effervescent tablet property and the dispersing agent property. The present medicine is a tablet, which can produce the gas in the water, which can disaggregate quickly and disperse evenly. The present invention is a novel preparation of the medicine, which can generate the gas; as a result the medicine can disaggregate more quickly. The drug loading dosage of the agent is large, which is beneficial for improving the dispersion uniformity, the dissolution and the bioavailability of the medicine. The present invention has the characteristics of convenience for oral administration and small dose. The present invention can sufficiently display the drug efficacy in order to meet the drug requirement of the patients.

The invention relates to a vitamin D calcium chewable tablet for calcium supplementation of children and a preparation method thereof. The chewable tablet consists of calcium carbonate, vitamin D3 powder, sorbitol, glucose, maltodextrin, citric acid, magnesium stearate, lemon essence and water. The preparation method comprises the following steps: (1) inspecting the necessary raw materials and additives, and separately sieving through a 100 meshes sieve for later use; (2) mixing; (3) preparing a soft material; (4) granulating and drying; (5) finishing the granules and mixing all together; and (6) measuring the moisture and a midbody content, tabletting and bottling. The vitamin D calcium chewable tablet provided by the invention can promote the absorption of calcium, can guarantee the utilization rate of calcium, is taken in a chewing way, has a fruit flavor and is convenient for oral administration of children. Since vitamin D3 is poor in stability and is easy to oxidize, vitamin D3 is added in the mixing procedure, to ensure the product stability.

The invention relates to a paraquat-containing paste agent and a preparation method thereof. The paraquat paste agent is prepared by thoroughly mixing an effective component of 10% to 50% by mass of paraquat dichloride and a proper quantity of water-soluble high polymers, a surfactant, an emetic, a filler, a moisturizing agent, a coloring agent and an olfactory warning agent. At present, the dosage form of paraquat is mainly water agent, being easily administered orally. According to the invention,the paste agent prepared from paraquat, which is not easily administered, can effectively reduce the risk of paraquat poisoning, and compared with other types of conventional preparations, the paraquat paste agent has a good environmental compatibility and an excellent weed control effect.

A Chinese medicine in the form of decoction for treating rhinitis and nasosinusitis and improving immunity and memory is prepared from 15 Chinese-medicinal materials includes astragalus root, coix seed, dandelion herb, honeysuckle flower, etc.

The invention discloses a gastroenteric motility marker capsule. The capsule comprises a hollow capsule and a content marker, wherein the component of the hollow capsule is gelatin, the hollow capsuleis filled with the content marker prepared from medical type-I barium sulfate and medical silica gel in proportion by sufficient mixing and vulcanization, and in percentage by mass, the medical type-I barium sulfate in the content marker accounts for 55%-60% and the medical silica gel accounts for 40%-55%. The gastroenteric motility marker capsule has the advantages of being non-toxic, non-irritating and convenient to orally take, has price advantages as compared with imported markers and is convenient to carry, two grains of capsule are taken three times at every 24 h after medicine taking,radiograph is taken in hospital after 72 h, and the marker capsule is time-saving, labor-saving and convenient.

The invention relates to an oridonin cubic liquid crystal nanoparticle and a preparation method thereof. The oridonin cubic liquid crystal nanoparticle is prepared from the following raw materials in percentage by weight: 0.1 to 0.5 percent of oridonin, 7 to 64 percent of amphiphilic lipid material, 6 to 29 percent of solvent, 1 to 8 percent of stabilizer, and 25 to 65 percent of water, wherein the amphiphilic lipid material is glycerol mono-oleate or phytould likeriol; the mass ratio of a liquid crystal material to the stabilizer is 1 to (0.01 to 0.30). The oridonin cubic liquid crystal nanoparticle provided by the invention is smaller in particle size, good in uniformity, and beneficial to endocytosis and transfer of enterocyte; by utilizing a unique structure of cubic liquid crystal, a dissolution barrier and a permeation barrier of the oridonin during an oral absorption process are effectively overcome, the oral relative bioavailability of the oridonin is remarkably improved, and meanwhile, the oridonin can be slowly released.

The invention discloses a recombinant bacillus subtilis EV71-VP1 expression vector, the vector is an escherichia coli-bacillus subtilis shuttle expression vector, and a coding gene of capsid protein VP1 of EV71 virus is loaded on the vector. The construction method is as follows: (1) amplifying CotB gene regulatory sequence and coding sequence of bacillus subtilis, connecting to a pMD18T vector, and obtaining plasmid pDG1662-CotB; and (2) amplifying enterovirus 71 type capsid protein VP1 antigen sequence, connecting to the plasmid pDG1662-CotB, and obtaining plasmid pDG1662-CotB-VP1 which is the recombinant bacillus subtilis EV71-VP1 expression vector. After introducing the recombinant vector into host cells for culturing, oral vaccines for preventing or treating diseases caused by EV71 can be further prepared.

The invention relates to a male health food, in particular relates to a health food for alleviating fatigue and improving male climacteric syndrome, and a method for preparing the same. Based on weight ratio, the health food comprises the following materails as active ingredients of: 500-700 American ginseng, 450-650 herba epimedii, 350-450 fructus lycii, 450-600 puncturevine, 300-460 dodder seed, 350-450 raspberry , 270-370 semen cassiae, 20-80 radix puerariae, and 5-35 vitamin e. The invention is pure natural preparation which has three functions of activating gonad, nourishing testis, and powering blood. It is simple and convenient for taking the health food, safely and effectively, without toxic and side effect, thereby, the fatigue and the male climacteric syndrome are ultimately prevented, treated and improved from interior to exterior, and uneasiness and pain of the male are reduced.

The invention provides a new L-carnitine pharmaceutically-acceptable salt, namely L-carnitine pyruvate and divalent metal salts thereof, and a preparation method and application thereof. The L-carnitine pyruvate and divalent metal salts thereof have the characteristics of higher stability and lower water absorbing tendency than the L-carnitine inner salts, can be accepted by the human body and participate in the physiologic metabolism of the human body more easily than the existing L-carnitine pharmaceutically-acceptable salts, and have stronger nutrition and treatment actions. The invention also provides application of the L-carnitine pyruvate and divalent metal salts in preparing slimming medicines or health foods, application in preparing diet/nutrition supplements and application in preparing veterinary products or feeds.

The present invention discloses one kind of soft diphyidamole capsule and its preparation process. The medicine consists of medicine liquid and capsule shell, the medicine liquid contains diphyidamole, matrix and stabilizer, and the capsule shell contains gelatin, glycerin, water, preservative and light screening agent. Compared with available diphyidamole preparations, the present invention is even suitable for children and other people incapable of taking care of himself to take and has the advantages of high bioavailability, high stability, accurate content, etc.

An orally taken Chinese medicine for treating apoplexy is prepared from astragalus root, Chinese angelica root and Chuan-xiong rhizome.

Pharmaceutical compositions comprising an extended release formulation of active compounds effective in the treatment of various pathological conditions are provided. More particularly, the invention provides methods of making and using extended release formulations comprising active compounds that present formulation challenges such as short biological half-life, instability, highly water soluble and/or high dose requirements. Specifically, orally administrable extended release pellet and tablet formulations of isovaleramide are preferred.

The invention provides a preparation process of a three-layer effervescent tablet comprising B vitamins. The method comprises the steps that: (1) a slurry of an acid source and an internally added disintegrating agent prepared by using an adhesive is prepared into granules with a wet granulation method; the granules are uniformly mixed with B vitamins, a disintegrating agent, and a lubricant, such that a first layer is prepared; (2) a material used as a separation layer is adopted as a second layer; (3) a carbon dioxide source, lactose, and an internally added disintegrating agent are subjected to wet granulation; the obtained granules are uniformly mixed with a pigment, a sweetening agent, a disintegrating agent, and a lubricant, such that a third layer is obtained; and (4) the three-layer tablet is obtained by pressing the three layers. With the process provided by the invention, the prepared product has the advantages of smooth, bright, and clean surface, uniform surface color, good effervescent effect, good stability, low expansion under high humidity, convenient carrying, and easy oral administration.

The invention provides a soft capsule for calming the nerves and nourishing the brain, which is prepared from concrete powder, suspension auxiliary agent and light-screening agent. The invention also discloses the process for preparing the soft capsule and its quality control method.

The invention discloses a process for preparing a three-layer effervescent tablet containing vitamin C. The process comprises the steps of: (1) carrying out wet-process granulation on slurry prepared from an acid source and a bonding agent for an internally added disintegrating agent to prepare particles, and uniformly mixing the particles with the vitamin C, the disintegrating agent and a lubricating agent to serve as a first layer for later use; (2) taking materials used as a middle isolation layer as a second layer for later use; (3) carrying out wet-process granulation on a carbon dioxide source, lactose and the internally added disintegrating agent to prepare particles, and uniformly mixing the particles with pigment, a sweetener, the disintegrating agent and the lubricating agent to serve as a third layer; and (4) pressing together to obtain a three-layer tablet. A product prepared according to the invention has the advantages of smooth and bright surface, uniform glossiness, good effervescent effect, favorable stability, smaller expansion under a high humidity state, convenience in carrying, and simpleness for oral administration.

The composition of Chinese medicine for curing diabetes is formed from (by weight ratio) scutellaria root 3-10, phellodendron bark 3-12, astragalus root 8-12, red ginseng 5-10, dried/fresh rehmannia root 10-18 and poria 7-14. Said invented Chinese medicine can completely regulate magnesium of human body, balance internal yin and yang, improve qi and blood distribance, recover functions of internal organs, strengthen kidney and fortify spleen and can promote islet cell to normally secrete insulin so as to obtain the goal of curing diabetes.

The invention relates to a raspberry health product and a preparation technique thereof. The raspberry health product comprises two parts of raw materials and auxiliary materials; wherein the raw materials are raspberry and American ginseng with the proportion of weight portions of usage thereof of 100:8 to 16; the auxiliary materials are a filling and shaping agent, a wetting agent and a lubricating agent. As the new formula and extracting preparation technique are adopted, the invention furthest remains all effective active components in the raw materials, guarantees bioavailability and health effect, is beneficial to oral administration and long-term storage, has simple preparation technique, short production cycle and low production cost and is an ideal and novel health product with combination of raspberry and American ginseng at present.

Disclosed is a substance capable of promoting the repair of a fractured part in a fracture caused by an external force, fatigue or a disease. Also disclosed is a method for producing the substance. Further disclosed is a product capable of promoting the repair of a fracture, such as a food, a beverage and a feed, which comprises the fracture repair promoter. Specifically disclosed is a fracture repair promoter comprising, as an active ingredient, a fraction containing a milk-derived basic protein. In the promoter, the fraction containing the milk-derived basic protein is produced by contacting milk or a milk-derived raw material with a cation exchange resin to cause the adsorption of the basic protein on the cation exchange resin and eluting a fraction adsorbed on the resin by means of an eluent having a salt concentration of 0.1 to 1.0 M.