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Method for preparing vitamin ad pellets and compound amino acid capsule composition

A vitamin and amino acid technology, which is applied in the direction of microcapsules, active ingredients of hydroxyl compounds, drug combinations, etc., can solve the problems of poor stability of amino acid oral preparations, discoloration of product appearance, and decline in product content, etc.

Active Publication Date: 2020-03-10
SHENZHEN WANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the instability of amino acids, the stability of amino acid oral preparations is poor, which restricts the application of amino acid oral preparations
Chinese patent CN1781486, the name of the invention is: a compound amino acid and vitamin capsule preparation and its preparation method. It is believed that the product prepared by this invention is not stable. After 12 months, the appearance of the product changes color and the product content drops significantly.
In addition, CN101773512A discloses a micropill capsule of 8 kinds of amino acids and 11 kinds of vitamins and its preparation method, wherein the capsule shell includes 7 kinds of micropills, and it is believed that the 7 kinds of micropills in the micropill capsule will cause When the pellets are mixed and filled with capsules, the content of individual pellets is obviously uneven.

Method used

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  • Method for preparing vitamin ad pellets and compound amino acid capsule composition
  • Method for preparing vitamin ad pellets and compound amino acid capsule composition
  • Method for preparing vitamin ad pellets and compound amino acid capsule composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0173] The formula of 8 kinds of amino acids and 11 kinds of vitamin pellet capsules of the present invention is: wherein thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin pellets b, amino acid pellets b, vitamin C pellets and vitamin AD The weight ratio of these seven kinds of micropills round micropills is:

[0174] Thiamine nitrate pellets 6.88 Vitamin pellets a 17.1 Amino Acid Pellets a 36.8 Vitamin pellets b 12 Amino acid pellets b 7.56 Vitamin C Pellets 13.4 Vitamin AD pellets 6.2

[0175] 1. The formula of thiamine nitrate pellets is:

[0176] Thiamine nitrate 250g lactose 450g starch 45g Calcium Carboxymethyl Cellulose 75g Methylcellulose 22g Hydroxypropyl Cellulose 19g Titanium dioxide 23g microcrystalline cellulose 116g

[0177] 2. The formula of vitamin micropills a is:

[0178] Nicotinamide 360g thbrthdrexvbdr 100g ...

Embodiment 2

[0203] The formula of 8 kinds of amino acids of the present invention and 11 kinds of vitamin micropill capsules is:

[0204] Wherein the weight ratio of these seven kinds of micropills round micropills of thiamine nitrate micropills, vitamin micropills a, amino acid micropills a, vitamin micropills b, amino acid micropills b, vitamin C micropills and vitamin AD micropills is:

[0205] Thiamine nitrate pellets 2.66 Vitamin pellets a 16.35 Amino Acid Pellets a 35.0 Vitamin pellets b 11.4 Amino acid pellets b 6.65 Vitamin C Pellets 12.73 Vitamin AD pellets 5.7

[0206] 1. The formula of thiamine nitrate pellets is:

[0207] Thiamine nitrate 76g lactose 225g starch 9g Calcium Carboxymethyl Cellulose 15g Methylcellulose 4.4g Hydroxypropyl Cellulose 3.8g Titanium dioxide 4.6g microcrystalline cellulose 58g

[0208] 2. The formula of vitamin micropills a is:

[0209] ...

Embodiment 3

[0234] The formula of 8 kinds of amino acids and 11 kinds of vitamin micropellets capsules is:

[0235] Thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin pellets b, amino acid pellets b, vitamin C pellets and vitamin AD pellets, the weight ratio of these seven pellets is:

[0236] Thiamine nitrate pellets 9.9 Vitamin pellets a 20.5 Amino Acid Pellets a 44.1 Vitamin pellets b 14.4 Amino acid pellets b 10.5 Vitamin C Pellets 16.0 Vitamin AD pellets 9.36

[0237] 1. The formula of thiamine nitrate pellets is:

[0238]

[0239]

[0240] 2. The formula of vitamin micropills a is:

[0241] Nicotinamide 580g thbrthdrexvbdr 145g Vitamin B6 72g lactose 174.6g Calcium Carboxymethyl Cellulose 168g Hydroxypropyl Cellulose 32.4g microcrystalline cellulose 280.5g starch 149.4g

[0242] 3. The formula of amino acid pellet a is:

[0243] L-isoleu...

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Abstract

The invention relates to a method for preparing a vitamin AD pellet, and a compound amino acid capsule composition thereof. Concretely, on one hand, the invention relates to the vitamin AD pellet, which comprises vitamin A and vitamin D2; every 1g of pellet contains 2 to 200,000 I.U. of vitamin A and 0.2 to 20,000 I.U. of vitamin D2. The invention also relates to the preparation method of the vitamin AD pellet, which comprises a capsule of a compound amino acid vitamin pellet containing the vitamin AD pellet. The vitamin AD pellet and the compound amino acid vitamin capsule prepared by using the vitamin AD pellet have the characteristics of superior to existing products.

Description

technical field [0001] The present invention relates to a vitamin AD pellet, which has a small and concentrated particle size and is especially suitable for filling or filling components of hard capsules. The invention also relates to the preparation method of the vitamin AD pellets. In addition, the present invention also relates to a micropill capsule and a preparation method thereof, specifically, a capsule containing 8 kinds of amino acids and 11 kinds of vitamin micropills, which can also be called compound amino acid capsule (8-11). It relates to a preparation method of the capsule. Background technique [0002] Protein is the material basis of human life activities. Various physiological functions of the human body, especially immune function, cell damage repair function and growth and development function, are closely related to the normality of its metabolism. Under normal circumstances, the human body obtains various amino acids through the protein in food to ens...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K9/50A61K31/592A61K31/714A61P3/02A61P1/16A61K31/07A61K31/232A61K31/525A61K31/519A61K31/455A61K31/4415A61K31/405A61K31/375A61K31/355A61K31/198A61K31/197
CPCA61K9/1658A61K9/5084A61K31/07A61K31/197A61K31/198A61K31/232A61K31/355A61K31/375A61K31/405A61K31/4415A61K31/455A61K31/519A61K31/525A61K31/592A61K31/714A61K2300/00
Inventor 彭潇波马俊陈广进
Owner SHENZHEN WANHE PHARMA
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