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Citicoline sodium tablet and preparation method thereof

A technology of citicoline sodium and coated tablets is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, which can solve the problems of unstable tablets and achieve controllable quality. , reduce the cost of medicines, and ensure the effect of effectiveness

Active Publication Date: 2013-07-10
JINAN LIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies in the prior art, the inventor has studied and solved the problem that the citicoline sodium tablet is unstable due to the absorption of citicoline sodium through a lot of exploration, and provides a new type of citicoline sodium tablet and its preparation method, the present invention has the advantages of good stability, long-term storage resistance, good safety and low cost

Method used

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  • Citicoline sodium tablet and preparation method thereof
  • Citicoline sodium tablet and preparation method thereof
  • Citicoline sodium tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, a kind of citicoline sodium tablet, the composition of every 1000 is as follows:

[0036]

[0037] Coating Solution Prescription:

[0038] Hydroxypropyl Methyl Cellulose: Cellulose Acetate Phthalate 1:2 160g

[0039] 55% ethanol 800ml

[0040] The preparation method of above-mentioned citicoline sodium tablet is as follows:

[0041] (1) Mix 20g of the main ingredient with 20g of lactose, add the rest of the main ingredient, mix evenly, and grind through an 80-mesh sieve;

[0042] (2) Add starch and sodium carboxymethyl starch respectively and mix well, pass through 80 mesh sieve twice,

[0043] (3) Add 10% starch slurry, mix well to make soft material,

[0044] (4) 20 mesh sieves are granulated, 60 DEG C are dried, and 16 mesh sieves are granulated;

[0045] (5) Add magnesium stearate and mix evenly, tabletting, inspection;

[0046] (6) The preparation of coating liquid, take stomach-dissolving type coating powder and add ethanol to disperse;

[...

Embodiment 2

[0049] Embodiment 2, a kind of citicoline sodium tablet, the composition of every 1000 is as follows:

[0050]

[0051] Coating Solution Prescription:

[0052] Hydroxypropyl methylcellulose: polyvinyl acetal diethylamine acetic acid 1:1 170 parts

[0053] 900 parts of 60% ethanol.

[0054] The preparation method of above-mentioned citicoline sodium tablet is as follows:

[0055] (1) Mix 25g of the main ingredient with 25g of lactose, add the rest of the main ingredient, mix evenly, and grind through an 80-mesh sieve;

[0056] (2) Add starch and sodium carboxymethyl starch respectively and mix well, pass through 80 mesh sieve twice,

[0057] (3) Add 10% starch slurry, mix well to make soft material,

[0058] (4) 20 mesh sieves are granulated, 60 DEG C are dried, and 16 mesh sieves are granulated;

[0059] (5) Add magnesium stearate and mix evenly, tabletting, inspection;

[0060] (6) The preparation of coating liquid, take stomach-dissolving type coating powder and add...

Embodiment 3

[0062] Embodiment 3, a kind of citicoline sodium tablet, the composition of every 1000 is as follows:

[0063]

[0064] Coating Solution Prescription:

[0065] Hydroxypropyl Methyl Cellulose:Ethyl Cellulose 2:1 180 parts

[0066] 60% ethanol 1000 parts.

[0067] The preparation method of above-mentioned citicoline sodium tablet is as follows:

[0068] (1) Mix 30g of the main ingredient with 30g of lactose, add the rest of the main ingredient, mix evenly, and grind through an 80-mesh sieve;

[0069] (2) Add starch and sodium carboxymethyl starch respectively and mix well, pass through 80 mesh sieve twice,

[0070] (3) Add 10% starch slurry, mix well to make soft material,

[0071] (4) 20 mesh sieves are granulated, 60 DEG C are dried, and 16 mesh sieves are granulated;

[0072] (5) Add magnesium stearate and mix evenly, tabletting, inspection;

[0073] (6) The preparation of coating liquid, take stomach-dissolving type coating powder and add ethanol to disperse;

[00...

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Abstract

The invention provides a citicoline sodium tablet and a preparation method thereof. The citicoline sodium tablet provided by the invention contains citicoline sodium, starch, lactose, sodium carboxymethyl starch, 10% starch slurry and magnesium stearate. The prescription of a coating solution includes stomach-soluble coating powder and ethanol. The preparation method comprises the steps of: (1) preparation of an uncoated tablet: uniformly mixing main drugs with the lactose, grinding the mixture to pass through a 80-mesh sieve, respectively adding the starch and the sodium carboxymethyl starch and carrying out uniform mixing, passing through the 80-mesh sieve twice, adding the 10% starch slurry, adequately and uniformly mixing to prepare soft materials, carrying out pelletizing by utilizing a 20-mesh sieve, drying at 60 DEG C, adding the magnesium stearate, and carrying out uniform mixing, tabletting and testing; and (2) coating. The citicoline sodium tablet has the advantages of good stability, low cost, high active ingredient content and the like.

Description

technical field [0001] The invention relates to a citicoline sodium tablet and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Citicoline sodium is used for the treatment of neurological sequelae caused by craniocerebral injury and cerebrovascular accident, and can be used for the treatment of Parkinson's syndrome, and also has a certain effect on senile dementia; other such as delaying aging, Improving memory, etc. is also effective. Citicoline sodium can promote brain substance metabolism and improve cerebral circulation by reducing cerebrovascular resistance and increasing cerebral blood flow. It can also enhance the function of the ascending reticular activation system of the brainstem, enhance the function of the vertebral system, and improve motor paralysis. It is mainly used for acute traumatic brain injury and disturbance of consciousness after brain surgery. For hemiplegia caused by cerebral apoplexy, it can gradually...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K47/26A61K47/38A61K31/7068A61P25/00A61P25/16A61P25/28
Inventor 滕学厚马德重刘新宁曹悦兴
Owner JINAN LIMIN PHARMA
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