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A kind of preparation method of Ganoderma lucidum extract sheet

A technology of Ganoderma lucidum extract and thick paste, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the problems of insufficient hardness, color difference, loose flakes, etc.

Active Publication Date: 2016-04-20
JIANGXI BAISHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently commercially available Ganoderma lucidum extract tablets have defects such as poor stability, insufficient hardness, color difference, and loose flakes. After research, the present invention provides a new preparation method for Ganoderma lucidum extract tablets, improves the process conditions, and determines the types and dosage of auxiliary materials. Improve tablet quality, issues such as bioavailability and dissolution, stability

Method used

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  • A kind of preparation method of Ganoderma lucidum extract sheet
  • A kind of preparation method of Ganoderma lucidum extract sheet
  • A kind of preparation method of Ganoderma lucidum extract sheet

Examples

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Embodiment 1

[0056] A preparation method of Ganoderma lucidum extract sheet:

[0057] Wherein, the weight ratio of each raw material is: 9 parts of Ganoderma lucidum extract, 3 parts of microcrystalline cellulose, 2 parts of pregelatinized starch, 4 parts of cross-linked polyvinylpyrrolidone (PVPP), and 0.4 part of micropowdered silica gel;

[0058] Preparation of Ganoderma lucidum extract: take the liquid fermentation product of Chizhi fungus, filter it, and concentrate the filtrate to a thick paste with a relative density of 1.05 at 65°C; the residues are extracted with 60% ethanol microwave, the microwave power is 450w, and the extraction temperature is 50°C. Twice, the amount of ethanol used is 6 times the weight of the residue, the extraction time is 20min, the secondary extracts are combined, the recovered ethanol is concentrated into a thick paste, combined with the thick paste of the above fermentation broth, stirred well, concentrated under reduced pressure to 65°C and the relative...

Embodiment 2

[0061] A preparation method of Ganoderma lucidum extract sheet:

[0062] Wherein, the weight ratio of each raw material is: 12 parts of Ganoderma lucidum extract, 5 parts of microcrystalline cellulose, 3 parts of pregelatinized starch, 6 parts of cross-linked polyvinylpyrrolidone (PVPP), and 1.1 parts of micropowdered silica gel;

[0063] Preparation of ganoderma lucidum extract: Take the liquid fermentation product of red lucidum fungus, filter, and concentrate the filtrate to a thick paste with a relative density of 1.10 at 65°C; the residue is extracted by microwave with 75% ethanol, the microwave power is 550W, and the amount of ethanol is 7 times the residue Weight, extraction temperature 70°C, extraction time 30min, extract twice, combine the secondary extracts, recover ethanol and concentrate into a thick paste, combine with the thick paste of the above fermentation broth, stir well, and concentrate under reduced pressure to 65°C with a relative density of 1.23 clear oi...

Embodiment 3

[0066] A preparation method of Ganoderma lucidum extract sheet:

[0067] Wherein, the weight ratio of each raw material is: 15 parts of Ganoderma lucidum extract, 5 parts of microcrystalline cellulose, 4 parts of pregelatinized starch, 7 parts of cross-linked polyvinylpyrrolidone (PVPP), 1.5 parts of micropowdered silica gel;

[0068] Preparation of Ganoderma lucidum extract: Take the liquid fermentation product of Chizhi fungus, filter it, and concentrate the filtrate to a thick paste with a relative density of 1.15 at 65°C; the residues are extracted by microwave with 90% ethanol respectively, the microwave power is 550w, the extraction temperature is 70°C, and the extraction Twice, the amount of ethanol is 8 times the weight of the residue, the extraction time is 40min, the secondary extracts are combined, the recovered ethanol is concentrated into a thick paste, combined with the thick paste of the above fermentation broth, stirred evenly, and concentrated under reduced pre...

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Abstract

The invention relates to a preparation method of a ganoderma lucidum extract tablet. The preparation method comprises the following steps: taking a ganoderma lucidum liquid fermented extract, filtering, and concentrating the filtrate to obtain a stiff paste; carrying out microwave-assisted extraction on residues with ethanol for two times, merging extracts obtained by the two times of microwave-assisted extraction, recovering ethanol and concentrating to obtain a stiff paste, merging the stiff paste with the above fermentation liquid paste, uniformly stirring, carrying out pressure reduction and concentrating to obtain a clear paste; and adding corresponding auxiliary materials to prepare the tablet. The ganoderma lucidum extract tablet prepared by the technology has advantages of good curative effect, stable preparation and little side effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a preparation method of ganoderma lucidum extract tablets. Background technique [0002] Ganoderma lucidum is a fungus of the genus Ganoderma lucidum of the basidiomycete polyporaceae family, and its fruiting body is commonly used, and it is a kind of medicinal fungus. Ganoderma lucidum is a treasure in the treasure house of traditional Chinese medicine, and it has a long history of being used as a medicine in my country. my country's earliest pharmacy book "Shen Nong's Materia Medica" listed Ganoderma lucidum as the top grade, effective and non-toxic, and believed that it could make people "lighten their lives and stay young". Ancient medical scientists have fully understood the medicinal value of Ganoderma lucidum, and believe that Ganoderma lucidum has the effect of "strengthening the body and strengthening the foundation", can replenish the qi of the five internal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/074A61K47/38A61K47/36A61K47/32A61K47/04A61K9/30A61K9/36A61P25/20A61P1/14A61P11/00A61P9/10
Inventor 付诚
Owner JIANGXI BAISHEN PHARMA
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