Silky fowl soft capsule and preparation method thereof

A black-bone chicken, white phoenix, and soft capsule technology, which is applied in capsule delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of increased cross-linking degree of gelatin, accelerated aging of soft capsules, denaturation and hardening, etc.

Inactive Publication Date: 2015-07-01
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing traditional Chinese medicine soft capsule preparation technology still has the following problems: Oxygen and aldehydes can chemically react with gelatin, resulting in increased crosslinking, denaturation and hardening of gelatin, resulting in unqualified disintegration. Among them, aldehydes may exist in In the capsule fluid; delamination is prone to occur during storage. After delamination, the capsule fluid and the capsule material are in full contact, which can accelerate the aging of the soft capsule, which requires great attention

Method used

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  • Silky fowl soft capsule and preparation method thereof
  • Silky fowl soft capsule and preparation method thereof
  • Silky fowl soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] A kind of Wuji Baifeng soft capsule is obtained by the following preparation method:

[0110] (1) Preparation of liquid medicine

[0111] Take 140 parts by weight of Wuji Baifeng extract and pulverize it, pass through a 100-mesh sieve, slowly add the fine powder to 195 parts of corn oil in stages, and mix well; then add 8.4 parts of agar, 0.39 parts of beeswax, 4 parts of citric acid and 3.5 parts of Sodium metabisulfite, mixed evenly; use a colloid mill to grind and mix for 50 minutes to obtain the medicinal solution, that is, the content, store it in another container, and let it stand for later use;

[0112] (2) Preparation of glue

[0113] Take 155 parts of gelatin, 42.5 parts of xylitol, and 130 parts of water, put them in a sol tank, fully swell, keep warm at 65°C for 40 minutes; add 2.5 parts of citric acid, 2.5 parts of sodium sulfite, 1.5 parts of zinc oxide, and 0.9 parts of cocoa bean pigment and 0.2 parts of methyl p-hydroxyphenylpropionate, stirred for 45...

Embodiment 2

[0122] Prescription of Wuji Baifeng Soft Capsules

[0123] The content is made of the following raw materials and pharmaceutical excipients in weight percentage:

[0124]

[0125] The soft capsule skin is made from the following raw materials in percentage by weight:

[0126]

[0127]

[0128] The mass ratio of content and soft capsule skin is 1:1.5

[0129] Wherein the black-bone chicken white phoenix extract is obtained by the following preparation method:

[0130] (1) Take medicinal materials in parts by weight: 60 parts of black-bone chicken extract, 110 parts of deer horn gum, 60 parts of vinegar turtle carapace, 50 parts of calcined oyster, 60 parts of mulberry octopus, 110 parts of ginseng, 30 parts of astragalus, 130 parts of angelica, white peony 110 parts, Vinegar Cyperus 110 parts, Asparagus 60 parts, Licorice 30 parts, Rehmannia glutinosa 220 parts, Rehmannia glutinosa 220 parts, Chuanxiong 60 parts, Yin Bupleurum 30 parts, Salvia miltiorrhiza 110 parts,...

Embodiment 3

[0135] The prescription of Wuji Baifeng Soft Capsules is:

[0136] The content is made of the following raw materials and pharmaceutical excipients in weight percentage:

[0137]

[0138] The soft capsule skin is made from the following raw materials in percentage by weight:

[0139]

[0140]

[0141] The mass ratio of the content and the soft capsule skin is 1:1.2

[0142] Wherein the black-bone chicken white phoenix extract is obtained by the following preparation method:

[0143] (1) Take medicinal materials in parts by weight: 50 parts of black-bone chicken extract, 100 parts of deer horn gum, 50 parts of vinegar turtle carapace, 30 parts of calcined oyster, 50 parts of mulberry octopus, 100 parts of ginseng, 20 parts of astragalus, 120 parts of angelica, white peony 100 parts, Vinegar Cyperus 100 parts, Asparagus 50 parts, Licorice 20 parts, Rehmannia glutinosa 200 parts, Rehmannia glutinosa 200 parts, Chuanxiong 50 parts, Silver Bupleurum 20 parts, Salvia milt...

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Abstract

The invention relates to a silky fowl soft capsule and a preparation method thereof. The silky fowl soft capsule is prepared by: subjecting, by weight, 50-60 parts of a silky fowl extract, 100-110 parts of deerhorn glue, 50-60 parts of vinegar processed turtle shell, 30-50 parts of calcined oyster, 50-60 parts of Mantis Egg-case, 100-110 parts of ginseng, 20-30 parts of astragalus, 120-130 parts of Chinese angelica, 100-110 parts of Radix Paeoniae Alba, 100-110 parts of vinegar processed cyperus rotundus, 50-60 parts of radix asparagi, 20-30 parts of licorice, 200-220 parts of rehmannia glutinosa, 200-220 parts of Radix Rehmanniae Preparata, 50-60 parts of Ligusticum wallichii, 20-30 parts of Radix Stellariae, 100-110 parts of Salvia Miltiorrhiza, 100-110 parts of Chinese yam, 50-60 parts of fried Euryale ferox, and 30-50 parts of Cornu Cervi Degelatinatum to extraction and adding appropriate auxiliary materials.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine soft capsule and a preparation method thereof. Background technique [0002] Wuji Baifeng Pills originated from the "Puji Prescription" compiled by the Imperial Medical Bureau in the Ming Dynasty, and was improved into Wuji Baifeng Pills by the imperial physicians in the Qing Dynasty. In modern times, it is mostly named after Wuji Baifeng Pills. The prescription composition of Wuji Baifeng pills varies greatly, and there are multiple prescriptions, such as Wuji Baifeng pills in the 2010 edition of Chinese Pharmacopoeia, Tongren Wuji Baifeng pills, Twelve Wuji Baifeng pills, and Wujibai pills in the ministerial standards. Phoenix slices, Wuji Baifeng capsules, etc. Black-bone Chicken Baifeng Pills are composed of 20 traditional Chinese medicines such as black-bone chicken, ginseng, white peony root, salvia miltiorrhiza, angelic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8965A61K9/48A61P29/00A61P1/06A61P21/02A61K35/57A61K35/32A61K35/586A61K35/618A61K35/64
Inventor 王磊金兆祥王琳张宇
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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