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Medicine composition for preventing and treating respiratory system diseases, as well as preparation method and application thereof

A technology for respiratory diseases and compositions, which is applied in the fields of respiratory diseases, drug combinations, pharmaceutical formulations, etc., can solve the problems of not being suitable for large-scale production, skin burning or pain, low patient compliance, etc., and achieve convenient portability Effects of carrying or long-distance transportation, reducing irritation, and broad market prospects

Inactive Publication Date: 2016-05-18
XIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these traditional dosage forms need to be adjusted and used immediately, and it is difficult to accurately put the adjusted fresh ointment into the application paper, which is inconvenient to use, low in production efficiency, not suitable for large-scale production, and cannot well meet market demand.
In addition, fresh ointments are highly irritating and often cause discomfort symptoms such as skin burning or pain, resulting in low patient compliance and failing to meet the patient's medication needs.

Method used

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  • Medicine composition for preventing and treating respiratory system diseases, as well as preparation method and application thereof
  • Medicine composition for preventing and treating respiratory system diseases, as well as preparation method and application thereof
  • Medicine composition for preventing and treating respiratory system diseases, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Preparation of external transdermal dispersible tablet of the present invention

[0026] The prescription is as follows:

[0027] White Mustard Seed 30g, Corydalis Corydalis 30g, Kansui 10g, Asarum 10g, Cross-linked Polyvinylpyrrolidone (PVPP) 60g, Pepper Water 35g, Magnesium Stearate 5g

[0028] The preparation method is as follows:

[0029] a, get white mustard seed, Corydalis Corydalis, Gansui, Asarum and pulverize respectively, pass 80 mesh sieves; Obtain raw material drug;

[0030] b. Take cross-linked polyvinylpyrrolidone (PVPP), pass through a 120-mesh sieve, add to the raw material medicine and mix evenly, then add pepper water and mix evenly to make a soft material, and make the soft material into 30-mesh wet granules through a swinging granulator , dry the wet granules in a hot air circulation oven at 40°C for 2 hours, pass through a 20-mesh medicine sieve, and sieve the granules to obtain dry granules. Add magnesium stearate to the dry granule...

Embodiment 2

[0032] Embodiment 2 Preparation of external transdermal dispersible tablet of the present invention

[0033] The prescription is as follows:

[0034] White Mustard Seed 30g, Corydalis Corydalis 30g, Kansui 15g, Asarum 15g, Low-substituted Hydroxypropyl Cellulose (L-HPC) 60g, 85% Ethanol 30ml, Talcum Powder 5g

[0035] The preparation method is as follows:

[0036] a, get white mustard seed, Corydalis Corydalis, Gansui, Asarum and pulverize respectively, pass through 80 mesh sieves, obtain raw material drug;

[0037] b. Take low-substituted hydroxypropyl cellulose (L-HPC), pass through a 120-mesh sieve, add it to the raw material drug and mix it evenly, then add 85% ethanol and mix it evenly to make a soft material, and pass the soft material through a rocking granulation mechanism Form 30-mesh wet granules, dry the wet granules in a hot air circulation oven at 40°C for 2 hours, pass through a 20-mesh medicine sieve, and sieve to obtain dry granules. Add talcum powder to the...

Embodiment 3

[0039] Embodiment 3 Preparation of external transdermal dispersible tablet of the present invention

[0040] The prescription is as follows:

[0041] White Mustard Seed 30g, Corydalis 30g, Kansui 15g, Asarum 15g, Croscarmellose Sodium 60g, Vinegar 30g, Micronized Silica Gel 5g

[0042] The preparation method is as follows:

[0043] a, get white mustard seed, Corydalis Corydalis, Gansui, Asarum and pulverize respectively, pass through 80 mesh sieves, obtain raw material drug;

[0044] b. Take croscarmellose sodium (CCMC-Na), pass through a 120-mesh sieve, add to the raw material medicine and mix evenly, then add vinegar and mix evenly to make a soft material, and pass the soft material through a rocking granulation mechanism Form 30-mesh wet granules, dry the wet granules in a hot air circulation oven at 35°C for 3 hours, pass through a 20-mesh medicine sieve, and sieve to obtain dry granules. Add micropowder silica gel to the dry granules, put them in a mixer and mix them e...

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Abstract

The invention provides a medicine composition for preventing and treating respiratory system diseases. The medicine composition is an externally applied preparation prepared from the following raw materials and auxiliaries in parts by weight: 10-50 parts of semen brassicae, 10-50 parts of rhizoma corydalis, 5-40 parts of kansui roots, 5-40 parts of asarum, 50-300 parts of a disintegrating agent, 30-60 parts of adhesive and 2-15 parts of a lubricating agent. The invention further provides a preparation method and application of the medicine composition. The medicine composition is prepared from specific raw materials and auxiliaries in a specific dosage. Compared with a traditional acupoint application preparations, the medicine composition has the advantages of equivalent curative effect and convenience in use, can be used for remarkably reducing the drug irritation for skin and improving the acceptance of drug users, and can meet the medication requirement of patients. The medicine composition is simple in preparation process, low in cost and high in production efficiency, is available for volume production, and can meet the market requirement.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating respiratory diseases, a preparation method and application thereof, and belongs to the field of medicines. Background technique [0002] Acupoint application is an external treatment method in which Chinese medicine or Chinese medicine extract is mixed with an appropriate matrix and (or) a transdermal absorption accelerator, and then applied to the skin surface or corresponding acupoints to achieve a therapeutic effect. Acupoint application has the best curative effect in dog days. Acupoint application medicines are mostly derived from "Lengxiaofang". Specific medicines are absorbed in specific acupoints, which can exert the pharmacological effects of medicines, and jointly cultivate lung qi, clear phlegm and relieve cough. asthma. Its curative effect has been affirmed by the field of traditional Chinese medicine, and it can effectively prevent and treat respiratory dise...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P11/06A61P11/02A61P11/00A61P37/08
CPCA61K9/0014A61K9/2027A61K9/2054A61K9/2059A61K9/2068A61K36/268A61K36/31A61K36/47A61K36/66A61K2300/00
Inventor 何宇新周清梅陈澄康莉李幼静钟君马文驰余杰
Owner XIHUA UNIV
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