42 results about "Ranitidine Hydrochloride" patented technology

The invention discloses a composition for treating chicken proventriculitis and a preparation method thereof, which aim to provide a composition for treating the infection of chicken proventriculitis by addressing both symptoms and root causes and a preparation method thereof. The composition comprises the following components in percentage by weight: 1 to 10 percent of florfenicol, 5 to 15 percent of metronidazole, 1 to 6 percent of ranitidine hydrochloride, 2 to 15 percent of taurine and the balance of glucosum anhydricum. In the composition, aiming at pathogeny, the florfenicol and the metronidazole which serve as antimicrobial medicaments are adopted to kill anaerobic bacteria and helicobacter pylori effectively, reduce the occurrence probability of the tolerance of pathogenic bacteria and improve the sensitivity; the ranitidine hydrochloride inhibits the gastric acid effect and reduces the injury of gastric acid to inflamed glandular stomachs; and the taurine has the obvious effect of inflammation resistance, has no irritation on gastrointestinal tracts, and has the effect of diminishing inflammation quickly. Aiming at the pathogeny and diseases, the medicaments are combined, so that the composition can address both symptoms and root causes effectively on antipathogen and clinical symptoms thereof and treat the chicken proventriculitis effectively.

The invention discloses a Ranitidine hydrochloride capsule producing technique, raw material being Ranitidine hydrochloride, assistant material being amylum, and lubricant being magnesium stearate. Mix raw and assistant materials to make particles, then dry to mix evenly, add in the lubricant, and finally capsulize to make the finished product. After mixing raw and assistant materials, add in 50-95% alcohol solution as wetter replacing bond, to make particles, so as to make the particles looser, extremely easy to dissolve in water and having fluidity.

A freeze-dried powder injection of ranitidine hydrochloride is proportionally prepared from ranitidine hydrochloride, freeze-drying supporting agent, stabilizer and pH regulator through proportionally dissolving the active component in the water for injection while stirring, regulating pH value until it becomes neutral, adding the carbon for injection, stirring, filtering for removing carbon, filtering with 0.45-micron micropore film and then with 0.22-micron micropore film, bottling, freeze-drying, and vacuum sealing.

The invention provides a method for synthesis of ranitidine alkali and ranitidine hydrochloride. It is characterized in that: 2- [ [ [5- (dimethylamino) methyl- 2- furyl] methyl] sulpho] ethylamine reacts with 1- methylthio - 1- methylamino- 2- nitro ethylene directly in water phase, crystallizing and separating out ranitidine alkali. The synthesis method comprises the following steps: adding 2- [ [ [5- (dimethylamino) methyl- 2- furyl] methyl] sulpho] ethylamine and 1- methylthio- 1- methylamino- 2- nitro ethylene with a molar ratio of 1.04: 1 into water, heating to 48- 52 Deg. C, reacting 4.5 hours with a vacuum degree of 0.02- 0.05 MPa, cooling, adding sodium-hydroxide of concentration of 10% to regulate the PH value to 11.0- 11.4, filtrating and cooling the filtrate to 0- 2 Deg. C, crystallizing for 12 hours, centrifugally filtrating, and rinsing filter cake with purity water to prepare wet ranitidine alkali; dissolving ranitidine alkali in alcohol and reacting with chlorhydric acid to prepare ranitidine hydrochloride.

The invention relates to the solid preparation of a ranitidine hydrochloride/bismuth potassium citrate medicinal composition, which is prepared by mixing ranitidine hydrochloride/bismuth potassium citrate medicinal composition microcapsules and other pharmaceutical adjuvant required by the preparation of the solid preparation, wherein the ranitidine hydrochloride/bismuth potassium citrate medicinal composition microcapsules are prepared from ranitidine hydrochloride, bismuth potassium citrate, chitosan and sodium alginate. Compared with the prior art, the preparation of the invention has the characteristics of greatly improved stability and bioavailability, and stable and persistent release.

The invention relates to the field of drug detection, in particular to a method for determining ranitidine hydrochloride related substances through high performance liquid chromatography. According tothe method disclosed by the invention, octadecylsilane chemically bonded silica is used as a filler, mobile phases comprise a mobile phase A and a mobile phase B, the mobile phase A and the mobile phase B are both a mixed solution of a modified phosphate buffer solution and acetonitrile, the pH value of the modified phosphate buffer solution is 6.70+/-0.05, the flow velocity of the mobile phasesis 1.1-1.3ml/min, and gradient elution is adopted. By using the method disclosed by the invention, ranitidine hydrochloride related substances can be separated in a high performance liquid chromatogram. By optimizing the conditions, the sensitivity and the accuracy of the detection of each component are further improved. The method enables the quality of ranitidine hydrochloride to be better controlled, has the advantages of high analysis speed, good specificity and high reproducibility, facilitates the quality detecting and monitoring of ranitidine hydrochloride, and is beneficial to safe application and popularization of ranitidine hydrochloride.

The invention discloses ranitidine hydrochloride capsules and a production method thereof. Every 1,000 capsules comprise 165 to 170 parts of ranitidine hydrochloride and 40 to 50 parts of calcium hydrophosphate. The preparation method for the capsules comprises the following steps: weighing the ranitidine hydrochloride and the calcium hydrophosphate according to the weight part; crushing the ranitidine hydrochloride and the calcium hydrophosphate respectively, adding 50 percent ethanol in a trough type mixing machine to mix for 20 to 40 minutes to prepare a soft material, and granulating; drying the prepared granules in a hot-air circulation drying oven at the temperature of lower than 70 DEG C, and controlling the moisture within 4 percent; and filling the dried granules in capsules, andpolishing to obtain the ranitidine hydrochloride capsules. The ranitidine hydrochloride capsules and the production method thereof have the advantages that: the calcium hydrophosphate is adopted as an auxiliary material, so that each quality index of the product in a valid period is ensured to be basically stable, the problem of hygroscopicity of the ranitidine hydrochloride capsules can be solved, the product stability is improved, and intake of talc powder and magnesium stearate is prevented.

The invention discloses a medicine ranitidine hydrochloride compound for treating stomach illness and a preparation method of the of medicine ranitidine hydrochloride compound, belonging to the technical field of medicines. The X-ray powder diffraction pattern of the compound, obtained through measurement with Cu-K alpha ray, is shown in the figure 1. The new crystal form of the compound provided by the invention is different form crystal form structures in the prior art. Experiments disclose a pleasant surprise that the compound having the new crystal from structure hardly absorbs moisture and has good stability and therefore the problems that ranitidine hydrochloride is not stable in damp, heat and air and ranitidine hydrochloride products can be oxidized easily, are liable to change color after absorbing moisture and poor in stability can be solved thoroughly. The preparations of the ranitidine hydrochloride compound disclosed by the invention can be prepared conveniently.

The invention discloses a method for detecting ranitidine hydrochloride, cimetidine, famotidine, nizatidine and lafutidine. The method comprises the following steps: (1) selecting chromatographic conditions; (2) selecting mass spectrometric conditions; (3) preparing a standard solution; (4), preparing samples; (5), detecting and calculating. Tests prove that the method is rapid and high in specificity; the method is suitable for detecting the illegally added ranitidine hydrochloride, famotidine, lafutidine, nizatidine, cimetidine and other chemical medicines in Chinese patent medicines and health-care foods which have the effects of invigorating the stomach, improving the gastrointestinal function (having an auxiliary protection effect on gastric mucosal injury) and having an auxiliary protection effect on gastric mucosal injury or in other foods illegally claimed to have said functions.

The invention relates to the technical field of separation and purification of fine chemicals, and more concretely relates to a method for refining ranitidine base. By using a mixed solvent prepared from an intensive polar solvent and a weak polar solvent, the dissolvability of ranitidine base and impurities in the solvent is different, so that the ranitidine base and the impurities can be effectively separated during a crystallization process, and an obtained refined product is high in purity and stable in property. After analyzing the ranitidine base refined through the method provided by the invention through a liquid chromatograph, the purity of the ranitidine base is not less than 99.0 percent, the total impurity is not larger than 0.15 percent, and the single impurity is not larger than 0.05 percent. A ranitidine hydrochloride product obtained through salifying the ranitidine base prepared and purified through the method provided by the invention has the purity reaching and beingsuperior to the quality level of an original drug, so that the safety of the drug during a use process is further improved.

The invention relates to a ranitidine hydrochloride powder injection for injection, specifically to a pharmaceutical composition. The ranitidine hydrochloride powder injection contains ranitidine, a freeze-drying excipient and an optional acidifying or alkalizing agent. The invention also relates to a preparation method of the pharmaceutical composition. The pharmaceutical composition, which is used as an excellent and potent histamine H2 receptor antagonist, can be used to effectively inhibit gastric acid secretion caused by stimulation of histamine, pentagastrin and carbechal, reduce gastric acid and gastric enzyme activity, and is an excellent gastropathy medicine for treating hyperacidity and heartburn. The powder injection provided by the invention has good pharmaceutical properties.

The invention relates to a method for extracting small molecule polypeptides for medicament preparation, which comprises carrying out alkali hydrolysis to the duck's egg membrane, removing residue after the completion of hydrolysis, diluting the solution for use as medicament directly, which has the function for treating stomach ulcer. The hydrolysate can also be neutralized for alkali expelling, so as to prepare concentrated liquid or dried product after concentration.

The invention discloses a preparation method of ranitidine hydrochloride, the chemical name of said ranitidine hydrochloride is N'-methyl-N-[2[[5-[(dimethylamino)methyl-2-furan Base] methyl] thio] ethyl]-2-nitro-1,1-ethylenediamine hydrochloride, the chemical structural formula of said ranitidine hydrochloride is, and the molecular formula of said ranitidine hydrochloride is C13H22N4O3S ·HCl: the invention has simple steps, higher yield than the existing level, high purity, reduced production cost, and is suitable for mass production.

The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method of ranitidine hydrochloride tablets. The method selects auxiliary materials which are suitable for direct tabletting and have moisture-proof function, such as microcrystalline cellulose, anhydrous calcium hydrogen phosphate, magnesium stearate and silicon dioxide, adopts adirect tabletting process at the same time, solves the problem of moisture absorption of the tablet core, avoids the drying process of particles after wet granulation, and improves product quality and production efficiency. The process is simple, easy to implement, and suitable for large-scale production.

The invention relates to the technical field of medicines, and discloses a formula and a preparation method for a ranitidine hydrochloride slow release suspension. The slow release suspension comprises the following ingredients in parts by weight: 20-80% of ranitidine hydrochloride medicine carrying resin micro-capsule, 20-80% of slow release auxiliary material and the balance of other auxiliary materials. Since a dynamic method is adopted to prepare the ranitidine hydrochloride medicine resin, the medicine carrying rate of the medicine resin can be obviously improved. Through reasonable configuration, the ranitidine hydrochloride is prepared into the oral liquid slow release suspension. According to different dosage requirements, the slow release suspension is taken according to dosages,and the slow release suspension has the advantages of large distribution area in gastrointestinal tracts, high adsorption speed, stable blood concentration and high bioavailability, and can reduce irritation to gastrointestinal tracts and the influence on in-vivo behaviors by a gastric emptying rate. Meanwhile, ranitidine and ion exchange resin generate ion exchange, so that a medicine enters a skeleton to cover the bitter taste of the ranitidine hydrochloride.

The invention relates to a pharmaceutical composition of paclitaxel and ranitidine hydrochloride, and especially relates to an application product of the pharmaceutical composition, wherein the application product comprises paclitaxel injection and an injection containing ranitidine hydrochloride. Administration comprises following steps, the injection containing ranitidine hydrochloride is applied firstly by intravenous injection, the paclitaxel injection is dissolved and diluted by normal saline or 5% glucose and sodium chloride solution, and then the diluted paclitaxel injection is applied by intravenous drop infusion.

The invention discloses a pharmaceutical composition for treating chronic gastroenteritis, which is prepared from the following raw materials: belladonna and aluminium dispersible tablets, levocarnitine, bismuth potassium citrate, metronidazole, ranitidine hydrochloride, vitamin B, lovastatin, niacin, calcium pantothenate, niacinamide, L-arginine, jujube polysaccharide, cassia seed, fructus crataegi, radix et rhizoma salviae miltiorrhizae, radix et rhizoma rhei, ginger, tartary buckwheat, radix puerariae lobatae, leucocyanidin, vitexin, astragalin, cryptoxanthin and quercetin. The pharmaceutical composition for treating chronic gastroenteritis has the synergistic effects through the compounding of the raw materials, has obvious anti-inflammatory activity, and has the advantages of both symptoms and roots treatment of the disease, obvious curative effects, convenient taking, no recurrence and no rebound after cure, little toxic and side effects, no complication, long-term use, less residues and low price, so that the production cost is reduced and the waste of resources is avoided.

The invention discloses a pharmaceutical composition for treating chronic gastroenteritis. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 5-10 parts of rabeprazole, 5-10 parts of levocarnitine, 0.1-1 part of vitamin H, 2-5 parts of rebaudioside A, 3-8 parts of aluminium phosphate, 0.1-0.5 part of allicin, 1-5 parts of chitosan, 2-5 parts of taurine, 5-10 parts of glutamine, 5-15 parts of an earthworm protein powder, 2-10 parts of dendrobine, 2-10 parts of artemisinin, 2-5 parts of acetylkitasamycin, 1-5 parts of ranitidine hydrochloride, 40-80 parts of ethyl alcohol and 50-100 parts of distilled water. The raw materials are compounded to achieve a synergistic effect, and the pharmaceutical composition for treating chronic gastroenteritis has remarkable anti-inflammatory activity, can treat both symptoms and root causes, is remarkable in effect and convenient to take, ensures no recurrence after curing, and is small in toxic and/or side effect and free from complications.

The invention discloses a medicine for treating stomach illness. The medicine is processed by mixing raw materials, and comprises, by weight, 140 mg-150 mg of metoclopramide tablets, 2200 mg-2500 mg of a furazolidone tablets, 2200 mg-2600 mg of cimetidine tablets, 1650 mg-2100 mg of ranitidine hydrochloride capsules, 16800 mg-18000 mg of yeast tablets and 3600 mg-4000 mg of Yunnan Baiyao powder. When the medicine is prepared, the above raw materials are mixed and polished into powder; and after the powder is qualified through microbiological detection, filling of the powder is carried out in a manner of a capsule. When the medicine is prepared, common Western medicine materials serve as the raw materials, the preparing process is simple, and the production cost is low; the product has the effects of supporting the healthy energy and stopping acid pains and is mainly used for treating the stomach illness such as gastral cavity pains, hyperacidity, congestion and edema which are caused by liver-stomach disharmony; and symptoms such as pains, giddiness, choking sensation in chest and bleeding which are caused by the stomach illness can be reduced.

The invention provides a compound preparation containing ranitidine hydrochloride and troxipide and application thereof. The matching of ranitidine hydrochloride and troxipide according to weight ratio ranges from 6:1 to 1:6. Compared with the prior art, the compound preparation has the following advantages and active effects: ranitidine hydrochloride and troxipide have a pharmacology function and a coordinate effect, not only can treat stomach and intestine diseases including heartburn, gastropathy acid return and the like caused by gastric mucosal damage and too much gastric acid during acute-outbreak periods of acute gastritis and chronic gastritis, but also reinforce defense factors, improve recovery of ulcer diseases and metabolism of blood circulation of gastric mucosa at the ulcer parts, and enable gastric mucosa tissue components to be normalized. The effective dosage of ranitidine hydrochloride and troxipide in the compound preparation can be ensured, and the compound preparation further has the advantages of being effective in oral taking, similar in peak time and rapid in absorption.

A compound medicine for treating pyrosis, gastritis, indigestion, gastrointestinal diseases, etc is proportionally prepared from ranitidine hydrochloride and sucralfate.