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Preparation method of artificial bear gall powder preparation

A technology of bear bile powder and preparation, which is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central pain relievers, etc., to achieve the effect of easy processing and solving the bottleneck of production capacity

Inactive Publication Date: 2020-10-20
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even more serious is the long-term resistance of animal protection organizations at home and abroad to live bear bile harvesting, especially the recent "Guizhentang" incident that has once again aroused widespread concern from the international and domestic communities, which has greatly affected the production of domestic bear bile powder and the development of related industries. brought unprecedented resistance

Method used

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Examples

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Effect test

preparation example Construction

[0023] A preparation method of artificial bear bile powder preparation, comprising the following steps:

[0024] S1, preparation of raw materials: poultry gall powder, beta cyclodextrin, sucrose, dextrin, stevia, menthol, peppermint oil, magnesium stearate, talcum powder, ethanol, starch, licorice extract powder, stevioside , PVA-4000, PVA-6000, glycerin, polyvinylpyrrolidone, hydroxypropylmethylcellulose, hydroxyethylcellulose, polyethylene glycol, dibutyl phthalate, colorant, silicon dioxide;

[0025] S2, after dissolving poultry gall powder with a buffer solution, centrifuge at 11000g, and filter several times to obtain filter residue and filtrate, and freeze-dry the filter residue for preservation;

[0026] S3, adding the above filtrate into a reactor equipped with 7α-hydroxysteroid dehydrogenase, 7β-hydroxysteroid dehydrogenase and coenzyme I or coenzyme II for reaction;

[0027] S4, freeze-drying the reaction solution after the completion of the reaction for 48 hours an...

Embodiment 1

[0038] Tablet preparation steps are as follows:

[0039] Step 1: Prescription: 50 parts by weight of artificial bear bile powder, 250 parts by weight of beta-cyclodextrin, 600 parts by weight of sucrose, 70 parts by weight of dextrin, 3.6 parts by weight of stevia, 5 parts by weight of menthol, and 5 parts by weight of peppermint oil , 3 parts by weight of magnesium stearate, 7 parts by weight of talcum powder;

[0040] Step 2: Mix artificial bear bile powder and beta cyclodextrin evenly, dissolve in 40%-80% ethanol, heat to 50°C-100°C, and stir for 0.5-1.5 hours to dissolve;

[0041] Step 3: Spray drying, add sucrose powder, dextrin, and stevioside and mix evenly, use 40% to 80% ethanol as a wetting agent to sieve to make 10 to 20 mesh granules and dry at 50°C to 100°C until the water content of the granules is 4 %~6%;

[0042] Step 4: Mix menthol and peppermint oil to dissolve, evenly spray on the above granules, then mix evenly with talcum powder and magnesium stearate, a...

Embodiment 2

[0043] Embodiment 2: the granule preparation steps are as follows

[0044] Step 1: Prescription: 50-150 parts by weight of artificial bear bile powder, 50-600 parts by weight of cyclodextrin, 100-500 parts by weight of starch, 300-1000 parts by weight of dextrin, 1000-5000 parts by weight of sugar, licorice extract 50-100 parts by weight of powder, 0.5-2.5 parts by weight of stevioside, 5-10 parts by weight of menthol, 5-10 parts by weight of peppermint oil, 0.2-1.3 parts by weight of tartrazine, and 2-5 parts by weight of sodium copper chlorophyllin;

[0045] Step 2: Take artificial bear bile powder and cyclodextrin and dissolve them in water and an organic solvent respectively to make a solution, stir and clathrate at a temperature of 25 degrees Celsius to 80 degrees Celsius, recover the organic solvent, and then spray dry to obtain the clathrate;

[0046] Step 3: Mix the inclusion compound with starch, dextrin, sugar, licorice extract powder, stevioside and other auxiliary ...

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Abstract

The invention relates to the technical field of medicine production, in particular to a preparation method of an artificial bear gall powder preparation. The preparation method comprises the followingsteps of S1, preparing raw materials: poultry and livestock gall powder, beta cyclodextrin, cane sugar, dextrin, steviosin, menthol, peppermint oil, magnesium stearate, talcum powder, ethanol, starch, licorice root extractum powder, stevioside, PVA-4000, PVA-6000, glycerine, polyvinylpyrrolidone, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, polyethylene glycol, dibutyl phthalate, a coloring agent and silicon dioxide; S2, dissolving the poultry and livestock gall powder with a buffered solution, performing centrifugation under the condition of 11000g, performing repeated filtrationto obtain filter residues and filtrate, and performing freeze drying and preservation on the filter residues; and S3, loading the filtrate in a reactor loaded with 7[alpha]-hydroxysteroid dehydrogenase. According to the preparation method disclosed by the invention, the artificial bear gall powder is designed to be a raw material medicine, and the artificial bear gall powder preparation is developed, so that the problem that natural bear gall raw materials are valuable and scarce is solved, and besides, a new medicine preparation is provided for human.

Description

technical field [0001] The invention relates to the technical field of medicine production, in particular to a preparation method of artificial bear bile powder preparation. Background technique [0002] Bear bile, obtained from the dried gallbladder bile of black bears or brown bears, has the effects of clearing away heat, calming the liver, and improving eyesight. Its main component is tauroursodeoxycholic acid (TUDCA). Bear bile is one of the four famous and precious animal medicines. It has a history of more than 2,000 years of use, and a large number of prescriptions contain bear bile. my country's annual output of bear bile powder is about 30 tons, which still cannot meet the needs of human health. At present, the contradiction between supply and demand of high-end bear bile powder is increasingly prominent and the market demand for bear bile powder for low-end raw materials continues to increase, which makes the price of bear bile powder rise steadily, and the market...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K35/57A61P29/00A61P1/16A61P27/02
CPCA61K35/413A61K35/57A61P29/00A61P1/16A61P27/02
Inventor 张小利穆竟伟王国明
Owner SHANGHAI KAIBAO PHARMA
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