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Preparation method of high-uniformity vitamin AD pellets and vitamin AD pellets

A technology for vitamins and pellets is applied in the preparation of compound amino acid capsules and vitamin AD pellets. In the field of preparation of the capsules, it can solve the problems of decreased product content, discoloration of product appearance, poor product stability of amino acid oral preparations, etc.

Active Publication Date: 2019-03-08
SHENZHEN WANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the instability of amino acids, the stability of amino acid oral preparations is poor, which restricts the application of amino acid oral preparations
Chinese patent CN1781486, the name of the invention is: a compound amino acid and vitamin capsule preparation and its preparation method. It is believed that the product prepared by this invention is not stable. After 12 months, the appearance of the product changes color and the product content drops significantly.
[0009] However, the inventors have found in in-depth research that the use of such existing vitamin AD microbeads or vitamin AD micropills prepared by existing methods needs to be improved in terms of drug content uniformity

Method used

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  • Preparation method of high-uniformity vitamin AD pellets and vitamin AD pellets
  • Preparation method of high-uniformity vitamin AD pellets and vitamin AD pellets
  • Preparation method of high-uniformity vitamin AD pellets and vitamin AD pellets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1: 8 kinds of amino acids and 11 kinds of vitamins micropellet capsules

[0094]According to CN106902100A specification example 1 formula and preparation method, prepare six kinds of pellets of thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin b, amino acid pellets b, vitamin C pellets, and refer to CN106902100A Proportions of the corresponding examples 7 kinds of pellets were mixed to prepare capsules.

[0095] The formula ratio (per 1000mg) of vitamin AD pellets is:

[0096] Vitamin A Palmitate

58.8mg (100,000 iu vitamin A)

Corn oil

141.2mg

Calciferol

0.25mg (10,000 iu vitamin D2)

Span20

10mg

gelatin

572mg

sodium benzoate

0.87mg

Sodium dehydroacetate

1.45mg

sucrose

Add appropriate amount to make the total weight of the pellets 1000mg

[0097] Prepare vitamin AD pellets (basically with reference to the method of the corresponding embodiment ...

Embodiment 2

[0103] Example 2: 8 kinds of amino acids and 11 kinds of vitamins micropellet capsules

[0104] According to CN106902100A specification example 2 formula and preparation method, prepare six kinds of pellets of thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin b, amino acid pellets b, vitamin C pellets, and refer to CN106902100A Proportions of the corresponding examples 7 kinds of pellets were mixed to prepare capsules.

[0105] The formula ratio (per 1000mg) of vitamin AD pellets is:

[0106] Vitamin A Acetate

Equivalent to 150,000 VA

Soybean oil

120mg

Calciferol

15,000 VD 2

Span40

2mg

gelatin

400mg

Sapphire methyl ester

0.75mg

Sapphire ethyl ester

0.5mg

sucrose

Add appropriate amount to make the total weight of the pellets 1000mg

[0107] Prepare vitamin AD pellets (basically with reference to the method of the corresponding embodiment of CN106902100A, ...

Embodiment 3

[0113] Example 3: 8 kinds of amino acids and 11 kinds of vitamins micropellet capsules

[0114] According to CN106902100A specification example 3 formula and preparation method, prepare six kinds of pellets of thiamine nitrate pellets, vitamin pellets a, amino acid pellets a, vitamin b, amino acid pellets b, vitamin C pellets, and refer to CN106902100A Proportions of the corresponding examples 7 kinds of pellets were mixed to prepare capsules.

[0115] The formula ratio (per 1000mg) of vitamin AD pellets is:

[0116]

[0117]

[0118] Prepare vitamin AD pellets (basically with reference to the method of the corresponding embodiment of CN106902100A, only step (2) and step (3) are adjusted):

[0119] (1) Mix vitamin A, vitamin D2, edible vegetable oil, and sorbitan fatty acid ester (100°C) to dissolve to obtain an oily liquid; in addition, dissolve gelatin and sucrose (40°C) in water (water to gelatin weight ratio 6:1), then add preservative, stir to dissolve, and get ...

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Abstract

The invention relates to a preparation method of high-uniformity vitamin AD pellets and the vitamin AD pellets. Specifically, the vitamin AD pellets involved in one aspect of the invention comprise vitamin A and vitamin D2, and each gram of the pellets comprises 2-200000 I. U. Vitamin A and 0.2-20000 I. U. Vitamin D2.The preparation method of the vitamin AD pellets comprises the following steps of: dissolving an oily material to obtain oily liquid, dissolving an aqueous material to obtain aqueous liquid, emulsifying the mixture in a vacuum emulsifier to obtain emulsion, dropping the emulsion into curing oil through a dropping machine, carrying out cooling and solidification to form pellets, and filtering and drying the pellets to obtain the vitamin AD pellets. The vitamin AD pellets have excellent uniformity in the aspects of three-dimensional size as well as weight and active ingredient content.

Description

technical field [0001] The present invention relates to a vitamin AD pellet, which has a small and concentrated particle size and is especially suitable for filling or filling components of hard capsules. The invention also relates to the preparation method of the vitamin AD pellets. In addition, the present invention also relates to a micropill capsule and a preparation method thereof, specifically, a capsule containing 8 kinds of amino acids and 11 kinds of vitamin micropills, which can also be called compound amino acid capsule (8-11). It relates to a preparation method of the capsule. Background technique [0002] Protein is the material basis of human life activities. Various physiological functions of the human body, especially immune function, cell damage repair function and growth and development function, are closely related to the normality of its metabolism. Under normal circumstances, the human body obtains various amino acids through the protein in food to ens...

Claims

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Application Information

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IPC IPC(8): A61K31/07A61K31/592A61K31/355A61K31/714A61K31/375A61K31/197A61K31/519A61K31/4415A61K31/525A61K31/455A61K31/51A61K31/198A61K31/405A61K9/16A61K9/48A61K47/26A61P3/02A61P1/16A61P13/12A61P39/00A23L33/175A23L33/155A23L33/15
CPCA23L33/15A23L33/155A23L33/175A23V2002/00A61K9/1623A61K31/07A61K31/197A61K31/198A61K31/355A61K31/375A61K31/405A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/592A61K31/714A61P1/16A61P3/02A61P13/12A61P39/00A61K2300/00A23V2250/702A23V2250/71A23V2250/7104
Inventor 黄维佳陈志涛彭潇波
Owner SHENZHEN WANHE PHARMA
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