A kind of rupatadine fumarate tablet
A technology of rupatadine fumarate and tablets, which is applied in the directions of pill delivery, medical preparations of inactive ingredients, organic active ingredients, etc., to achieve good effects, ensure bioavailability, and improve the effect of loose tablets
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Embodiment 1
[0028] The preparation of embodiment 1-tablet of the present invention
[0029] prescription:
[0030]
[0031] Preparation method:
[0032] 1. Pass rupatadine fumarate through a 100-mesh sieve, and pulverize lactose, pregelatinized starch, and hydroxypropyl cellulose through a 80-mesh sieve for later use;
[0033] 2. Take Povidone K 30 , add an appropriate amount of 85% ethanol to dissolve, and make a 10% solution for later use;
[0034] 3. Mix red iron oxide and yellow iron oxide, and mix them with appropriate amount of lactose in equal increments, then add rupatadine fumarate, pregelatinized starch, hydroxypropyl cellulose and remaining lactose, mix evenly, add 10 % povidone K 30 Appropriate amount of 85% ethanol solution is made into soft material, granulated with 20 mesh sieve, dried at 50°C-70°C, moisture is controlled at 1.0%-3.0%, and granulated with 20 mesh sieve;
[0035] 4. Add magnesium stearate and talcum powder and mix evenly, measure the particle c...
Embodiment 2
[0039] The preparation of embodiment 2-tablet of the present invention
[0040] prescription:
[0041]
[0042] Preparation method:
[0043] 1. Pass rupatadine fumarate through a 100-mesh sieve, and pulverize lactose, pregelatinized starch, and hydroxypropyl cellulose through a 80-mesh sieve for later use;
[0044] 2. Take Povidone K 30 , add an appropriate amount of 85% ethanol to dissolve, and make a 10% solution for later use;
[0045] 3. Mix red iron oxide and yellow iron oxide, and mix them with appropriate amount of lactose in equal increments, then add rupatadine fumarate, pregelatinized starch, hydroxypropyl cellulose and remaining lactose, mix evenly, add 10 % povidone K 30 Appropriate amount of 85% ethanol solution is made into soft material, granulated with 20 mesh sieve, dried at 50°C-70°C, moisture is controlled at 1.0%-3.0%, and granulated with 20 mesh sieve;
[0046] 4. Add magnesium stearate and talcum powder and mix evenly, measure the particle conten...
Embodiment 3
[0050] Embodiment 3-preparation of tablet of the present invention
[0051] prescription:
[0052]
[0053] Preparation method:
[0054] 1. Pass rupatadine fumarate through a 100-mesh sieve, and pulverize lactose, pregelatinized starch, and hydroxypropyl cellulose through a 80-mesh sieve for later use;
[0055] 2. Take Povidone K 30 , add an appropriate amount of 85% ethanol to dissolve, and make a 10% solution for later use;
[0056] 3. Mix red iron oxide and yellow iron oxide, and mix them with appropriate amount of lactose in equal increments, then add rupatadine fumarate, pregelatinized starch, hydroxypropyl cellulose and remaining lactose, mix evenly, add 10 % Povidone K 30 Appropriate amount of 85% ethanol solution is made into soft material, granulated with 20 mesh sieve, dried at 50°C-70°C, moisture is controlled at 1.0%-3.0%, and granulated with 20 mesh sieve;
[0057] 4. Add magnesium stearate and stearic acid and mix evenly, measure the particle content, an...
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