Nanoparticle and polymer composite particle and application thereof

A technology of composite particles and nanoparticles, applied in the field of biomedicine, can solve problems such as unretrieved, achieve high dispersibility and stability, improve oral bioavailability of drugs, and save costs

Active Publication Date: 2014-03-26
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although there are many studies on nanoparticles and polymer composite particles in the existing literature, due to the vast application space, composite nanoparticles with various structures and properties are still required to appear.
And about the composite nanoemulsion mentioned in this patent, no relevant reports have been retrieved so far

Method used

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  • Nanoparticle and polymer composite particle and application thereof
  • Nanoparticle and polymer composite particle and application thereof
  • Nanoparticle and polymer composite particle and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This embodiment relates to the preparation method of the composite particle of rice particle and polymer; The materials involved are as follows: hydrophilic SiO 2 Gift from Evonik Degussa Company; methyl methacrylate (MMA), methacrylic acid (MAA), n-butyl acrylate (BA), ammonia water, ammonium persulfate (APS) were purchased from Sinopharm Chemical Reagent Co., Ltd.; preparation methods include Follow the steps below:

[0043] Weigh 0.402g hydrophilic SiO 2 , add 20ml of ultrapure water, stir for 15 minutes, put it into an ultrasonic cleaner, and ultrasonicate for 30 minutes at 80% power;

[0044] Then at a stirring speed of 1500rpm, add 0.98mlMAA, 9.8mlH 2 O, 0.686ml NH 3 ·H 2 A mixture of O, and 0.98ml MMA and 0.98ml BA;

[0045] After slowly raising the temperature to 60-70°C, add 40mgAPS dissolved in 1ml of water, reduce the rotation speed, and continue to heat up to 80°C. Add 200ul NH after 10min 3 ·H 2 O, keep warm at 80° C. for 2 hours; leave at room temp...

Embodiment 2

[0058] This example involves the preparation of a composite nanoemulsion: take 2.7ml of the aqueous dispersion of composite nanoparticles prepared in Example 1, add 0.3ml of corn oil, mix well, and sonicate for 10 minutes with a cell disruptor. The test results are as follows:

[0059] 1. Zeta potential and particle size detection

[0060] The prepared composite nanoemulsion was diluted 200 times, ultrasonically degassed, and measured particle size and Zeta potential on a Zetasizer Nano-ZS90 particle size analyzer;

[0061] Table 2

[0062] samples

Nanoemulsion

Particle size

330nm

polydispersity index

0.223

Zeta potential

-45.8mV

[0063] 2. Transmission electron microscope (TEM) detection

[0064] Dilute the prepared composite nanoemulsion 100 times, then take 100ul diluted composite nanoparticles and 100ul phosphotungstic acid (NaPTA) to vortex for 30s, and then place it for 10min to make it fully mixed. Take 20ul ...

Embodiment 3

[0066] Preparation of cyclosporin A drug-loaded nanocomposite emulsion system: 10 mg of cyclosporin A was dissolved in 1 ml of soybean oil. Mix 2.7ml of the composite nanoparticle dispersion prepared in Example 1 with 0.3ml soybean oil dissolved in cyclosporin A, after mixing, the cells are broken and ultrasonicated for 10min to obtain a composite nanoemulsion system of cyclosporin A .

[0067] The matching drug-loaded composite nanoemulsion system was given to rats by intragastric administration, and then blood samples were collected at different time points, and the plasma concentration of cyclosporine was detected by LC-MS, and the oral biological activity of the drug was calculated. Utilization. The results show that the bioavailability of the composite nanoemulsion system is 3 times higher than that of the common composite emulsion prepared by polymer surfactant.

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Abstract

The invention relates to a nanoparticle and polymer composite particle and an application thereof in the field of biomedicines. The nanoparticle and polymer composite particle is prepared from an organic monomer and inorganic nanoparticles through in-situ polymerization. In addition, the invention relates to an application of the nanoparticle and polymer composite particle as a coating or stable dispersion, and also relates to a composite emulsion system comprising a waterborne continuous phase and an oil phase, and the nanoparticle and polymer composite particle is obtained through mixing an aqueous dispersion of the composite particle with the oil phase and dispersing, wherein the volume of the oil phase is 1 / 100-100 times that of the aqueous dispersion. The invention also relates to a medicine-carrying composite emulsion system. The nanoparticle and polymer composite particle provided by the invention is favorable in dispersibility and stability in a water solution and wide in application in the field of biomedicines.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to composite particles of nanoparticles and polymers and applications thereof. Background technique [0002] Nanoparticles and polymer composite particles have received extensive attention due to their good thermal properties, optical properties, electrical properties, and mechanical properties. hotspot. [0003] Chinese patent application publication CN1341682A mentions a modified methacrylate polymer / SiO2-TiO2 nanocomposite material and its preparation method and application. The preparation method adopts inorganic substances in the polymer phase through sol-gel, in-situ reaction, dispersion and compounding. The material can be used as a barrier material for packaging / encapsulation. [0004] Chinese patent application publication CN101885905A refers to the preparation and use of polymer / inorganic nanoparticle composite particles, involving primary composite particles form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/12C08L33/02C08L33/08C08K3/36C08K3/22C08F220/14C08F220/06C08F220/18C08J3/07C09D133/02C09D7/12A61K9/107A61K47/32A61K47/04
Inventor 徐宇虹马新瑞孙文强魏晓慧
Owner SHANGHAI JIAO TONG UNIV
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