Supercharge Your Innovation With Domain-Expert AI Agents!

Ranitidine hydrochloride lipidosome capsule and new application thereof

A technology of ranitidine hydrochloride fat and ranitidine hydrochloride, which is applied in the field of medicine, can solve the problems of high production cost of freeze-dried powder injection, high environmental requirements, and poor quality of finished products, so as to improve the drug therapeutic index and production process Simple, low-cost effect

Inactive Publication Date: 2011-02-02
HAINAN MEIDA PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two patents provide ranitidine hydrochloride freeze-dried powder injection and its preparation method, but due to the instability of ranitidine hydrochloride in aqueous solution, discoloration will also occur during the preparation of liquid medicine and freeze-drying process, resulting in The quality of the finished product is poor, and the production cost of freeze-dried powder injection is high, and the environmental requirements are also high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ranitidine hydrochloride lipidosome capsule and new application thereof
  • Ranitidine hydrochloride lipidosome capsule and new application thereof
  • Ranitidine hydrochloride lipidosome capsule and new application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of ranitidine hydrochloride liposome

[0037] Prescription: Ranitidine Hydrochloride 150g

[0038] Egg Yolk Lecithin 750g

[0039] Cholesterol 75g

[0040]Sodium Glycocholate 150g

[0041] Tween 80 150g

[0042] Preparation Process

[0043] (1) Dissolve 750g egg yolk lecithin, 75g cholesterol, and 150g sodium glycocholate in 3000ml ethanol, mix well, and remove ethanol under reduced pressure on a rotary thin film evaporator to obtain a phospholipid film;

[0044] (2) Add 1500ml of acetic acid-sodium acetate buffer solution with pH=4.0, stir to completely hydrate the phospholipid membrane, and then homogenize and emulsify at a high speed for 20min with a tissue masher at a speed of 12000r / min to prepare a blank liposome suspension;

[0045] (3) 150g of ranitidine hydrochloride and 150g of Tween 80 were dissolved in 3000ml of water, added to the blank liposome suspension, kept at 65°C, and homogeneously emulsified for 10min ...

Embodiment 2

[0054] Example 2 Preparation of ranitidine hydrochloride liposome

[0055] Prescription: Ranitidine Hydrochloride 75g

[0056] Yolk Lecithin 675g

[0057] Cholesterol 375g

[0058] Sodium Glycocholate 450g

[0059] Tween 80 300g

[0060] Preparation Process

[0061] (1) 675g egg yolk lecithin, 375g cholesterol, and 450g sodium glycocholate were dissolved in 7500ml ethanol, mixed uniformly, and ethanol was removed under reduced pressure on a rotary thin film evaporator to obtain a phospholipid film;

[0062] (2) Add pH = 5.0 sodium dihydrogen phosphate-disodium hydrogen phosphate buffer solution 2500ml, stir to completely hydrate the phospholipid membrane, then homogenize and emulsify for 10 minutes with a tissue masher at a speed of 15000r / min to prepare a blank lipid body suspension;

[0063] (3) 75g of ranitidine hydrochloride and 300g of Tween 80 were dissolved in 4000ml of water, added to the blank liposome suspension, kept at 55°C, and homogeneously emulsified f...

Embodiment 3

[0074] Example 3 Preparation of Ranitidine Hydrochloride Capsules

[0075] Ranitidine hydrochloride liposome (calculated as ranitidine) 75g

[0076] Microcrystalline Cellulose 75g

[0077] Lactose 50g

[0078] Povidone K30 5g

[0079] Talc powder 5g

[0080] Preparation Process

[0081] (1) pulverize the liposome containing 75g ranitidine hydrochloride, cross 80 mesh sieves, and set aside;

[0082] (2) Take by weighing 75g microcrystalline cellulose, 50g lactose, cross 80 mesh sieves, mix, set aside;

[0083] (3) Mix the above raw and auxiliary materials evenly, add 5% povidone K 30 100ml of 80% ethanol solution is used to make soft materials, pass through a 20-mesh sieve to granulate, dry at 60°C, and granulate through a 18-mesh sieve to obtain ranitidine hydrochloride granules;

[0084] (4) Fill the dried granules into capsules to prepare ranitidine hydrochloride capsules.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a ranitidine hydrochloride lipidosome capsule and new application thereof. Particularly, certain amounts of yolk lecithin, cholesterin, natrium glycocholicum, tween 80 and an active ingredient ranitidine hydrochloride are combined and are prepared into ranitidine hydrochloride lipidosome by film dispersion technology, and the ranitidine hydrochloride lipidosome is mixed with the general accessories of medicine to prepare the capsule. The ranitidine hydrochloride lipidosome capsule better solves the problems of easy deliquescence, moisture absorption, color change and poor stability of the ranitidine hydrochloride, increases preparation medical effect and biological availability and can be used for treating herpetic stomatitis of childrem.

Description

technical field [0001] The invention relates to a liposome capsule preparation, in particular to a ranitidine hydrochloride liposome capsule for treating herpetic stomatitis in children and its new application, belonging to the technical field of medicine. Background technique [0002] Herpetic stomatitis is a common disease in children caused by herpes simplex virus. It is contagious and recurrent, and has no obvious seasonality. The average incubation period is 6 days. The main manifestations are fever, salivation, and oral ulcers. Refusal to eat because of oral ulcer pain made the family extremely anxious. [0003] Ranitidine is an H2 receptor antagonist, which is effective in the treatment of herpes simplex. It may compete with this product to inhibit histamine H2 receptors, enhance the body's immune function, inhibit microvascular permeability, reduce body fluid exudation, and protect normal skin and mucous membranes. Thereby inhibiting the secretion and exudation of h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K9/48A61K31/34A61K47/34A61K47/28A61K47/24A61P1/02A61P31/22A61K47/10A61K47/26
Inventor 邱民
Owner HAINAN MEIDA PHARMA
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com