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8-amino acid/11-vitamin containing micro granule capsule and preparation method thereof

A technology of micropill capsules and vitamins, applied in capsule delivery, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., can solve problems such as product content decline, product appearance discoloration, and restrictions on the application of amino acid oral preparations

Active Publication Date: 2010-07-14
SHENZHEN WANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the instability of amino acids, the stability of amino acid oral preparations is poor, which restricts the application of amino acid oral preparations
Chinese patent CN1781486, the name of the invention is: a compound amino acid and vitamin capsule preparation and its preparation method. The formula and preparation method of this invention are different from those of the product of the present invention. After testing, it is found that the product prepared by this invention The stability is not good, at 12 months, the appearance of the product changes color obviously and the product content drops obviously
Therefore, there is a lack of a compound amino acid and vitamin product with reasonable formula and good stability in the market at present.

Method used

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  • 8-amino acid/11-vitamin containing micro granule capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] The formula of 8 kinds of amino acids and 11 kinds of vitamin pellet capsules of the present invention is: wherein thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin pellets b, amino acid pellets b, vitamin C pellets and vitamin AD The weight ratio of these seven kinds of round micropellets of microbeads is:

[0092] Thiamine nitrate pellets

6.88

Vitamin pellets a

17.1

Amino Acid Pellets a

36.8

Vitamin pellets b

10

Amino acid pellets b

7.56

Vitamin C Pellets

13.4

Vitamin AD microbeads

6.2

[0093] 1. The formula of thiamine nitrate pellets is:

[0094] Thiamine nitrate

250g

lactose

450g

starch

45g

Calcium Carboxymethyl Cellulose

75g

Methylcellulose

22g

Hydroxypropyl Cellulose

19g

Titanium dioxide

23g

microcrystalline cellulose

116g

[0095] 2. The for...

Embodiment 2

[0117] The formula of 8 kinds of amino acids of the present invention and 11 kinds of vitamin micropill capsules is:

[0118] Wherein the weight ratio of these seven round pellets of thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin pellets b, amino acid pellets b, vitamin C pellets and vitamin AD pellets is:

[0119] Thiamine nitrate pellets

2.66

Vitamin pellets a

16.35

Amino Acid Pellets a

35.0

Vitamin pellets b

11.4

Amino acid pellets b

6.65

Vitamin C Pellets

12.73

Vitamin AD microbeads

5.7

[0120] 1. The formula of thiamine nitrate pellets is:

[0121] Thiamine nitrate

76g

lactose

225g

starch

9g

[0122] Thiamine nitrate

76g

Calcium Carboxymethyl Cellulose

15g

Methylcellulose

4.4g

Hydroxypropyl Cellulose

3.8g

Titanium dioxide

4.6g

microcrystal...

Embodiment 3

[0144] The formula of 8 kinds of amino acids and 11 kinds of vitamin micropellets capsules is:

[0145] The weight ratio of these seven round pellets of thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin pellets b, amino acid pellets b, vitamin C pellets and vitamin AD pellets is:

[0146] Thiamine nitrate pellets

9.9

Vitamin pellets a

20.5

Amino Acid Pellets a

44.1

Vitamin pellets b

14.4

Amino acid pellets b

10.5

Vitamin C Pellets

16.0

Vitamin AD microbeads

9.36

[0147] 1. The formula of thiamine nitrate pellets is:

[0148] Thiamine nitrate

300g

lactose

675g

starch

81g

Calcium Carboxymethyl Cellulose

135g

Methylcellulose

39.6g

Hydroxypropyl Cellulose

34.2g

Titanium dioxide

41.4g

microcrystalline cellulose

174g

[0149] 2. The formula of vitamin micropills...

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Abstract

The invention discloses an 8-amino acid / 11-vitamin containing micro granule capsule and a preparation method thereof, wherein the micro granule capsule contains 7 ball micro granules consisting of the following raw materials in part by weight: 2.66-9.9 parts of thiamine mononitrate micro granule, 16.35-20.5 parts of vitamin micro granule a, 35.0-44.1 parts of amino acid micro granule a, 11.4-14.4 parts of vitamin micro granule b, 6.65-10.5 parts of amino acid micro granule b, 12.73-16.0 parts of vitamin C micro granule and 5.7-9.36 parts of vitamin AD micro bead. The method has the advantages of scientific and reasonable proportion, good stability of products, no toxicity and side effect and excellent biological effect, and can be used for the preparation of medicines treating chronic liver and kidney diseases and of food alleviating and eliminating physical fatigue caused by sports training.

Description

technical field [0001] The invention relates to a micropill capsule and a preparation method thereof, in particular to a micropill capsule of 8 kinds of amino acids and 11 kinds of vitamins and a preparation method thereof. Background technique [0002] Protein is the material basis of human life activities. Various physiological functions of the human body, especially immune function, cell damage repair function and growth and development function, are closely related to the normality of its metabolism. Under normal circumstances, the human body obtains various amino acids through the protein in food to ensure the normal protein metabolism of the body. Among the 20 kinds of amino acids needed for human protein synthesis, 8 kinds of amino acids are essential amino acids for the human body. These 8 kinds of amino acids cannot be synthesized by the body itself and must rely on external supply. They are isoleucine, leucine, lysine, phenylalanine, threonine, valine, methionine,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/59A61K31/525A61K31/519A61K31/51A61K31/455A61K31/4415A61K31/405A61K31/375A61K31/355A61K31/198A61K31/197A61K31/195A61K31/07A61K9/48A61P1/16A61P13/12A61P3/02
Inventor 王仲荪
Owner SHENZHEN WANHE PHARMA
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