82 results about "Swallowing difficulty" patented technology

A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweetners and specified amounts of bioactive agents preferably having perforations in the body of the dosage form enabling it to disperse/dissolve rapidly upon application by the subject. A flexible film dosage form to accommodate higher drug loads without compromising the fast dispersing/dissolving characteristics is presented. The perforated film system is enabled to be used in various applications such as oral, mucosal and external environments. The perforated film dosage form therefore, additionally allows the usage of polymers that would otherwise have not been used due to insolubility or limited solubility in water.

The invention relates to a drug preparation and a preparation method thereof, in particular to a compound Alpha-ketonic acid chewable tablet used for curing chronic renal failure, and a preparation method thereof. The compound Alpha-ketonic acid chewable tablet comprises the following components: Alpha-ketophenylalanine calcium, Alpha-hydroxymethionine calcium, Alpha-ketoleucine calcium, Alpha-ketoisoleucine calcium, Alpha-ketovaline calcium, tryptophan, histidine, tyrosine, threonine, lysine, acetate, a filling agent, a bonding agent, a taste-masking agent, a lubricant and a coating agent. The compound Alpha-ketonic acid chewable tablet not only widens the dosage form range of the compound Alpha-ketonic acid chewable tablets, but also has the advantages of having good dispersing state, short disintegration time, fast drug dissolution, rapid absorption, high biological availability and convenient taking, being capable of being swallowed, chewed and sucked and being especially suitable for old people, stroke patients, patients with special diseases and patients having swallowing difficulty.

The invention provides a vitamin orally disintegrating tablet and a preparation method thereof; the medical prescription components comprise the combination of multiplex vitamins or single vitamin, a loading agent, a disintegrant, a sacarina and a lubricant, etc. The invention aims at providing the vitamin orally disintegrating tablet with simple technique and convenient taking, and is characterized in that the technical requirements are achieved by using disintegration technology and sacarina technology to make synergic action. The vitamin orally disintegrating tablet provided by the invention are rapidly disintegrated in the oral cavity into fine particles, so as to be beneficial to the dissolving and absorption of the vitamin, thus achieving the goal of effectively supplementing the vitamin needed by the human body in time. The preparation of the invention can be taken conveniently and is especially suitable for the people such as old people, children and the patients with some diseases who have swallowing difficulty and need to supplement vitamin, or in the special environment such as having no drinkable water in a journey and out of home.

The invention provides gel for assisting swallow of an oral solid medicinal preparation. The gel comprises the following components in percentage by weight: 0.1-0.5 percent of an acid-containing gel material for promoting disintegration, 0.1-5.0 percent of a gel material with lubricating and coating performance, 0.1-15.0 percent of a flavoring agent, and a proper amount of water. An oral solid medicinal preparation can be coated with the gel, so that the unpleasant taste of the medicine can be isolated, the smooth taste can be improved, the compliance of a patient can be improved, and a person with swallow difficulty can be assisted to take the medicine; and furthermore, the gel can be quickly disintegrated and dissolved in the body, so that the drug effect of the oral solid medicinal preparation in the body cannot be influenced.

The invention relates to composite calcium carbonate/vitamin D3 granules for children prepared from the raw materials, such as calcium carbonate/vitamin D3 and an adjuvant. The preparation is granules, each bag contains 1,250mg of calcium carbonate and vitamin D3 with an international unit of 200, and the adjuvant is selected from a diluent, a bonding agent, a wetting agent and a flavoring agent. The invention also relates to a preparation method of the composite calcium carbonate/vitamin D3 granules for children, a prescription and a preparation technology are feasible, so that the grannles are suitable for mass production; and the prepared composite calcium carbonate/vitamin D3 granules are good in granulation property, and have better degree of homogeneity and higher dissolution rate. The composite calcium carbonate/vitamin D3 granules for children disclosed by the invention are suitable for children, old people and the persons who have swallowing difficulties, especially suitable for children.

The invention relates to ubenimex disket and its process, a composition disket comprising such as active ubenimex, disintegrating agent, filler, suspending agent bond, glidant, corrigent. Said ubennimex disket is convenient for medication, suitable for the old and small children and patient with swallowing difficulties.

The invention relates to loratadine lyophilized tablets, and a lyophilization prescription and a technology thereof. The loratadine lyophilized tablets provided by the invention are prepared from a main medicine loratadine and medicinal auxiliary materials. When the tablets are taken, no water is used, and the tablets disintegrate rapidly in mouths. Therefore, the tablets are suitable for patients with swallowing difficulties such as old people and children. Also, the tablets are suitable to be used in trips with water source shortages. The tablets are advantaged in convenient administration, fast absorption, small first-pass effect, and small irritation to gastrointestinal mucous membranes. The market prospect of the tablets is wide. With the lyophilized tablets provided by the invention, side effects of loratadine can be substantially reduced. Also, the invention relates to a preparation method of the loratadine lyophilized tablets.

The present invention relates to the technical field of medicine, health care, and food, particularly to a calcium oral cavity rapid-dissolving membrane agent and a preparation method thereof. According to the present invention, the calcium oral cavity rapid-dissolving membrane agent comprises a calcium source, vitamin D, a membrane material, a disintegrating agent, a filler, a plasticizer a flavoring agent, has characteristics of a certain flexibility and easy taking, does not produce discomfort during the taking, can be simply dissolved or disintegrated in the oral cavity, enters the digestive tract along with the swallowing action so as to be absorbed, has high solubility, and rapidly provide the effect, wherein the dissolving time of the calcium oral cavity rapid-dissolving membrane agent in 37 DEG C water is within 30 s; and the calcium oral cavity rapid-dissolving membrane agent further has pleasant taste and good palatability, can be taken without water, and is especially for children, elderly, and patients having swallowing difficulty.

The invention relates to aIlex kudingcha C. J. Tseng product and Ilex kudingcha C. J. Tseng nutritious effervescent tablet production process. the main component of the Ilex kudingcha C. J. Tseng nutritious effervescent tablet is Ilex kudingcha C. J. Tseng extract; the effervescent agent is made by mixing alkaline particles and acidic particles, and tabletting; the alkaline particles are made from Ilex kudingcha C. J. Tseng extract, sodium carbonate, lactose, glucose and sweetening agent; and the acidic particles are made from Ilex kudingcha C. J. Tseng extract, vitamin C, adipic acid, citric acid and glucose. The Ilex kudingcha C. J. Tseng nutritious effervescent tablet of the present invention can disintegrates into aqueous solution rapidly caused by the acid base reaction, it not only avoids the swallow difficulty of tablet, but also improves the mouth feel while being taken, and enable people to increase the nutrient composition absorption while enjoy drinks.

Dual-axis swallowing accelerometry is an emerging tool for the assessment of dysphagia (swallowing difficulties). These signals however can be very noisy as a result of physiological and motion artifacts. A novel scheme for denoising those signals is proposed, i.e. a computationally efficient search for the optimal denoising threshold within a reduced wavelet subspace. To determine a viable subspace, the algorithm relies on the minimum value of the estimated upper bound for the reconstruction error. A numerical analysis of the proposed scheme using synthetic test signals demonstrated that the proposed scheme is computationally more efficient than minimum noiseless description length (MNDL) based de-noising. It also yields smaller reconstruction errors (i.e., higher signal-to-noise (SNR) ratio) than MNDL, SURE and Donoho denoising methods. When applied to dual-axis swallowing accelerometry signals, the proposed scheme improves the SNR values for dry, wet and wet chin tuck swallows. These results are important to the further development of medical devices based on dual-axis swallowing accelerometry signals.

The invention discloses high-density dimethyl fumarate enteric-coated granules and a preparation method thereof. The density of the high-density dimethyl fumarate enteric-coated granules is 1.0g/mL or higher, or is 1.3g/mL or higher, or is 1.6g/mL or higher. Preparation size of the high-density dimethyl fumarate enteric-coated granules is small; the high-density dimethyl fumarate enteric-coated granules are convenient for administration, and are especially suitable for patients, elders, and children with swallowing difficulty, and are capable of increasing patient compliance; preparation content uniformity is high; rapid release is realized; stability is high; and the preparation method is simple, and is suitable for industrialized production.

The invention discloses a traditional Chinese medicine chewable tablet for treating upper respiratory tract infection and a preparation method of the chewable tablet. The traditional Chinese medicine chewable tablet is a solid preparation prepared from radix scutellariae extractive, jasmine extractive and medical additives according to proper proportions and proper procedures; and the traditional Chinese medicine chewable tablet can not only effectively resist against virus and sterilize, but also has such functions as clearing heat, anti-inflammatory and analgesia, etc. Compared with the common tablets, the traditional Chinese medicine chewable tablet disclosed by the invention has the advantages of good taste, quick absorption, fast effect taking, strong action, good compliance and the like, is convenient to take, and is especially suitable for elders, children and swallowing difficulty patients. The invention further discloses a quality detecting method of the traditional Chinese medicine chewable tablet. The quality detecting method comprises verifying, checking and content measuring procedures. The precision of the quality control method is high, the reproducibility is good, the recovery is high, the preparation quality can be effectively guaranteed, and the clinic treatment effect is fully guaranteed.

The invention discloses a clopidogrel soluble tablet and a preparation method thereof. The soluble tablet contains an active ingredient of clopidogrel or pharmaceutically acceptable salts and pharmaceutical excipients, wherein the pharmaceutical excipients comprise soluble excipients. The ratio of the clopidogrel to the soluble excipients is 1:1-10 in percentage by weight. The soluble tablet can also contain a disintegrant and a lubricant. The preparation method for the clopidogrel soluble tablet can be a direct tabletting method or a wet granulation tabletting method. Compared with a common tablet, the clopidogrel soluble tablet has the advantages of fast disintegration and formation of solution state in water within a short period of time, is easy in storage and use and particularly convenient for a patient with swallowing difficulty, and significantly improves the compliance of the patient.

The invention provides a celecoxib chewable tablet and a preparation method thereof. The celecoxib chewable tablet consists of the following raw materials in percentage by weight: 5-30% of celecoxib, 5-20% of disintegrating agent, 20-80% of filler, 5-30% of adhesive, 0.5-5% of flow aid and 0.5-3% of surfactant. The celecoxib chewable tablet has the advantages of both tablets and fluid preparations and has the characteristics of even dispersion, very short disintegrating time limit, fast medicament dissolution and high bioavailability, and is better convenience to take. The celecoxib chewable tablet is especially suitable for the aged and the patients who have swallowing difficulties. Upon inspection, the celecoxib chewable tablet shows that the quality indexes such as content, characteristics, identification, disintegrating time limit and dissolution accord with the 2010 edition of China Pharmacopoeia and relevant regulations. The bioavailability of the celecoxib chewable tablet is higher than the tablets on sale.

The invention relates to a ginseng fruit product and ginseng fruit nutritious effervescent tablet production process. the main component of the ginseng fruit nutritious effervescent tablet is ginseng fruit extract; the effervescent agent is made by mixing alkaline particles and acidic particles, and tabletting; the alkaline particles are made from ginseng fruit extract, sodium carbonate, lactose, glucose and sweetening agent; and the acidic particles are made from ginseng fruit extract, vitamin C, citric acid and glucose. The ginseng fruit nutritious effervescent tablet of the present invention can disintegrates into aqueous solution rapidly caused by the acid base reaction, it not only avoids the swallow difficulty of tablet, but also improves the mouth feel while being taken, and enable people to increase the nutrient composition absorption while enjoy drinks.

The invention discloses carteolol orally disintegrating tablets and a preparation method thereof. The orally disintegrating tablets comprise the following compositions in percentage by mass: 0.1 to 10 percent of carteolol, 50 to 90 percent of filler, 5 to 40 percent of disintegrating agent, 0.1 to 5 percent of lubricant and 0.1 to 5 percent of flavoring agent. The orally disintegrating tablets can be quickly disintegrated in oral cavity, has quick absorption, quick response, small first-pass effect of the liver, high biological utilization rate and small irritation on gastrointestinal tract, is convenient for taking, has excellent taste and is particularly suitable for old people, children and patients with swallow difficulty or drinking inconvenience. The orally disintegrating tablets are prepared by adopting a wet granulation and tableting method or a direct powder tableting method, have simple manufacture process, low cost, easily controlled quality, stable preparation, safety and efficiency, are applicable to large-scale industrial production and have wide market prospect.

The invention discloses 3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and a preparation method for the same. The dispersible tablets are prepared from the following components in percentage by weight: 10 to 30 percent of hawthorn leaf flavonoids, 55 to 80 percent of microcrystalline cellulose, 10 to 15 percent of povidone, 0.1 to 0.5 percent of aerosil and 0 to 0.5 percent of a flavoring agent. Compared with conventional compressed Yixintong dispersible tablets, the hawthorn leaf flavonoid dispersible tablets printed by a 3DP technology have the characteristics of higher disintegration speed, higher bioavailability, more convenience for administration and the like, are particularly suitable for patients with swallowing difficulties, and can work faster to meet treatment requirements of acute diseases such as angina pectoris and cerebral ischemia. Moreover, compared with the prior art, the 3DP technology has the advantages that dosages suitable for the patients can be customized to realize personalized medication and accurate treatment according to individual differences of the patients and degrees of symptoms, so that tablets taken by the patients are reduced, maximum curative effects of the tablets are achieved, and the toxic or side effects of the tablets are maximally reduced.

The invention discloses a spina date seed total saponin dispersible tablet and a preparation method thereof. The dispersible tablet is characterized by convenient administration, fast dispersion, easy absorption, high bioavailability, and stable quality. The dispersible tablet comprises: 5%-30% of a spina date seed saponin extract; 10%-20% of a disintegrating agent; 1%-10% of a lubricant; 1%-5% of a flavoring agent, and the balance a filler. The preparation method consists of: weighing the spina date seed saponin extract, the disintegrating agent, and the filler, conducting grinding and sieving, then mixing them evenly; adding the flavoring agent, and taking a 50%-75% ethanol solution as a wetting agent to prepare a soft material; performing granulating, drying wet granules, and straightening dried granules; adding the lubricant, mixing them evenly by an equal increment technique, and then performing tabletting. The spina date seed saponin extract dispersible tablet disclosed in the invention has the advantages of convenient administration, fast dispersion, easy absorption, high bioavailability, and stable quality, and is particularly suitable for the elderly and people with swallowing difficulty, thus providing a new way for utilization of spina date seed total saponins.

An orally disintegrating tablet of sedative-hypnotic medicine and a preparation method for the same are disclosed. The invention relates to an orally disintegrating tablet of sedative-hypnotic medicine as well as a prescription and a process for preparing the orally disintegrating tablet of sedative-hypnotic medicine by a freeze-drying method. The orally disintegrating tablet of sedative-hypnotic medicine disclosed by the invention is prepared from main medicines and pharmaceutical excipients, without the need of water while being taken, capable of being rapidly disintegrated in mouth, and suitable for the medication of the patients with difficulty in swallowing, such as the old and children; simultaneously, the orally disintegrating tablet of sedative-hypnotic medicine is suitable for the medication in a condition that water source is not easy to obtain during travelling; moreover, the orally disintegrating tablet of sedative-hypnotic medicine can avoid the influence on sleep due to micturition desire because of no need of water while being taken, thus exerting curative effect better; and the orally disintegrating tablet of sedative-hypnotic medicine disclosed by the invention has better compliance and therapeutic effect in the case that the patients with neurological disease are passive or incoordinate and for the old patients with insomnia compared with other forms, and can obviously reduce the side effects of the sedative-hypnotic medicine. Additionally, the invention further relates to a preparation method for an orally disintegrating tablet of sedative-hypnotic medicine.