Orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses an orally disintegrating tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The orally disintegrating tablet comprises 0.5-30 wt% of an active component, 25-35 wt% of an adhesive, 25-65 wt% of a filler and 1-10 wt% of a suspending aid, the active component comprises an antipsychotic raw material medicine and / or an antiepileptic raw material medicine. The void ratio of the orally disintegrating tablet is controlled to be 40-90%, even if the active ingredient is a low-solubility raw material medicine, the orally disintegrating tablet also has the fluffy feeling like puffed food, good taste and pleasant experience, meanwhile, the provided orally disintegrating tablet enables the medicine to be rapidly released in the oral cavity, the disintegration time in the oral cavity is shorter than 5 s, and the orally disintegrating tablet is suitable for oral administration. Compared with the oral cavity disintegration time of about 20s of disintegrating tablets and the oral cavity disintegration time of about 15s of oral soluble films in the prior art, the tablet has remarkable advantages, improves the compliance of patients, and greatly reduces the possibility of Tibetan medicine and vomiting of the patients especially for patients with dysphagia.

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