Preparation method of olmesartan medoxomil tablets

A technology of olmesartan medoxomil tablet and olmesartan medoxomil tablet, which is applied in the field of medicine, can solve problems such as easy crystallization or precipitation, affecting drug absorption and utilization, and active ingredients are not easy to wet, so as to increase bioavailability and ensure absorption and bioavailability, the effect of facilitating industrial production

Inactive Publication Date: 2018-03-09
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Olmesartan medoxomil is a fat-soluble compound and is insoluble in water. When it is administered orally, because of the insolubility of the drug in water, the active ingredient of the common preparation composition containing olmesartan medoxomil is not easy to wet and not diffuse in water. Oral dosage forms prepared by preparation auxiliary materials and dispersion systems are prone to crystallization or precipitation in gastrointestinal fluids and cannot be dissolved, which greatly affects the absorption and utilization of drugs.

Method used

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  • Preparation method of olmesartan medoxomil tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This example provides the prescription and preparation method for preparing 1000 olmesartan medoxomil tablets (20 mg / tablet).

[0034] prescription:

[0035] Name of raw material Amount (g)

[0036] Olmesartan medoxomil 20

[0037] Lactose 40

[0038] Lactose 400

[0039] Microcrystalline Cellulose 410

[0040] Croscarmellose Sodium 40

[0041] Sodium Lauryl Sulfate 10

[0042] Magnesium Stearate 12.5

[0043] Makes 1000 pieces

[0044] Preparation method: (1) Weigh olmesartan medoxomil (20g) of the prescription amount and lactose (40g) twice the amount and mix evenly;

[0045] (2) Add the olmesartan medoxomil lactose mixture into the pulverizer and pulverize it for 3 minutes;

[0046] (3) Olmesartan medoxomil lactose mixed powder is mixed evenly with the lactose (400g) of prescription quantity;

[0047] (4) microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate that step (3) is obtained mixture and recipe quantity are mixed;

[0048] (5) st...

Embodiment 2

[0051] This example provides the prescription and preparation method for preparing 1000 olmesartan medoxomil tablets (20 mg / tablet).

[0052] prescription:

[0053] Name of raw material Amount (g)

[0054] Olmesartan medoxomil 20

[0055] Lactose 60

[0056] Lactose 600

[0057] Microcrystalline Cellulose 613

[0058] Croscarmellose Sodium 62

[0059] Sodium Lauryl Sulfate 16

[0060] Magnesium stearate 19

[0061] Makes 1000 pieces

[0062] Preparation method: (1) Weigh the olmesartan medoxomil (20g) of the prescription amount and the lactose (60g) of 3 times the amount and mix evenly;

[0063] (2) Add the olmesartan medoxomil lactose mixture into the pulverizer and pulverize it for 3 minutes;

[0064] (3) mix the olmesartan medoxomil lactose mixed powder with the lactose (600g) of prescription quantity;

[0065] (4) microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate that step (3) is obtained mixture and recipe quantity are mixed;

[0066] (5)...

Embodiment 3

[0069] This example provides the prescription and preparation method for preparing 1000 olmesartan medoxomil tablets (20 mg / tablet).

[0070] prescription:

[0071] Name of raw material Amount (g)

[0072] Olmesartan medoxomil 20

[0073] Lactose 100

[0074] Lactose 700

[0075] Microcrystalline Cellulose 750

[0076] Croscarmellose Sodium 100

[0077] Sodium Lauryl Sulfate 25

[0078] Magnesium Stearate 25

[0079] Makes 1000 pieces

[0080] Preparation method: (1) Weigh the prescription amount of olmesartan medoxomil (20g) and 5 times the amount of lactose (100g) and mix evenly.

[0081] (2) Add the olmesartan medoxomil lactose mixture into the pulverizer and pulverize for 5 minutes.

[0082] (3) Mix olmesartan medoxomil lactose mixed powder with the prescribed amount of lactose (700) evenly.

[0083] (4) Mix the mixture obtained in step (3) with the microcrystalline cellulose, croscarmellose sodium, and sodium lauryl sulfate in the prescribed amount.

[0084] (5) ...

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PUM

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Abstract

The invention discloses a method for preparing olmesartan medoxomil tablets, comprising: (1) mixing olmesartan medoxomil with water-soluble materials, and then pulverizing them; (2) pulverizing the olmesartan medoxomil tablets obtained in step (1) The mixture is mixed with one or more auxiliary agents, and then directly compressed to obtain olmesartan medoxomil tablets. The invention has the advantages of simple operation, short process steps, strong controllability, good reproducibility, convenient industrial production and cost saving.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of olmesartan medoxomil tablets. Background technique [0002] Olmesartan medoxomil (Olmesartan medoxomil), the chemical name is 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-(tetrazol-5-yl)benzene Base] phenyl] methylimidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl ester, is a new angiotensin II receptor inhibitors, which are hydrolyzed in vivo to form active acid structures, can relax vascular smooth muscle by preventing angiotensin II from binding to AT1 receptors, thereby lowering blood pressure. [0003] Olmesartan medoxomil is a fat-soluble compound and is insoluble in water. When it is administered orally, because of the insolubility of the drug in water, the active ingredient of the common preparation composition containing olmesartan medoxomil is not easy to wet and not diffuse in water. Oral dosage forms prepared by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4178A61K47/26A61P9/12
CPCA61K9/2095A61K9/2018A61K31/4178
Inventor 严洁王志凤
Owner TIANJIN HANKANG PHARMA BIOTECH
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