Compound ammonium glycyrrhizinato S dispersed tablet and its preparing process

A technology of compound licorice and glycyrrhizic acid monoammonium salt, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of injection production process requirements, inconvenient use, and poor stability, and achieve Guaranteed bioavailability, easy portability, and reliable quality control effects

Inactive Publication Date: 2007-02-28
黄本东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the compound glycyrrhizin preparations developed and marketed at home and abroad are only ordinary tablets and injections. Due to the high production process requirements and cost of injections, poor stability, and inconvenient use, tablets are often used as auxiliary therapeutic drugs for injections.

Method used

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  • Compound ammonium glycyrrhizinato S dispersed tablet and its preparing process
  • Compound ammonium glycyrrhizinato S dispersed tablet and its preparing process
  • Compound ammonium glycyrrhizinato S dispersed tablet and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1), the original and auxiliary materials are crushed through a 100-mesh sieve;

[0021] 2) Weigh and take 25g of monoammonium glycyrrhizinate S (calculated as glycyrrhizic acid), 25g of glycine, 25g of DL-methionine, 80g of microcrystalline cellulose, 40g of hydroxypropyl cellulose (low substitution), 40g of lactose, and micronized silica gel 15g, crospovidone 9g, sodium carboxymethyl starch 35g, mix homogeneously by the method of increasing in equal amounts, add 2% PVP ethanol (40%) solution, make soft material, soft material crosses 20 mesh sieves and granulates;

[0022] 3) Dry the wet granules at 60°C to 70°C for 3 to 4 hours, then sieve the granules with a 20-mesh sieve, add 0.62g of talc powder and 7g of crospovidone, mix evenly, and measure the content of the semi-finished product;

[0023] 4) After the content of the semi-finished product is qualified, use a circular chamfering die with a diameter of 11mm to press the tablet. The sheet shape is round, and the sh...

Embodiment 2

[0026] 1), the original and auxiliary materials are crushed through a 100-mesh sieve;

[0027] 2) Weigh 5g of monoammonium glycyrrhizinate S (calculated as glycyrrhizic acid), 30g of glycine, 5g of DL-methionine, 80g of microcrystalline cellulose, 40g of hydroxypropyl cellulose (low substitution), 40g of lactose, and micronized silica gel 15g, crospovidone 9g, sodium carboxymethyl starch 35g, mix homogeneously by the method of increasing in equal amounts, add 2% PVP ethanol (40%) solution, make soft material, soft material crosses 20 mesh sieves and granulates;

[0028] 3) Dry the wet granules at 60°C to 70°C for 3 to 4 hours, then sieve the granules with a 20-mesh sieve, add 0.62g of talc powder and 7g of crospovidone, mix evenly, and measure the content of the semi-finished product;

[0029] 4) After the content of the semi-finished product is qualified, use a circular chamfering die with a diameter of 11mm to press the tablet. The sheet shape is round, and the sheet weight ...

Embodiment 3

[0032] 1), the original and auxiliary materials are crushed through a 100-mesh sieve;

[0033] 2) Weigh and take 30g of monoammonium glycyrrhizinate S (calculated as glycyrrhizic acid), 5g of glycine, 30g of DL-methionine, 80g of microcrystalline cellulose, 40g of hydroxypropyl cellulose (low substitution), 40g of lactose, and micronized silica gel 15g, crospovidone 9g, sodium carboxymethyl starch 35g, mix homogeneously by the method of increasing in equal amounts, add 2% PVP ethanol (40%) solution, make soft material, soft material crosses 20 mesh sieves and granulates;

[0034] 3) Dry the wet granules at 60°C to 70°C for 3 to 4 hours, then sieve the granules with a 20-mesh sieve, add 0.62g of talc powder and 7g of crospovidone, mix evenly, and measure the content of the semi-finished product;

[0035] 4) After the content of the semi-finished product is qualified, use a circular chamfering die with a diameter of 11mm to press the tablet. The sheet shape is round, and the she...

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Abstract

The invention discloses a compound ammonium glycyrrhizinate S dispersible tablet, wherein the dispersible tablet is prepared from the following raw materials (by weight portion): monoammonium glycyrrhizinate S (calculated by glycyrrhizinic acid) 5-30 parts, glycine 5-30 parts, DL-methionine 5-30 parts, bulking agent 55-220 parts, crumbling agent 32-160 parts, lubricating agent 0.2-5 parts. The dispersible tablet has the advantages of shorter disintegration time, better dispersion state, faster medicament dissolving, quicker absorption, and higher biological availability, thus is especially suitable for the elder people and patients suffering from swallowing difficulty.

Description

technical field [0001] The invention relates to a monoammonium salt preparation and a preparation method thereof, in particular to a compound ammonium glycyrrhizinate S dispersible tablet composed of monoammonium glycyrrhizinate S, glycine and DL-methionine and a preparation method thereof. Background technique [0002] Compound Glycyrrhizin Tablets was first developed and marketed by Japan Minor Fayuan Pharmaceutical Co., Ltd. in 1948. The product name is "Mineng", and the English name is StronmgerNeo-MinophamgenC (SNMC). The main active ingredients are glycyrrhizin (glycyrrhizic acid), glycine , Methionine. Because Meineng has anti-allergic and anti-inflammatory effects, it was mainly used in the field of dermatology to treat various allergic skin diseases in the early stage. After 1958, a large number of basic research and clinical research showed that SNMC was effective in treating chronic hepatitis, which made it widely promoted and applied in the field of liver diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/704A61K31/198A61P1/16A61P17/04
Inventor 黄本东
Owner 黄本东
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