9results about How to "Guaranteed bioavailability" patented technology

The invention discloses a self-assembled polypeptide nano-enzyme and application thereof, the self-assembled polypeptide nano-enzyme comprises a polypeptide scaffold, a polypeptide sequence with targeting and nano-enzyme affinity, a main body with amino acid having a characteristic sequence derived from natural enzyme and a functional motif containing hydrophobic peptide, the polypeptide nanoparticles are self-assembled by utilizing the hydrophobic interaction of amino acids; the nano enzyme is in coordination binding with the central coordination amino acid; and the targeting peptide is positioned at the N end of the polypeptide sequence and is displayed on the outer layer surface of the self-assembled polypeptide nanoparticle. According to the invention, the high-activity nano-enzyme is biomimetically designed by simulating a natural enzyme metal ion active site and a spatial structure of a catalytic microenvironment. The novel polypeptide nano-enzyme with targeting property and biosafety is constructed by taking polypeptide as a synthesis template. The self-assembled polypeptide nano-enzyme can be administrated through aerosol inhalation, targeted positioning of the nano-enzyme on a focus is guided, ROS of focus tissue is regulated and controlled, and occurrence and development of diseases are inhibited.

The invention discloses a ginkgo dispersible tablet with high dispersion uniformity and a processing technology. The processing technology comprises the following steps: step 1, taking materials; step 2, pretreatment; step 3, primary mixing; step 4, performing three-dimensional mixing; step five, granulating; step 6, post-processing; step 7, tabletting; step 8, coating; according to the ginkgo dispersible tablet, the high-quality ginkgo leaf extract is selected as the raw material, meanwhile, povidone is added to enhance the strength and stability of the tablet, and the granularity specification is controlled in cooperation with multiple times of sieving, so that the prepared ginkgo dispersible tablet has high dispersion uniformity, and the effectiveness and bioavailability of the medicine are guaranteed; residual particle impurities and moisture are removed through pretreatment, so that the purity of the raw materials is guaranteed, and the processing quality of the ginkgo dispersible tablets is improved; during coating treatment, polyvinyl alcohol is selected as a coating material, polyethylene glycol is added as a plasticizer, and coating is performed twice, so that the surface smoothness is improved, coating cracks are prevented, and the disintegration time limit and the dissolution rate of the dispersible tablet are guaranteed.

The invention provides the preparation method of the ezetimibe and rosuvastatin calcium composition, which ensures the long-term stability of the preparation, is simple and convenient in process and is suitable for industrial production. According to the preparation method, conventional accessible equipment is adopted for preparation, key quality attributes of intermediate products in the preparation process are strictly controlled, the prepared finished product is stable in quality in the long-term storage process, and the total degradation product is smaller than 2.5% after the finished product is stored for 36 months.

The application provides a preparation method of astaxanthin cordyceps militaris fine tablets, comprising the following steps: subjecting cordyceps militaris fruiting bodies to supercritical CO2 extraction treatment to separate a cordyceps militaris terpene component; mixing Haematococcus pluvialis powder and edible vegetable oil, adding the cordyceps militaris terpene component and rosemary extract, and cooling and forming to obtain an astaxanthin-cordyceps militaris terpene blend; crushing the residue after extraction, adding purified water and a composite enzyme preparation to perform enzymolysis to obtain an enzymolysis liquid; adding a chitosan quaternary ammonium salt solution, centrifuging after flocculation, vacuum drying, and crushing to obtain cordyceps militaris active powder; mixing and granulating raw materials to obtain granulation particles; uniformly mixing the granulation particles with xylitol and microcrystalline cellulose, and pressing into tablets; and placing the tablets in a coating machine for coating. The application realizes efficient retention of active ingredients, improvement of safety and stability of product quality through the cooperation of multiple technologies such as supercritical CO2 extraction, enzymolysis flocculation, low-temperature fluidized bed granulation and hot melt coating.

The invention relates to the field of stem cell biomedicine, and provides a preparation method of a mesenchymal stem cell factor composition in order to solve the problem that umbilical cord mesenchymal stem cells in the prior art are difficult to be used for acute insomnia symptoms, and the preparation method comprises the following steps: S100, inoculating primary umbilical cord mesenchymal stem cells into a first culture medium to obtain P1-generation mesenchymal stem cells; s200, subculturing the P1-generation mesenchymal stem cells in a second culture medium environment for 5-7 generations to obtain generations of mesenchymal stem cells; s300, subculturing the mesenchymal stem cells for 2-4 generations in a third culture medium environment to obtain a cell suspension; filtering the culture medium supernate of the P6-P7 generation mesenchymal stem cells through a filter membrane, and taking filtrate; and mixing the cell suspension with the filtrate to obtain the mesenchymal stem cell factor composition. According to the method, the culture operation of the umbilical cord mesenchymal stem cells is improved, and factors secreted in the culture period are biased to sedative factors and melatonin precursor factors, so that the supernate in the culture process has the effect of improving acute insomnia.

This invention discloses a lutein composition for relieving eye fatigue and its preparation method, belonging to the field of functional foods. The process involves: reacting phycocyanin and kelp polyphenols to obtain modified phycocyanin; reacting fucoidan and β-glucuronidase to obtain modified fucose; reacting fish collagen peptides and zinc chloride to obtain collagen peptide-zinc chelate; reacting lutein silica cage complex and modified phycocyanin to obtain a first complex; reacting the first complex and modified fucose to obtain a second complex; reacting the second complex, collagen peptide-zinc chelate, and krill oil to obtain a lutein complex; reacting the second complex, collagen peptide-zinc chelate, and krill oil, then adding trehalose to obtain the lutein complex; and finally mixing the lutein complex with maltodextrin to obtain the lutein composition.

The invention discloses a preparation method of oral antibiotic granules. The preparation method comprises the following steps: 1) treating raw materials and auxiliary materials: preparing an adhesive solution; sieving other raw and auxiliary materials; 2) granulating: adding the raw and auxiliary materials according to the prescription amount into a mixer for mixing; a one-step granulator is used, the air inlet temperature is set, the adhesive solution prepared in the step 1) is added in a top spraying mode for granulation, and the water content of granules is controlled to be 2.1% or below; (3) finishing granules: finishing the granules through a screen; (4) mixing: mixing the whole granules again; and 5) packaging: packaging according to set specifications. The oral antibiotic granules obtained by the invention have good stability and dissolution rate.

The invention relates to a preparation containing pravastatin sodium enteric-coated pellets as well as a preparation method and application thereof, and relates to the technical field of biological medicines. According to the preparation disclosed by the invention, the unification of enteric protection and patient-friendly administration is realized, and the bioavailability of the medicine and the convenience and compliance of taking the medicine are remarkably improved; according to the preparation disclosed by the invention, the structure of the enteric-coated pellet is specially designed aiming at the processing and using characteristics of the dry suspension and the orally disintegrating tablet, so that the obtained enteric-coated pellet can be stably applied to the dry suspension or the orally disintegrating tablet while being not released in the stomach, and the medicine taking convenience and compliance of old people and patients with dysphagia are remarkably improved. According to the invention, the technical contradiction that an enteric preparation is difficult to be compatible with a patient-friendly dosage form in the prior art is solved, and a pravastatin administration scheme which gives consideration to enteric protection, bioavailability improvement and ease of administration is provided for old people or patients with dysphagia.

The invention relates to a formula and a preparation process for repairing and improving ovarian aging. The preparation process comprises the following steps: S1, screening and pretreating raw materials; s2, extracting active ingredients; s3, refining and purifying the extracting solution; s4, compounding formula components; according to the formula and the preparation process for repairing and improving ovarian aging, various natural active ingredients with definite pharmacological effects are scientifically matched, and an advanced dynamic circulating countercurrent extraction technology and a multistage membrane separation and purification process are adopted; systematic intervention on ovarian aging-related oxidative stress, mitochondrial dysfunction, follicle apoptosis and other multi-dimensional pathological mechanisms is realized, and meanwhile, through strict raw material quality control, standardized preparation process and whole-process quality monitoring, the quality stability between batches of products and the bioavailability of active components are ensured.