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Prpearation method of H2 receptor antagonist composite salt and its application

A technology of receptor antagonists and compound salts, which is applied in the field of preparation and application of H2 receptor antagonist compound salts, and can solve problems such as no research data

Inactive Publication Date: 2003-12-10
漆又毛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Except for a patent containing a brief report on the synthesis of famotidine bismuth citrate, there is no research information about this product

Method used

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Embodiment Construction

[0035] Preferred H of the present invention 2 Receptor antagonist hydroxycitrate compound salt---famotidine hydroxybismuth ammonium citrate compound salt (referred to as compound salt) and a simple mixture of famotidine and hydroxybismuth ammonium citrate (referred to as mixture) are two different substances. The relevant evidence is as follows:

[0036] 1. The infrared spectra obtained by the two are different. For example the infrared spectrum of a mixture at υ max 1590, 1430, 1130, 940cm -1 There is a strong absorption peak at the position, while the absorption peak of the compound salt is υ max 1550, 1400, 1300, 1150, 910cm -1 ;

[0037] 2. The ultraviolet absorption spectra of the two are different, the former is u.v.163nm, and the latter is 180nm;

[0038] 3. The solubility of the two is different. The water solubility of the compound salt at room temperature is 8%; while the water solubility of the mixture is less than 1%.

[0039] According to the present invent...

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PUM

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Abstract

The present invention relates to a preparation method of H2 receptor antagonist compound salt and its application. The optimized H2 receptor antagonist is famotidine, and the optimized metal ions forming compound salt are bismuth and ammonium. Said compound salt is applicable for curing gastrointestinal disorder, specially for curing gastroduodenal diseases. It also has the stronger protecting action for rat acute injury of gastric mucosa due to ethyl alcohol, and has the action of raising gastric juice acidity and reducing gastric acid secretion for gastric secretion due to pyloric ligation.

Description

technical field [0001] The present invention relates to a H 2 Preparation method and application of receptor antagonist compound salt. Specifically, it involves the H 2 Compound salt method formed by receptor antagonist and hydroxycitrate and use thereof. Background technique [0002] Digestive system diseases are common diseases and frequently-occurring diseases, especially gastric and duodenal ulcers have the highest incidence rate, accounting for 10-20% of the total population. Therefore, anti-ulcer drugs have been in the leading position in the world sales for many years. [0003] The classic drugs for the treatment of peptic ulcer include antacids, anticholinergics, and gastric mucosal protective agents. In recent years, anti-HP drugs and proton pump inhibitors have been developed. [0004] Since the 1960s parietal cell epithelial histamine H 2 The discovery of the receptor and the 1976 histamine H 2 The advent of receptor antagonists ha...

Claims

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Application Information

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IPC IPC(8): A61K31/34A61K31/425A61K31/433A61K31/555A61P1/04A61P1/14
Inventor 漆又毛揭清
Owner 漆又毛
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