Method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine

A technology of ranitidine hydrochloride and cimetidine, which can be used in measurement devices, instruments, scientific instruments, etc., can solve the problems of lack of quantitative methods and rapid product screening.

Inactive Publication Date: 2019-09-27
太原市食品药品检验所
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

There is no quantitative method for this standard, and products produced by other manufacturers cannot be quickly screened according to this standard
In recent years, the applicant found that ranitidine hydrochloride and cimetidine were illegally added...

Method used

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  • Method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine
  • Method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine
  • Method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine

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Embodiment Construction

[0048] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0049]This example provides a kind of Chinese patent medicine and health food that detects strengthening the stomach, improving gastrointestinal function (with auxiliary protective effect on gastric mucosal injury), and auxiliary protective function on gastric mucosal injury, or other foods that illegally claim such functions. Qualitative and quantitative detection methods for illegally added 5 chemical drugs including ranitidine hydrochloride, cimetidine, famotidine, nizatidine, and lafutidine. The principle of the method is as follows: the sample is extracted and diluted with methanol ultrasonically, separated by a C18 chromatographic column, and qualitatively and quantitatively analyzed by a liquid chromatography-mass spectrometer.

[0050] The specific method is as follows:

[0051] 1. Materials

[0052] 1.1. Instrument

[0053] Shimadz...

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Abstract

The invention discloses a method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine. The method comprises the following steps: (1) selecting chromatographic conditions; (2) selecting mass spectrometric conditions; (3) preparing a standard solution; (4), preparing samples; (5), detecting and calculating. Tests prove that the method is rapid and high in specificity; the method is suitable for detecting the illegally added ranitidine hydrochloride, famotidine, lafutidine, nizatidine, cimetidine and other chemical medicines in Chinese patent medicines and health-care foods which have the effects of invigorating the stomach, improving the gastrointestinal function (having an auxiliary protection effect on gastric mucosal injury) and having an auxiliary protection effect on gastric mucosal injury or in other foods illegally claimed to have said functions.

Description

technical field [0001] The invention relates to the field of food (including health food) and drug testing methods, specifically Chinese patent medicines and health food aimed at invigorating the stomach, improving gastrointestinal function (with auxiliary protective effect on gastric mucosal damage), and with auxiliary protective function on gastric mucosal damage , or other foods that illegally claim such functions are illegally added with five H 2 Qualitative and quantitative detection methods of receptor blockers. Background technique [0002] With the development of social economy and the quickening pace of life, gastric acid, stomach pain, gastric mucosal injury, gastric ulcer and other gastrointestinal diseases have become common diseases with a high incidence rate. Many people think that western medicine has a lot of side effects, and they are more willing to buy Chinese patent medicines and health food with mild side effects and less side effects, or some foods tha...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/88
CPCG01N30/06G01N30/88
Inventor 赵丽红李忠华
Owner 太原市食品药品检验所
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