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Pharmaceutical composition containing interferon and application

A technology of interferon and composition, applied in the field of pharmaceutical composition containing interferon, can solve the problem of not providing synergistic data, etc., achieve the effect of significantly improving practical value, reducing dependence and side effects, and meeting drug needs

Inactive Publication Date: 2013-10-09
澳蒲生物科技(上海)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent application CN03159223.6 discloses the compound composition and preparation of interferon α-2b and lentinan or interferon α-2a and mannan peptide, but does not provide corresponding synergistic data

Method used

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  • Pharmaceutical composition containing interferon and application
  • Pharmaceutical composition containing interferon and application
  • Pharmaceutical composition containing interferon and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] Preparation formula (nasal spray, 10.5 ml per tube, 10,000 tubes in total):

[0022]

[0023] Accurately weigh taurine, EDTA disodium (ethylenediaminetetraacetic acid disodium salt), dextran 4000, sodium chloride, potassium chloride and potassium dihydrogen phosphate in the above formula, add 80000mL of water for injection to dissolve completely Then add glycerin, Tween 80 and peppermint oil in the above-mentioned formula, and add water for injection to be constant to 105000mL, stir and mix uniformly; Get above-mentioned mixed solution 104329mL and 671mLα-2b type recombinant human interferon stoste mix again; Finally 10.5mL each is subpackaged to obtain 10,000 nasal sprays.

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing interferon and an application. Pharmacologically active ingredients of the pharmaceutical composition are the interferon and taurine, wherein an activity unit content of the interferon is 10 to 1x10<6> IU / mL, and a content of the taurine is 0.05-0.5 mg / ml. The pharmaceutical composition containing the interferon provided by the invention has effects of resisting activity of vesicular stomatitis virus and murine encephalomyocarditis virus, and protecting cells. Especially, each of nasal spray agent provided by the invention only has 50000 IU of alpha-2b recombinant human interferon and 1 mg of the taurine, but has a specific anti-viral activity of 9.15x10<5> to 2.8x10<6> IU, and shows substantial synergistic effect, thereby being significant for improving patient compliance and reducing medication costs, and meeting clinical needs of interferon medications.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing interferon and its application, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Interferon (IFN) is a broad-spectrum antiviral agent, which does not directly kill or inhibit the virus, but mainly through the action of cell surface receptors to make cells produce antiviral proteins, thereby inhibiting the replication of hepatitis B virus; at the same time, it can also enhance the natural The activity of killer cells (NK cells), macrophages and T lymphocytes plays an immune regulatory role and enhances antiviral ability. Interferon is a group of active proteins (mainly glycoproteins) with multiple functions and a cytokine produced by monocytes and lymphocytes. They have broad-spectrum anti-virus, affect cell growth and differentiation, regulate immune function and other biological activities on the same kind of cells. The methods of administr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61K9/12A61P31/12A61P31/16A61K31/185
Inventor 莫罗佐夫·德迷特例·瓦连吉诺维奇
Owner 澳蒲生物科技(上海)有限公司
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