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Eye gellan gum in-situ gel made of bendazac lysine and preparing method of eye gellan gum in-situ gel

A technology of benzyl lysine eye and benzyl lysine, which is applied in the field of gellan gel for benzyl lysine ophthalmic use and its preparation, can solve eye irritation, reduce drug efficacy, and prevent the occurrence of preservatives Response and other problems, to achieve the effect of reducing irritation, convenient drug administration, and convenient operation

Active Publication Date: 2015-12-02
BEIJING GUGE MEDICINE DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problems of present Bendaxalysine instant gel preparations are: (1) eye irritation; (2) main ingredient is easy to react with preservatives, reducing drug efficacy

Method used

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  • Eye gellan gum in-situ gel made of bendazac lysine and preparing method of eye gellan gum in-situ gel
  • Eye gellan gum in-situ gel made of bendazac lysine and preparing method of eye gellan gum in-situ gel
  • Eye gellan gum in-situ gel made of bendazac lysine and preparing method of eye gellan gum in-situ gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]

[0043]

[0044] Preparation method: take gellan gum, hydroxypropyl methylcellulose and purified water to make a gellan gum solution with a weight percent content of 0.6%, shake well, sterilize at 105°C for 15 minutes, let cool to room temperature; take mannitol , Bendalysine, chlorobutanol, tromethamine, add purified water and stir to dissolve, add 66.7ml of the above-mentioned gellan gum solution with a weight percentage content of 0.6%, add purified water to 100ml, 0.22μm The product is obtained by filtering through a pore filter membrane and subpackaging, the content of benda lysine is 0.5% by weight, and the final weight percentage concentration of gellan gum is 0.4%. The pH value is 7.00 and the osmotic pressure is 300 mOsmol / kg.

[0045] In vitro release test: 1.0mL of commercially available Benda-lysine eye drops (5mg / ml) and gellan collagen site gel made in Example 1 were precisely pipetted respectively into a dialysis bag with a molecular cut-off of 350...

Embodiment 2

[0047]

[0048]

[0049] Preparation method: take gellan gum and purified water to make a gellan gum solution with a mass percentage concentration of 0.6%, shake well, sterilize at 105°C for 15 minutes, let cool to room temperature; take sorbic acid and tromethamine and add 20ml Heat the purified water to dissolve, add mannitol and benzyl lysine, stir to dissolve, add 66.7ml of gellan gum solution with a mass percentage concentration of 0.6%, add purified water to 100ml, filter through a 0.22um microporous membrane, and pack That is, the mass percentage content of benzyl lysine is 0.5%, and the final mass percentage concentration of gellan gum is 0.4%. The pH value is 7.23 and the osmotic pressure is 286mOsmol / kg.

[0050] Rabbit eye irritation test: Take 4 healthy New Zealand rabbits that have passed the quarantine inspection, half male and half male. The left and right sides of the same body were used as self-control, and the left eye of each rabbit was given the test...

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Abstract

The invention discloses eye gellan gum in-situ gel made of bendazac lysine. The eye gellan gum in-situ gel made of bendazac lysine is prepared from 0.4%-1% of bendazac lysine, 0.2%-0.6% of gellan gum, 2%-8% of osmotic pressure modifier, 0.05%-0.2% of pH modifier, 0.05%-0.4% of bacteriostatic agent, 0%-0.2% of thickening agent and the balance purified water, wherein the pH modifier is tromethamine. The eye gellan gum in-situ gel made of bendazac lysine is good in stasis capability on the cornea, convenient to apply and good in application prospect. The invention further discloses a preparing method of the eye gellan gum in-situ gel made of bendazac lysine. The method is easy and convenient to implement, easy to control and suitable for industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical ophthalmic drug delivery preparations in pharmacy, in particular to a gellan gel for ophthalmic benzal-lysine and a preparation method thereof. Background technique [0002] Among many ophthalmic diseases, cataract is one of the most common blinding eye diseases, manifested as opacity of the lens itself or lens capsule. According to World Health Organization statistics, blindness caused by cataract accounts for about 40%, the incidence of senile cataract at the age of 50-60 accounts for 60%-70%, and those over 70 years old is as high as 80%. Cataract has a high incidence rate and poor prognosis, which has seriously affected people's work and life. And with the arrival of population aging society, the incidence rate will increase. Although cataract can be treated surgically, surgical treatment is expensive, and in developing countries, surgery is far behind the newly increased patients. Therefore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/416A61K47/36A61P27/12
Inventor 申屠建中金晶王俏王华汤湛
Owner BEIJING GUGE MEDICINE DEV CO LTD
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