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Dipyridamole soft capsule preparation and its preparing method

A dipyridamole, soft capsule technology, applied in capsule delivery, antiviral agents, blood diseases, etc., to achieve high bioavailability, favorable for oral administration, and improved bioavailability

Inactive Publication Date: 2005-03-02
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a dipyridamole soft capsule formulation that is safe and convenient for children and patients who cannot take care of themselves and its preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Put 1kg of gelatin, 350g of glycerin, 1kg of water, an appropriate amount of pigment, and 2.5g of ethylparaben into a chemical glue tank, then heat the mixture to about 70-80°C, mix well, vacuumize, filter, keep warm and let it stand for a while. use. Take 15g of ethyl cellulose and 276g of vegetable oil, heat and melt, then add 15g of dipyridamole in a mixer, mix well, measure the content, and set aside. After being compressed in the soft capsule manufacturing machine, the drops are set in the setting machine for finalizing the shape. After washing, the drops are dried at around 30°C for 12 hours.

[0014] According to the process of Example 1, the detailed components can be changed as follows.

Embodiment 2

[0016] Component Quantity (g)

[0017] Dipyridamole 15

[0018] beeswax 9

[0019] Vegetable oil 276

Embodiment 3

[0021] Component Quantity (g)

[0022] Dipyridamole 15

[0023] Glycerin 285

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PUM

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Abstract

The present invention discloses one kind of soft diphyidamole capsule and its preparation process. The medicine consists of medicine liquid and capsule shell, the medicine liquid contains diphyidamole, matrix and stabilizer, and the capsule shell contains gelatin, glycerin, water, preservative and light screening agent. Compared with available diphyidamole preparations, the present invention is even suitable for children and other people incapable of taking care of himself to take and has the advantages of high bioavailability, high stability, accurate content, etc.

Description

technical field [0001] The invention relates to a dipyridamole soft capsule preparation and a preparation method thereof, and belongs to the technical field of medicines and preparation thereof. technical background [0002] Dipyridamole (dipyridamole, also known as dipyridamole) is a drug that expands coronary blood vessels and resists platelet aggregation developed by West Germany Bellinger in 1961. In recent years, with the further understanding of its pharmacological effects, it has been found that dipyridamole also has: 1. Broad-spectrum antiviral effects, it can inhibit small RNA viruses, orthomyxoviruses and some DNA viruses, and can inhibit the specific proliferation of viruses Process; 2. Induce the activity of interferon, enhance the immune response, increase the body's anti-virus ability, regulate abnormal immune response and reduce immune damage. 3. Improve microcirculation and accelerate blood flow. These effects have opened up ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/519A61P7/02A61P9/10A61P11/00A61P31/12
Inventor 庄大伟孙丽红王卓睿王嘉瑜张志宏
Owner 北京瑞伊人科技发展有限公司
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