The invention relates to the technical field of medicines, in particular to
ibuprofen water-free
swallowing granules and a preparation method thereof. The
ibuprofen water-free
swallowing particles are composed of
medicine carrying particles and taste modifying particles. The
medicine-carrying particles comprise the following components in percentage by weight: 50.0 to 95.0 percent of
ibuprofen, 0 to 20.0 percent of disintegrating agent, 0.5 to 25.0 percent of
adhesive and 0 to 50.0 percent of filling agent. The invention further discloses a preparation method of the
medicine-carrying particles. The
mass ratio of the ibuprofen to the disintegrating agent to the
adhesive is (80-90): (0-10): (5-20). And the
adhesive is selected from a low-melting-point adhesive. The medicine-carrying particles are granulated by a hot-melting granulator and then mixed with the taste-modifying particles. The ibuprofen water-free
swallowing granules prepared by the invention are convenient to carry, can be rapidly disintegrated in the
oral cavity and rapidly release medicines, enter gastrointestinal tracts along with swallowing actions to be absorbed, do not need to be swallowed by water, and are good in medication compliance and particularly suitable for patients with
swallowing difficulty to take.