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Medicament for supplying DE calcium and preparation method thereof

The technology of a drug, calcium acetate, is applied in the field of drug supplementing DE calcium and its preparation, which can solve the problems of retention in the body, large toxic and side effects, and inability to be absorbed by the body, and achieve high bioavailability, low toxic and side effects, and safe medication Effect

Inactive Publication Date: 2010-06-30
广西强寿药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many kinds of calcium-supplementing drugs with different effects, including biologically active preparations and inorganic calcium salts. Some inorganic salts cannot be metabolized in the body, stay in the body, and cause some diseases. These are not in line with the characteristics of calcium supplementation drugs, and the drug effect cannot be fully exerted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The main steps of the preparation method of the present invention supplementing DE calcium medicine children's formula are:

[0027] (1) Weigh 10g of solid vitamin D according to D3, add appropriate amount of ethanol to dissolve, add 5g of PEG6000, 15g of dextrin and 3g of alcohol solution of acrylic resin II in sequence, mix well, evaporate the solvent, and dry at 45°C. Crush the dry matter, sieve it, wet it with water and pass it through a 16-mesh sieve to granulate it, dry it at 45°C, pass it through a 20-mesh sieve for granulation, and then prepare the sustained-release granules for future use;

[0028] (2) Weigh 50g of solid vitamin E according to 100% of vitamin E and add it to 400g of beta cyclodextrin with a stirrer, 60% ethanol as solvent, three-phase formula molar ratio is 1:8:12, inclusion time is 20min, Filter, dry the clathrate at low temperature, and set aside;

[0029] (3) 1760g of water-soluble calcium acetate that has been pulverized is dissolved in an...

Embodiment 2

[0032] The main steps of the preparation method of the formula for pregnant women who supplement DE calcium medicine of the present invention are:

[0033] (1) Weigh 8g of solid vitamin D according to D3, add appropriate amount of ethanol to dissolve, add 4g of PEG6000, 16g of dextrin and 2.8g of alcohol solution of acrylic resin II in sequence, mix well, evaporate the solvent, and dry at 45°C. Crush the dry matter, sieve it, wet it with water and pass it through a 16-mesh sieve to granulate it, dry it at 45°C, pass it through a 20-mesh sieve for granulation, and then prepare the sustained-release granules for future use;

[0034] (2) Weigh 50g of solid vitamin E according to 100% of vitamin E and add it to 300g of beta cyclodextrin with a stirrer, 60% ethanol as solvent, three-phase formula molar ratio is 1:6:10, inclusion time is 20min, Filter, dry the clathrate at low temperature, and set aside;

[0035] (3) Dissolve 1100 g of water-soluble calcium acetate that has been pu...

Embodiment 3

[0038] The main steps of the preparation method of the present invention's formula for supplementing DE calcium medicine for adults are:

[0039](1) Weigh 12g of solid vitamin D according to D3, add appropriate amount of ethanol to dissolve, add 6g of PEG6000, 18g of dextrin and 3.6g of alcohol solution of acrylic resin II in sequence, mix well, evaporate the solvent, and dry at 45°C. Crush the dry matter, sieve it, wet it with water and pass it through a 16-mesh sieve to granulate it, dry it at 45°C, pass it through a 20-mesh sieve for granulation, and then prepare the sustained-release granules for future use;

[0040] (2) Weigh 25g of solid vitamin E according to 100% of vitamin E and add it to 150g of β-cyclodextrin with a stirrer, 60% ethanol as solvent, the molar ratio of the three-phase formula is 1:6:10, and the inclusion time is 20min , filtered, the clathrate was dried at low temperature, and set aside;

[0041] (3) Dissolve 2200 g of water-soluble calcium acetate t...

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Abstract

The invention provides a medicament for supplying DE calcium and a preparation method thereof. The active ingredient of the medicament comprises the slow release grains made up of vitamin D and the double-layer tablet formed by pressing the quick release grains made up of vitamin E and calcium acetate. The preparation method comprises the following steps of: respectively preparing the slow release grains and the quick release grains, mixing with proper superfine silica powder, stirring, and then filling in two hoppers of a double-layer tablet press so as to press the tablet. The medicament prepared by using the method ensures that the vitamin D is not destroyed under the acid condition and the direct contact between the vitamin E and oxygen is prevented. After patient takes the medicine, the active ingredients of vitamin E and calcium acetate can be quickly disintegrated and absorbed in stomach and the vitamin D can be disintegrated and absorbed in intestines. The medicament is characterized by pesticide effect, high bioavailability and small side effect and is specially fit for children, pregnant woman, adult and old people to take for a long time.

Description

Technical field: [0001] The invention relates to a medicine and a preparation method thereof, in particular to a medicine for supplementing DE calcium and a preparation method thereof. Background technique: [0002] Double-layer tablets belong to the preparation form of oral solid preparations, and are managed as drugs and health food in the relevant laws and regulations on food and drug administration in my country. [0003] At present, there are two problems in the calcium intake of Chinese nationals. First, on the whole, the national calcium intake is indeed low. The recommended daily calcium intake published by the Chinese Nutrition Society is 800 mg, and the recommended calcium intake for teenagers and pregnant women is 1200-1500 mg, but the current national daily calcium intake is about 400 mg. Second, the national calcium intake varies greatly from region to region, and not everyone is deficient in calcium. People in pastoral areas and people in areas with a high i...

Claims

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Application Information

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IPC IPC(8): A61K31/59A61K31/355A61K31/19A61K9/24A61P3/02A61P3/14
Inventor 李浪辉
Owner 广西强寿药业集团有限公司
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