Preparation of composite motidine dispersant pills

A technology of dispersible tablets and tidin, which is applied in the field of preparation of compound famotidine dispersible tablets, can solve the problems of single taking method and dissatisfaction of patients, and achieve the effects of rapid disintegration, diversified taking methods and quick onset of action

Inactive Publication Date: 2005-02-09
金日制药(中国)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are defects such as single taking method and its taste may make some patients dissatisfied.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0054] The best embodiment of the invention is:

[0055] 1) Preparation of binder solution: Dissolve 30 points of sodium lauryl sulfate and povidone K in an appropriate amount of water to obtain a binder solution; or dissolve sodium lauryl sulfate in appropriate amount of water, and granulate when sprayed into the particles;

[0056] 2) Mixing: put famotidine, calcium carbonate, magnesium hydroxide, microcrystalline cellulose and 5-95% of the prescription amount of crospovidone into the wet mixing granulator, and mix well;

[0057] 3) Making soft material: add the binder solution into the wet mixing granulator, and stir to make soft material;

[0058] 4) Granulation: Pass the soft material through a swinging granulator, extrude and sieve, granulate, and dry;

[0059] 5) Granulation, etc.: sieve the granules, put them in a trough-shaped mixer, add crospovidone, aspartame, and peppermint powder essence with a prescription amount of 95-5%, stir evenly, tablet, quality inspectio...

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PUM

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Abstract

A dispersing tablet of famotidine features that on the basis of its chewing tablet, the special additives are used for it, such as excellent disintegrant (cross-linked povidone, sodium laurylsulfate, or microcrystal cellulose) and high-performance adhesive (povidone K30) are used in it. Its advantages are high disintegrating speed, high curative effect and high safety.

Description

technical field [0001] The invention relates to the technical field of western medicine dispersible tablets, especially the preparation method of compound famotidine dispersible tablets. Background technique [0002] Dispersible tablets are a commonly used pharmaceutical dosage form. According to the relevant drug laws and regulations of our country, changing the dosage form is regarded as a new drug research. The original dosage form is compound famotidine chewable tablet, which was approved by the U.S. FDA in 2000 by Johnson & Johnson-Merck. In China, this variety is applying for clinical trial research. Its characteristic is that it can take effect quickly and maintain the curative effect for a long time. The tablet is easy to swallow after chewing, accelerates disintegration, and improves curative effect. However, there is a single way of taking it, and its taste may make some patients dissatisfied. Dispersible tablets can be swallowed like ordinary ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/433A61P1/04
Inventor 毛友昌毛晓敏
Owner 金日制药(中国)有限公司
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