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Medicine ranitidine hydrochloride compound for treating stomach illness and preparation method of medicine ranitidine hydrochloride compound

A technology of ranitidine hydrochloride and compound, which is applied in the field of drug ranitidine hydrochloride for treating gastric diseases and its preparation field, can solve the problems of easy moisture absorption and discoloration, poor stability, difficult preparation of preparations, etc., and achieves low moisture absorption and stability. Good performance and easy preparation

Active Publication Date: 2015-08-05
启东市和洪农副产品专业合作社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because raw materials are easy to absorb moisture, resulting in discoloration, poor stability and other reasons, it seriously affects the quality of the preparation product and brings difficulties to the preparation of the preparation.
[0006] Therefore, be necessary to develop a kind of ranitidine hydrochloride new compound, fundamentally solve ranitidine hydrochloride meeting wet, heat, unstable air, the product is easily oxidized, easy to absorb moisture and discoloration, problems such as poor stability, for preparation The preparation provides convenience

Method used

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  • Medicine ranitidine hydrochloride compound for treating stomach illness and preparation method of medicine ranitidine hydrochloride compound
  • Medicine ranitidine hydrochloride compound for treating stomach illness and preparation method of medicine ranitidine hydrochloride compound
  • Medicine ranitidine hydrochloride compound for treating stomach illness and preparation method of medicine ranitidine hydrochloride compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: The preparation method of ranitidine hydrochloride compound, the steps are as follows:

[0025] Dissolve the solid ranitidine hydrochloride in a methanol solution with a volume of 8 times the weight of ranitidine hydrochloride at 20°C; first add a mixed solvent of ethanol and acetone with a total volume of 10 times the weight of ranitidine hydrochloride. The volume ratio to acetone is 1.5:1. Stir while adding, control the temperature at 20°C, and cultivate the crystal for 0.5 hours; then add acetone and 2,4-dimethyl in a total volume of 12 times the weight of ranitidine hydrochloride The mixed solvent of base pyridine, the volume ratio of acetone to 2,4-lutidine is 3:2. After the crystal is grown for 1 hour, the temperature is reduced to -5°C at a rate of 10°C / hour, and then the stirring speed is maintained at 120 rpm. Stirring for crystallization and crystallization for 2 hours; filtration, 40° C. and drying under reduced pressure to obtain ranitidine hydrochl...

Embodiment 2

[0027] Example 2: The preparation method of ranitidine hydrochloride compound, the steps are as follows:

[0028] Dissolve the solid ranitidine hydrochloride in a methanol solution with a volume of 9 times the weight of ranitidine hydrochloride at 22.5°C; first add a mixed solvent of ethanol and acetone with a total volume of 11 times the weight of ranitidine hydrochloride. The volume ratio to acetone is 1.5:1. Stir while adding, control the temperature at 22.5°C, and grow the crystal for 0.75 hours; then add acetone and 2,4-dimethyl in a total volume of 18.5 times the weight of ranitidine hydrochloride The mixed solvent of base pyridine, the volume ratio of acetone to 2,4-lutidine is 3:2. After culturing the crystal for 1.5 hours, the temperature is lowered to -5°C at a rate of 12.5°C / hour, and then the stirring speed is maintained at 135 rpm. Stirring for crystallization and crystallization for 2.5 hours; filtering, 45°C, and drying under reduced pressure to obtain ranitidine ...

Embodiment 3

[0030] Example 3: The preparation method of ranitidine hydrochloride compound, the steps are as follows:

[0031] Dissolve the solid ranitidine hydrochloride in a methanol solution with a volume of 10 times the weight of ranitidine hydrochloride at 25°C; first add a mixed solvent of ethanol and acetone with a total volume of 12 times the weight of ranitidine hydrochloride, ethanol The volume ratio to acetone is 1.5:1. Stir while adding, control the temperature at 25°C, and cultivate the crystal for 1 hour; then add acetone and 2,4-dimethyl in a total volume of 25 times the weight of ranitidine hydrochloride The mixed solvent of base pyridine, the volume ratio of acetone to 2,4-lutidine is 3:2. After culturing the crystals for 2 hours, the temperature is reduced to -5°C at a rate of 15°C / hour, and then the stirring speed is maintained at 150 rpm. Stirring for crystallization and crystallization for 3 hours; filtering, drying at 50°C under reduced pressure to obtain ranitidine hyd...

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Abstract

The invention discloses a medicine ranitidine hydrochloride compound for treating stomach illness and a preparation method of the of medicine ranitidine hydrochloride compound, belonging to the technical field of medicines. The X-ray powder diffraction pattern of the compound, obtained through measurement with Cu-K alpha ray, is shown in the figure 1. The new crystal form of the compound provided by the invention is different form crystal form structures in the prior art. Experiments disclose a pleasant surprise that the compound having the new crystal from structure hardly absorbs moisture and has good stability and therefore the problems that ranitidine hydrochloride is not stable in damp, heat and air and ranitidine hydrochloride products can be oxidized easily, are liable to change color after absorbing moisture and poor in stability can be solved thoroughly. The preparations of the ranitidine hydrochloride compound disclosed by the invention can be prepared conveniently.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a drug ranitidine hydrochloride compound for treating stomach diseases and a preparation method thereof. Background technique [0002] Ranitidine, like cimetidine, is currently the most widely used drug for the treatment of ulcer disease. Developed by the British company Glaxo. It was synthesized by British Price in 1976, and its pharmacology was clarified by Bradshaw in 1979. In 1980, Berstad reported that it was effective for duodenal ulcer. Apps in hundreds of countries. my country was produced by Shanghai Sixth Pharmaceutical Factory in 1985. [0003] Ranitidine is a selective H2 receptor antagonist, which can effectively inhibit the gastric acid secretion caused by histamine, pentagastrin and food stimulation, reduce the activity of gastric acid and gastric enzymes, but has no effect on gastrin and The secretion of sex hormones was not affected. The effect is 5-8 times s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/52
CPCC07B2200/13C07D307/52
Inventor 刘学键
Owner 启东市和洪农副产品专业合作社
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